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Sleep Paralysis - Cultural Significance and Its Management
Javed Ather Siddiqui, Shazia Farheen Qureshi, Abdul Khaliq Alghamdi, Waseem M Marei
92Psychosomatic Medicine Research    2019, 1 (2): 19-25.   https://doi.org/10.12032/psmr2019-0920-007
Abstract ( 778 PDF (259KB) ( 1056 )  
Sleep paralysis (SP) is a benign, transient episode of immobility and it lasts a few seconds to a few minutes. It can occur while falling asleep or on awakening. It is a condition of unknown etiology and all the skeletal muscles are almost ‘paralyzed’. It leads to an inability to speak or move but individual remains conscious. This review summarizes the existential clinical literature on sleep paralysis most relevant to practitioners; also summarizes the many historical and artistic manifestations of SP in different cultures. It also throws light on the available Arabic literature and others as per the aim of the review. For this review, literature search using engines was carried out, and review papers and original research articles were analyzed. We will start with a review which summarizes the collection of symptoms, prevalence rate, risk factors and etiological theories, characteristics and classification of the SP over the past years up to the present time, also the management in the form of psychotherapy and pharmacotherapy as well as the cultural significances in different countries. SP plays an important role in the genesis and maintenance of many supernatural beliefs such as nocturnal alien abductions, demonic and ghost attacks in individuals with intact reality testing.
Research Progress of Sodium Channel and Its Anti-arrhythmic Drugs
Bo Liang, Hui-Ling Liao
Psychosomatic Medicine Research    2019, 1 (1): 5-9.   https://doi.org/10.12032/psmr2019-0610-002
Abstract ( 174 PDF (239KB) ( 54 )  
With the acceleration of population aging,heart disease has been a high priority,and cardiac ion channel research has been one of the hot spots in the field.Sodium ion channels,as the most important class,have been widely concerned. Therefore,this paper briefly introduces and discusses three aspects of the structure and function of sodium ion channels and the development of drug research.
Psychosomatic Medicine Research: a Bridge Between Physical and Psychological Therapy
Editorial Board of PSMR
Psychosomatic Medicine Research    2019, 1 (1): 1-1.   https://doi.org/10.12032/psmr2019-0610-005
Abstract ( 169 PDF (128KB) ( 31 )  
Psychosomatic Medicine Research is an English life science academic journal featuring the scientific
foundation and clinical treatment of psychosomatic medicine. The journal is widely published in a
variety of cutting-edge research areas such as psychotherapy, clinical medicine, psychology,
artificial intelligence, tissue engineering, human chemistry, and artistic aesthetics. The purpose is to
study the relationship between psychological factors and physiological conditions in the occurrence of
human diseases, strengthen academic exchanges among researchers in different disciplines, and
jointly explore scientific phenomena closely related to human psychosomatic diseases.
A Review on the Citations of Daivavyapashraa Chikitsain Ayurveda
Divya Jyothi
Psychosomatic Medicine Research    2019, 1 (1): 10-12.   https://doi.org/10.12032/psmr2019-0610-003
Abstract ( 161 PDF (214KB) ( 50 )  
In Ayurveda, one can get an assortment of references regarding Yuktivyapashraya Chikitsa (a treatment modality which is based on logic). Ayurveda always has given importance for the treatment by using multiple drugs which are of plant origin or mineral origin. Daivavyapashraya Chikitsa (a modality of treatment based on past deeds and pleasing of God) though mentioned as the first line of therapy nowhere in the famous Ayurvedic classics have explained it in detail.  For this type of Chikitsa, the causes and the manifestation of the disease are to be analysed by taking the help of other sciences such as astrology. To conduct rituals, one has to be proficient in knowing and chanting hymns. It might be thereason for the less availability of description about Daivavyapashraya Chikitsa in the available Ayurvedic classics. Surprisingly an unpublished manuscript named Kashyapa Samhita deals with it enormously. It is exciting to know that the author of this manuscript has tried to analyse every disease uniquely. This paper deals with the references of Daivavyapasharaya Chikitsa in the available Ayurvedic classics as well as from an unpublished manuscript Kashyapa Samhita.
TCM Treatment of Tumors
Hao-Ran Zhang
92Psychosomatic Medicine Research    2019, 1 (1): 13-18.   https://doi.org/10.12032/psmr2019-0610-004
Abstract ( 155 PDF (224KB) ( 37 )  
Tumors can also be considered as a physical and mental disease, and psychological factors can affect the probability of occurrence and prognosis of the tumor.Traditional Chinese medicine believes that the main cause of tumor-related depression is liver qi stagnation, and pathological factors such as turbidity and blood stasis affect each other.Helping patients to relieve mental pain and eliminate psychological barriers can speed up the symptoms and delay the progression of the disease, which is of great significance for the rehabilitation of cancer patients.Emotional theory is one of the traditional Chinese medicine characteristics theory, and it has been applied to clinics by doctors of the past.The occurrence and development of malignant tumors are closely related to emotions. Psychotherapy should go through the whole process of clinical treatment of malignant tumors.Traditional Chinese medicine has acupuncture therapy, acupoint sticking therapy, and five-tone therapy to improve the psychological state of patients.However, the psychological treatment of cancer patients in tumor clinical practice is often neglected. The use of traditional Chinese medicine to treat tumor-related depression can effectively improve patient mood and improve quality of life, which is worthy of clinical application.
History and Modern Application of Chinese Physical and Breathing Exercises
Teng Huang, Bin Hao
Psychosomatic Medicine Research    2019, 1 (1): 2-4.   https://doi.org/10.12032/psmr2019-0610-001
Abstract ( 150 PDF (197KB) ( 43 )  
Traditional Chinese medicine is the key to opening the treasure house of Chinese civilization. Traditional Chinese medicine treatment includes drugs, acupuncture, massage, cupping and other means. Chinese physical and breathing exercises is one of the most effective methods of exercise among various treatments. Chinese physical and breathing exercises can soften muscles and strengthen bones.. It has the functions of Qi and activating blood circulation and regulating the internal organs and internal organs. It can enhance physical fitness, prevent disease and cure diseases, and achieve the purpose of prolonging life. In order to provide guidance for the prevention and treatment of clinical diseases, this paper combines the literature records, theoretical basis, clinical application and related literature reports of Chinese physical and breathing exercises.
Study on Learning and Memory Ability of Mice Induced by Different Doses of D-galactose
Lei Yu, Xue Bai, Xiao-Li He
92Psychosomatic Medicine Research    2019, 1 (2): 44-51.   https://doi.org/10.12032/psmr2019-0920-009
Abstract ( 123 PDF (1057KB) ( 31 )  
Aim: To explore the influence of different doses of D-galactose on learning memory capacity in mice. Methods: The 2-month-old KM mice were randomly divided into D-galactose-treated groups (75, 100, 150, 300 mg·kg-1) and normal control group, with 12 mice in each group. The corresponding dose of D-galactose was administered subcutaneously to the back of the neck, and normal control group was injected subcutaneously with saline for 8 weeks. Learning memory capacity of mice was detected through Morris water maze, step-down passive avoidance test and new object recognition test. Meanwhile, the enzymatic indicators in the brain were determined to detect the damage degree in mice with different doses of D-galactose. Results: Compared with the normal control group, the spatial and non-spatial cognitive functions and brain enzyme levels of D-galactose in each dose group was damaged to varying degrees, especially the dose of 100 mg·kg-1 group. In the water maze experiment, D-galactose groups significantly prolonged the time of crossing the platform for the first time and decreased the number of crossing platforms, especially at the dose of 100 mg·kg-1 (P < 0.05); in the new object recognition experiment, discrimination index was significantly decreased in each D-galactose group (P < 0.01), and the dose of 100 mg·kg-1 was most obvious; in addition, D-galactose could significantly increase the level of acetylcholinesterase (AChE) (P < 0.01), decrease the levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC) (P < 0.05 or P < 0.01) in the mice brain. Conclusion: Subcutaneous injection of low-medium-high dose of D-galactose for 8 weeks in the back of the neck can cause changes in brain parameters in mice, but the effects of different doses of D-galactose on some indicators are significantly different. D-galactose model is effective and stable at the dose of 100 mg·kg-1.
Experimental Research Progress of Treating Irritable Bowel Syndrome by Chinese medicine
Yue-Yang Liu
92Psychosomatic Medicine Research    2019, 1 (2): 32-38.   https://doi.org/10.12032/psmr2019-0920-006
Abstract ( 102 PDF (276KB) ( 30 )  
Irritable bowel syndrome (IBS) is a frequent-occurring clinical disease that belongs to one of the intestinal functional diseases. The etiology of IBS remains unclear. At present, it is considered to be related to mental, neurological factors and intestinal stimulation. Clinical practice proved that traditional Chinese medicine (TCM) treatment of IBS had the advantages with small adverse reactions, so that raised more and more attentions recently. This paper reviewed the recent progresses of experimental research on IBS from aspects of ancient classical prescriptions, contemporary experience prescription and acupuncture respectively. The purpose of this paper is to provide comprehensive reference for clinical IBS treatment, and facilitate revealing the mechanism of TCM treatment of IBS systematically.
Research Progress on the Relationship Between White Matter Lesions and Vascular Cognitive Impairment
Wen-Jing Zhou, Yao-Ming Xu
92Psychosomatic Medicine Research    2019, 1 (2): 26-31.   https://doi.org/10.12032/psmr2019-0920-008
Abstract ( 100 PDF (239KB) ( 34 )  
As the incidence of cerebrovascular disease increases, the incidence of white matter lesions (WMLs) and vascular cognitive impairment (VCI) also increases. Ischemic WMLs is directly related to VCI, especially non-dementia VCI. Early symptoms of non-dementia VCI are hidden and difficult to identify. About 50% of patients develop dementia. This article reviews the correlation between WMLs and VCI in terms of etiology, risk factors, pathogenesis and imaging manifestations. It provides scientific basis or ideas for clinical diagnosis and treatment for WMLs and VCI.
Research Progress in "Person-centered" Nursing
Yuan Jia, Meng-Ya Jing, Si-Yuan Yang, Li-Min Guo, Fan-Jie Meng, Xiang-Jie Wang
92Psychosomatic Medicine Research    2019, 1 (2): 39-43.   https://doi.org/10.12032/psmr2019-0920-010
Abstract ( 84 PDF (209KB) ( 16 )  
This paper reviews the research progress of “person-centered” nursing, and provides reference for the development of “person-centered” nursing in China. Currently, foreign scales have been developed to measure “person-centered” nursing, such as Individualized Care Scale, P-CA, Assess Health Care Providers’ Implementation of Patient-Cen, Person-centered Critical Care Nursing and Human-based Perioperative Care Scale. The “Person-centered” nursing model has been widely used in clinical nursing and nursing management. Studies have shown that “person-centered” nursing can improve patient' satisfaction and promote the physical and mental health of patients. At the same time, the combination of “person-centered” nursing and teaching promotes the innovation of medical education medicine, and its combination with architecture promotes the progress of hospital construction. Future research should focus on the overall layout of hospitals and wards, use more holistic means of psychosomatic medicine to set up more comprehensive humanistic concepts such as accompanying family members area, improve the breadth and depth of humanistic nursing field, and promote the development of humanistic nursing in China.
Efficacy of TCM Therapy of Claustrophobia: A Case Report
Bing-Sheng Yuan
92Psychosomatic Medicine Research    2019, 1 (3): 82-86.   https://doi.org/10.12032/psmr2019-1220-015
Abstract ( 35 PDF (461KB) ( 24 )  
Mrs. S, 55 years old, suffered from claustrophobia for more than 30 years, aggravated for 3 years, with anxiety, headache and tremor. Many kinds of treatments were ineffective. July 2, 2019, first visiting my clinic, according to traditional Chinese medicine (TCM), she was diagnosed as claustrophobia phobia/ psychosis (panic), which was caused by panic injury of kidney and brain. Treatment principle is to tonify Spleen and Kidney, to supplement Qi and blood, to adjust Du meridian, Chong meridian, and Ren meridian; to assist in resolving phlegm and tranquilizing heart. After five acupuncture sessions and TCM herbs, Mrs. S take the elevator (closed and windowless) three times this week, without any discomfort. No panic palpitations have occurred in recent weeks.
The Future of Rodent Models in the Research of Depression
Peng Chen, Jiexin Lei
92Psychosomatic Medicine Research    2019, 1 (3): 52-56.   https://doi.org/10.12032/psmr2019-1220-011
Abstract ( 34 PDF (665KB) ( 27 )  
Currently, over 300 million people worldwide live with depression, and the financial burden of this mental disease on the public systems is expected to increase significantly in the coming decades in the context of economic globalization. Despite the urgency of the crisis, we are still looking forward to develop improved therapeutics for this disorder, which has resulted in increasing criticism of the value and role of depression models in drug screening and preclinical studies. Recently, a variety of new approaches for studying depression-like behaviors in experimental animals has been developed. In this commentary, we discussed how various strategies such as genetic manipulation and circuit dissection to study the biological mechanisms underlying and/or mediating depression in humans. Finally, we also describe a brief framework for future research that can enhance our understanding about the neurobiological underpinnings of the disease and to address the urgent need to develop alternative therapeutic approaches to treat patients suffering from depression.
Potential Mechanism of Suanzaoren Decoction for Insomnia Based on Network Pharmacology
Bo Liang, Yu-Xiu Zhao, Hui-Ling Liao, Ning Gu
92Psychosomatic Medicine Research    2019, 1 (3): 62-72.   https://doi.org/10.12032/psmr2019-1220-013
Abstract ( 28 PDF (1889KB) ( 31 )  
Objective: To study the mechanism of Suanzaoren Decoction in the treatment of insomnia by using network pharmacology.
Methods: Chemical components and targets related to the Suanzaoren Decoction were searched through the traditional Chinese medicine systems pharmacology database and analysis platform, Traditional Chinese Medicines Database @ Taiwan and Traditional Chinese Medicines Integrated Database to construct the interaction network diagram of the target point of the compounds. The insomnia related targets were screened through GeneCards, MalaCards, NCBI-Gene, OMIM and CTD databases. The interactive target of Suanzaoren Decoction and insomnia was constructed in PPI database; GO analysis of screened core targets between drug target and disease target was carried out using DAVID database, and the related pathways of core targets were enriched using KEGG database.
Results: Using the oral bioavailability ≥ 30%, drug likeness ≥ 0.18, Caco-2 ≥ 0 and 4 ≤ half-life ≤ 8 as screening condition for the compounds, 35 effective components and 121 corresponding protein targets of Suanzaoren Decoction were screened out. A total of 336 enrichment results were obtained, including 301 biological processes, 25 molecular functions, and 10 cell compositions, on the condition of false discovery rate ≤ 0.0001. The selected targets were enriched by KEGG database and 17 pathways playing an important role in insomnia were screen out.
Conclusion: The synergetic effect of Suanzaoren Decoction with multi-components and multi-pathway was confirmed by network pharmacology, and the main possible mechanism of Suanzaoren Decoction in treating insomnia was predicted, which lay a foundation for the identification of effective components, the mechanism of action, and clinical application.
A Review of Management Research on Medical Risk in China
Jing Han, Hong-Xia Li , Tao Wang, Ming-Yu Zhang, Yu-Hua Ma, Xin-Yi Li, Yi-Bo Wu
92Psychosomatic Medicine Research    2019, 1 (3): 57-61.   https://doi.org/10.12032/psmr2019-1220-012
Abstract ( 26 PDF (260KB) ( 10 )  
With the development of medical industry and the improvement of people's legal consciousness, the issue of medical risk has been one of the social focusing problems in our country. We explore the current situation of medical risk in China, understand the research findings of medical risk management, and analyze the problems existing in the practice of medical risk management in China through electronic database, internet related websites and related works. Finally, we find that the situation of medical risk in China is severe, the research of medical risk management starts late, and the response system is not perfect. Medical managers should constantly learn and practice, strive to improve the risk management ability, and then improve the hospital's medical risk response ability, so as to promote the sustainable development of the hospital.
The Effect of Humanized Nursing on Blood Glucose Level of Diabetic Patients: A Meta-Analysis
Meng-Meng Wang, Xiu-Qing Wang
92Psychosomatic Medicine Research    2019, 1 (3): 73-81.   https://doi.org/10.12032/psmr2019-1220-014
Abstract ( 26 PDF (1266KB) ( 20 )  
Objective: Systematic evaluation of the effect of humanized nursing on the control of blood glucose level in Chinese diabetic patients.
Methods: The computer searches the full-text databases of CNKI, Wanfang, PubMed and EMBASE, and looks for the published randomized controlled trials on the effect of human-oriented nursing on the control of blood glucose level in diabetic patients. The retrieval time is from the establishment of the database to May 2019. Based on the inclusion and exclusion criteria, two researchers independently selected literature, extracted data and evaluated the risk of bias in the study, then used Revman 5.3 software for meta analysis, and Stata software for publication bias and sensitivity analysis.
Results: A total of 11 non randomized and non synchronous control studies were included, including 933 patients, 470 in the intervention group and 463 in the control group. The results of meta-analysis showed that the control level of humanized nursing on fasting blood glucose (MD = – 1.53, 95% CI – 2.12 ~ – 0.94) and the control level of humanized nursing on blood glucose 2 hours after meal (MD = -2.53, 95% CI-3.24 ~ -1.82) and the control level of humanized nursing on glycosylated hemoglobin (MD = -1.55, 95%CI -2.21 ~ -0.89) were relatively low, the difference was statistically significant.
Conclusions: The existing evidence shows that humanistic nursing can reduce the fasting blood glucose value, 2 hours postprandial blood glucose value and glycosylated hemoglobin value of diabetic patients, improve the prognosis of diabetic patients, and reduce the occurrence of complications. However, limited by the quantity and quality of the included studies, the effect of humanized nursing on blood glucose level control of diabetic patients still needs to be verified by high-quality and large sample studies.