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吴门验方 “ 阳和散结汤 ” 治疗乳腺癌理论浅析
成艳丽 彭涛 张国华
经典中医研究    2018, 1 (1): 9-12.   https://doi.org/10.12032/CCMR20180103
Abstract ( 3059 PDF (861KB) ( 745 )  
乳腺癌是女性最高发的恶性肿瘤,其发病率逐年上升,严重危害女性身心健康。吴雄志教授从事中医临床工作近 20 年,对肿瘤疾病有深刻的认识,所拟吴门验方 阳和散结汤 注重乳腺癌的病因与病位,采用中西汇通的思想,提高了对乳腺癌的治疗效果。
泽漆汤在肺癌治疗中的加减应用
彭涛
经典中医研究    2018, 1 (1): 5-8.   https://doi.org/10.12032/CCMR20180102
Abstract ( 2785 PDF (668KB) ( 672 )  
《金匮要略》泽漆汤治疗肺癌有一定临床疗效。笔者学习吴雄志教授使用泽漆汤治疗肺癌的理论和医案,结合自己临床使用的经验,从方药解析、合方加减、专病专药三方面展开论述,简要阐明泽漆汤在肺癌治疗中的方义和加减变化。
Camel milk could be helpful in the treatment of asthma
Mohammad Ravaghi, Mahdi Yousefi, Seyed Mousalreza Hosseini, Saeed Zibaee, Zohreh Feyzabadi, Roshanak Salari
Traditional Medicine Research    2018, 3 (6): 307-312.   https://doi.org/10.12032/TMR201814090
Abstract ( 1406 HTML PDF (443KB) ( 337 )  

Highlights

This paper proposed a hypothesis that camel milk could be helpful in the treatment of asthma.

Editor’s Summary

Food is a double-edged sword of health. On the one hand, cow milk could lead to the occurence of asthma. On the other hand, camel milk could be used to treat asthma via its effects of immunoregulation, antiinflammation and antioxygenation.

Abstract

Asthma is a chronic inflammatory disease with excessive irritability and airway narrowing and inflammation plays an important role in it. There are 300 million asthmatic people in the world currently. Main treatments for asthma include two groups of bronchodilators and inflammation controllers. Researches was continued in order to reach new treatments to reduce drug side effects and treatment-resistant cases or the types associated with weak treatment response. Today, World Health Organization recommends the application of traditional medicine especially in underdeveloped countries because of insufficient health resources and spread of diseases. Iranian traditional medicine (ITM) or Persian medicine is one of the oldest comprehensive traditional medicines with thousands years history which could help us to manage different diseases. The aim of this hypothesis is to investigate the camel milk as a complementary treatment of asthma because this chronic disease is sometimes resistant or response weakly to the treatment. In this article, the administration of camel milk in lung inflammatory diseases was studied by searching the PubMed and Scopus scientific databases. The results of this study indicated that camel milk due to having anti-inflammatory, immunomodulatory and anti-oxidant effects could decrease the levels of inflammatory factors such as tumor necrosis factor α, interleukin-17 (IL-17), IL-6, IL-1B and transforming growth factor-β1 in a human and animal samples with inflammatory diseases. Besides, based on ITM, camel milk was used in treatment patients with asthma. But, clinical studies are needed to validate the effectiveness of camel milk in asthma and its mechanisms.

柴苓汤治疗 2 例儿童支原体肺炎的观察
李玉林
经典中医研究    2019, 2 (1): 14-17.   https://doi.org/10.12032/CCMR20190104
Abstract ( 1304 PDF (1206KB) ( 628 )  
目的 : 使用小柴胡汤合上五苓散(柴苓汤)治疗支原体肺炎。方法 : 小柴胡汤和解少阳枢机,五苓散通调三焦水道,从水液输布代谢链治疗支原体肺炎。结果 :2 例支原体肺炎患儿使用柴苓汤后,体温恢复正常,肌体不适感消除。结论 : 柴苓汤治疗支原体引发的儿童高热、咳嗽、肺炎疗效确切,合方有效
A network pharmacology approach to investigate the mechanisms of Si-Jun-Zi decoction in the treatment of gastric precancerous lesions
Liang-Jun Yang, Dao-Rui Hou, Ya Li, Zhi-Peng Hu, Yong Zhang
Traditional Medicine Research    2018, 3 (6): 273-285.   https://doi.org/10.12032/TMR201814087
Abstract ( 1266 HTML PDF (1672KB) ( 691 )  

Highlights

The Si-Jun-Zi decoction may exert a therapeutic effect on gastric precancerous lesions by intervening in the mucosal inflammation, cell apoptosis process, and cell proliferation.

Editor’s Summary

Gastric mucosal inflammation has the potential to promote the proliferation of gastric mucosal epithelial cells and inhibit their apoptosis. However, Si-Jun-Zi decoction may exert a therapeutic effect on these process via the multi-target network level.

Abstract

Objective: To find out the potential mechanisms of Si-Jun-Zi (SJZ) decoction in the treatment of gastric precancerous lesions (GPL). Methods: A network pharmacology approach was used to analyze the active compounds, drug targets and interacting pathways of SJZ decoction in treating GPL. The compounds and predicted targets of SJZ decoction were screened from TCMSP, and the disease targets were obtained from GeneCards. The therapeutic mechanisms of action of the SJZ decoction were analyzed by gene ontology (GO) enrichment, Kyoto encyclopedia of genes and genomes pathway enrichment analyses. Results: The results show that 111 compounds and 90 targets were obtained in this work. These targets were further mapped to 654 GO biological process terms and 21 remarkably pathways. Active compounds, targets, and pathways were used to construct a compound-target network, a target-pathways network, and an integrated GPL pathway. These results indicated that SJZ decoction may treat the dysfunctions of GPL mainly from intervening in the mucosal inflammation, cell apoptosis process, and cell proliferation. Conclusion: This work provided a novel approach to understand the pathogenesis of GPL and revealed the therapeutic mechanisms of SJZ decoction, which facilitate the modernization of herbal medicine for complex diseases in the future.

基于伤寒六经辨证之三阴病辨治溃疡性结肠炎理论探讨
徐晓
经典中医研究    2018, 1 (1): 1-4.   https://doi.org/10.12032/CCMR20180101
Abstract ( 1178 PDF (790KB) ( 595 )  
溃疡性结肠炎是病因不明的难治性疾病,现代医学应用糖皮质激素、 甚至生物制剂可以有效缓解炎症反应,控制病情,但是此类药物需长期应用并且可导致肝肾损害、使人体长期处于免疫抑制状态等副作用日渐明显,临床观察采用中西医结合方法治疗溃结取得显著疗效,本文尝试从《伤寒论》六经之三阴病角度阐述溃疡性结肠炎各个阶段的病理变化,意为启发思维。
基于六经模型对太阴虚劳小建中汤条文的探讨
沈佳
经典中医研究    2018, 1 (1): 13-17.   https://doi.org/10.12032/CCMR20180104
Abstract ( 1065 PDF (784KB) ( 514 )  
对仲景太阴虚劳小建中汤条文的理解,学术界有多种看法,本文基于六经模型,结合《伤寒论》与《金匮要略》相关条文,对小建中汤条文进行探讨,以期剖析其内在含义。
Leech therapy indications: a scoping review
Roshanak Ghods, Mojtaba Abdi, Matineh Pourrahimi, Fataneh Hashem Dabaghian
1Traditional Medicine Research    2019, 4 (3): 118-130.   https://doi.org/10.12032/TMR20190225105
Abstract ( 855 HTML PDF (468KB) ( 375 )  

Highlights

The present scoping review provides evidence for the application of leech therapy in the treatment of plastic and reconstructive surgery, musculoskeletal diseases, osteoarthritis, etc..

Traditionality

The first recorded report of the use of leeches is in a medical poem, Alexipharma, for Nicander of Colophon, born 200 B.C.. There is also evidence of the using leeches by large scholars such as Avicenna in The Canon of Medicine and Abd-el-Latif al-Baghdadi in Al-Mukhtarat fi al-Tibb. Barbers-surgeons in the middle ages used to use leeches to shed blood for treating some kind of diseases. With the development of modern medicine, the first use of medical leeches occurred in the 1960's, for intravenous congestion after reconstructive surgery. In 2004 the FDA approved leech therapy to accelerate tissue transplantation.

Abstract

After the developments of modern medicine, leeches were not used as before, but in the late nineteenth century, leeches were still being used in many countries around the world. Until now, leeches have been used to treat a wide range of diseases. The present study, is a scoping review of the evidence of the indication of leech therapy. The results of this study are based on English articles and dissertations published in databases from 2000 up to July 10, 2017. The results showed that leech therapy could be used in different conditions including venous congestion in plastic and reconstructive surgery, osteoarthritis, cardiovascular diseases due to blood coagulation disorders, migraine headache, skin disorders, diabetic foot ulcers, macroglossia, priapism, cancer complications, and wounds. More researches are needed in wider areas with more precise methodologies to ensure the potential therapeutic effects of leech therapy.

中医治疗肺神经内分泌癌 1 例体会
莫艳芳
经典中医研究    2018, 1 (1): 18-22.   https://doi.org/10.12032/CCMR20180105
Abstract ( 852 PDF (738KB) ( 337 )  
肺神经内分泌癌的治疗以手术为主,但对于不能或拒绝手术的患者,中医中药作为一种治疗手段,也显示出了良好的疗效和优势。在此医案中,单纯应用中医治疗,临床症状得到改善,抑制肿瘤进一步发展,效果显著,现对其做一总结。
Annual advances of integrative pharmacology in 2018
Ke-Wu Zeng
1Traditional Medicine Research    2019, 4 (2): 56-67.   https://doi.org/10.12032/TMR20190304106
Abstract ( 844 HTML PDF (464KB) ( 292 )  

Highlights

This review covers the research progress during 2018 for pharmacological studies on traditional medicine and active natural products. The pharmacological reports on traditional medicine against cancers and diabetes were still hot issues.

Traditionality

This annual integrative pharmacology review analyzed the different growth rates and progress of traditional medicine in different diseases, which is able to provide a comprehensive description of the hot spot and development.

Abstract

A number of researches concerning pharmacology of traditional medicine and active natural products over the past 12 months have outlined the importance of reviewing the progress. This annual integrative pharmacology review evaluates researches published during 2018 in different diseases including cardiovascular and cerebrovascular diseases, cancers, diabetes and metabolic diseases, and so on. The emphasis is on bioactive compounds and extracts from traditional herbs, as well as the novel molecular targets and mechanisms. Moreover, some traditional prescriptions in China and other geographical locations have also been included.