Top Read Articles
Published in last 1 year |  In last 2 years |  In last 3 years |  All
Please wait a minute...
Traditional Chinese medicine for treatment of coronavirus disease 2019: a review
Huan-Tian Cui, Yu-Ting Li, Li-Ying Guo, Xiang-Guo Liu, Lu-Shan Wang, Jian-Wei Jia, Jia-Bao Liao, Jing Miao, Zhai-Yi Zhang, Li Wang, Hong-Wu Wang, Wei-Bo Wen
1Traditional Medicine Research    2020, 5 (2): 65-73.   https://doi.org/10.12032/TMR20200222165
Abstract ( 4370 HTML PDF (543KB) ( 1616 )  

Highlights

Coronavirus disease 2019 (COVID-19) has recently become a public health concern worldwide. The use of traditional Chinese medicine (TCM) may have substantial impact on COVID-19. In this review, we summarize the disease pathogenesis, clinical outcomes, and current applications of TCM for the treatment of COVID-19.

Traditionality

The pathogenesis and clinical symptoms related to severe respiratory disease were described many years ago in TCM texts. The ancient book of TCM Huang Di Nei Jing (Inner Canon of Huangdi) was written during the Western Han Dynasty of China (dated approximately 99 B.C.E.-26 B.C.E.); the text recorded a plague that could transmit disease from human-to-human with symptoms that were similar to those described for COVID-19. Three additional texts, notably Shang Han Za Bing Lun (Treatise on Cold Damage Diseases) written by Zhang Zhongjing (200 C.E.-210 C.E.), Wen Yi Lun (Theory of Plague) and Wen Re Lun (Translated Theory of Warm) written by Wu Youke (1642 C.E.), recorded therapies and formulas that were effective at treating infectious diseases; among them, the classical prescription Da Yuan Yin and the use of human variolation were considered as means to prevent smallpox. Currently, the use of TCM has resulted in remarkable improvement and alleviation of symptoms in COVID-19 patients.

Abstract

Since late December in 2019, the coronavirus disease 2019 has received extensive attention for its widespread prevalence. A number of clinical workers and researchers have made great efforts to understand the pathogenesis and clinical characteristics and develop effective drugs for treatment. However, no effective drugs with antiviral effects on severe acute respiratory syndrome coronavirus 2 have been discovered currently. Traditional Chinese medicine (TCM) has gained abundant experience in the treatment of infectious diseases for thousands of years. In this review, the authors summarized the clinical outcome, pathogensis and current application of TCM on coronavirus disease 2019. Further, we discussed the potential mechanisms and the future research directions of TCM against severe acute respiratory syndrome coronavirus 2.

Traditional Chinese medicine for novel coronavirus pneumonia treatment: main force or supplement?
Mi Li, Xue Yang, Kai Li, Yi-Qiang Xie
1Traditional Medicine Research    2020, 5 (2): 62-64.   https://doi.org/10.12032/TMR20200204158
Abstract ( 2529 HTML PDF (456KB) ( 559 )  
The National Health Commission of the People's Republic of China and the National Administration of Traditional Chinese Medicine of the People's Republic of China issued a diagnosis and treatment plan (trial version 4th) for novel coronavirus pneumonia on January 27, 2020, providing specific recommendations for the treatment and prevention of the infection using TCM. Academician Zhang Boli, the President of the Tianjin University of Traditional Chinese Medicine, stated the following in an interview with Xinhua News Agency: “Chinese medicine plays an all-round role throughout the treatment of novel coronavirus pneumonia, but I still advocate integrated Chinese and Western medicine” . However, interestingly, on the same day, the famous The New York Times put forward a contrasting view on the use of TCM for the treatment of this infection. The report quoted the opinion of Dominic Dwyer, a medical virologist at the University of Sydney, who said, “There has never been a good antiviral agent, so that means that people would try things that have some effect. But there’s no evidence of significant benefits with any antiviral drugs or TCM” .
Effects of music therapy in depression and anxiety disorder
Ednaldo Antonio dos Santos, Esperanza Marchant Sanchez, Maria Angeles Niguez Ortiz, Maria Amparo Oliver Germes
90Life Research    2019, 2 (2): 64-70.   https://doi.org/10.12032/life2019-0425-003
Abstract ( 1431 HTML PDF (1019KB) ( 549 )  

Mental disorders are considerate "the evil of the century" by renowned researchers, because a large part of the population in many countries is a diagnosticated, and currently affect youth and children. Among the numerous therapeutic interventions, the music therapy is a non-invasive approach. However, there are very few people who are professionally engaged in research and studies on the subject. Therefore, this article is a literature to talk about the benefits of music therapy sessions for people with stress, depression and anxiety disorders.

Leech therapy indications: a scoping review
Roshanak Ghods, Mojtaba Abdi, Matineh Pourrahimi, Fataneh Hashem Dabaghian
1Traditional Medicine Research    2019, 4 (3): 118-130.   https://doi.org/10.12032/TMR20190225105
Abstract ( 1430 HTML PDF (468KB) ( 568 )  

Highlights

The present scoping review provides evidence for the application of leech therapy in the treatment of plastic and reconstructive surgery, musculoskeletal diseases, osteoarthritis, etc..

Traditionality

The first recorded report of the use of leeches is in a medical poem, Alexipharma, for Nicander of Colophon, born 200 B.C.. There is also evidence of the using leeches by large scholars such as Avicenna in The Canon of Medicine and Abd-el-Latif al-Baghdadi in Al-Mukhtarat fi al-Tibb. Barbers-surgeons in the middle ages used to use leeches to shed blood for treating some kind of diseases. With the development of modern medicine, the first use of medical leeches occurred in the 1960's, for intravenous congestion after reconstructive surgery. In 2004 the FDA approved leech therapy to accelerate tissue transplantation.

Abstract

After the developments of modern medicine, leeches were not used as before, but in the late nineteenth century, leeches were still being used in many countries around the world. Until now, leeches have been used to treat a wide range of diseases. The present study, is a scoping review of the evidence of the indication of leech therapy. The results of this study are based on English articles and dissertations published in databases from 2000 up to July 10, 2017. The results showed that leech therapy could be used in different conditions including venous congestion in plastic and reconstructive surgery, osteoarthritis, cardiovascular diseases due to blood coagulation disorders, migraine headache, skin disorders, diabetic foot ulcers, macroglossia, priapism, cancer complications, and wounds. More researches are needed in wider areas with more precise methodologies to ensure the potential therapeutic effects of leech therapy.

Sleep Paralysis - Cultural Significance and Its Management
Javed Ather Siddiqui, Shazia Farheen Qureshi, Abdul Khaliq Alghamdi, Waseem M Marei
92Psychosomatic Medicine Research    2019, 1 (2): 19-25.   https://doi.org/10.12032/psmr2019-0920-007
Abstract ( 1072 PDF (259KB) ( 1414 )  
Sleep paralysis (SP) is a benign, transient episode of immobility and it lasts a few seconds to a few minutes. It can occur while falling asleep or on awakening. It is a condition of unknown etiology and all the skeletal muscles are almost ‘paralyzed’. It leads to an inability to speak or move but individual remains conscious. This review summarizes the existential clinical literature on sleep paralysis most relevant to practitioners; also summarizes the many historical and artistic manifestations of SP in different cultures. It also throws light on the available Arabic literature and others as per the aim of the review. For this review, literature search using engines was carried out, and review papers and original research articles were analyzed. We will start with a review which summarizes the collection of symptoms, prevalence rate, risk factors and etiological theories, characteristics and classification of the SP over the past years up to the present time, also the management in the form of psychotherapy and pharmacotherapy as well as the cultural significances in different countries. SP plays an important role in the genesis and maintenance of many supernatural beliefs such as nocturnal alien abductions, demonic and ghost attacks in individuals with intact reality testing.
《古今录验》续命汤治疗急性大面积脑梗死体会
周天梅, 陈坤飞, 樊雅丽, 袁荣金
经典中医研究    2019, 2 (2): 23-26.   https://doi.org/10.12032/CCMR20190201
Abstract ( 1071 PDF (737KB) ( 798 )  
通过《古今录验》续命汤加减治疗急性大面积脑梗死病例,分析其病因病机,阐述其合 理性与重要性。续命汤寒温并用,补泻兼施,效果显著。此方既切中中国传统医学的病机学说, 也符合现代医学的发病机理,确是治疗中风之良方。
The differences and similarities between regional ethnic medicine and traditional Chinese medicine in the prevention and treatment of cancer pain
Hui-Li Shui, Zhu Yang , Feng-Xi Long , Wen-Qi Huang , Bing Yang , Zhen Zhang , Dong-Xin Tang
93TMR Cancer    2019, 2 (3): 206-211.   https://doi.org/10.12032/TMRC201800044
Abstract ( 1025 HTML PDF (576KB) ( 627 )  

Highlights

Regional ethnic medicine (REM) and traditional Chinese medicine (TCM) have unique experience in the treatment of cancer pain.

There are many different aspects of the treatment of cancer pain in REM and TCM.

Comments

TCM and REM are important cancer-assisted treatments in China. Especially for the treatment of cancer pain, TCM and REM are important alternatives.

Abstract

REM and TCMare both important parts of traditional medicine in China, and they have their own characteristics in the understanding and prevention of diseases. This article compares the understanding, the theoretical prevention and treatment guidance and the clinical application of the REM and TCMon the cancer pain.

Acupuncture preconditioning protects against myocardial ischemia/reperfusion injury mediated apoptosis through miR-214/NCX1 activation: a hypothesis
Hai-Long Fan, Yu-Lan Ren, Li-Zhen Yang, Fei Wu
1Traditional Medicine Research    2019, 4 (4): 178-183.   https://doi.org/10.12032/TMR20190306109
Abstract ( 1007 HTML PDF (397KB) ( 322 )  

Highlights

This review provides evidences for the recommendation of acupuncture preconditioning at Neiguan (PC6) point in coronary heart disease patients as a non-pharmacological therapeutic method to activate the miR-214/NCX1 pathway.

Traditionality

The concept of acupuncture preconditioning is described in the ancient book of Fan Wang Fang (Eastern Jin Dynasty of China). It refers to the application of acupuncture before the occurrence of disease or when the disease is relatively mild. According to the record of the ancient book of Huang Di Nei Jing (Qin Han Period of China, 475 B.C.-221 B.C.), acupuncture at Neiguan (PC6) point can prevent and treat angina pectoris in coronary heart disease (CHD). The WHO also recommends acupuncture as one of the alternative and complementary therapies for the prevention and treatment of angina pectoris in CHD.

Abstract

Early reperfusion of ischemic cardiac tissue is usually the best option to improve clinical outcome of angina pectoris, especially of acute myocardial infarction. However, myocardial reperfusion may cause an abnormal increase of intracellular Ca2+-mediated cardiomyocyte death and consequent loss of cardiac function, which is referred to myocardial ischemia/reperfusion (I/R) injury. Recently, the microRNA-214 (miR-214)/Na+/Ca2+ exchanger (NCX) 1 co-expression is a key factor in cellular protection against myocardial apoptosis for myocardial I/R injury. Once activated, miR-214/NCX1 axis can inhibit several Ca2+ downstream signaling effectors that mediate cell death simultaneously. Studies have shown that acupuncture preconditioning has a protective effect on myocardial I/R injury, but its mechanism deserves further research. It has been proved that acupuncture preconditioning for ischemic myocardium successfully inhibit multiple Ca2+ handling related microRNAs that mediate cell death pathways, and miR-214 is one of its targets. In terms of clinical practice, coronary heart disease (CHD) patients benefit a lot from this intervention. However, there is barely no study correlating acupuncture preconditioning to the miR-214/NCX1 co-expression in patients with CHD. This review aims to discuss whether there is some evidence to justify a recommendation of acupuncture preconditioning in CHD patients as a non-pharmacological therapeutic method to activate the miR-214/NCX1 co-expression network model.

Natural products as a crucial source of anti-inflammatory drugs: recent trends and advancements
Yan-Hang Wang, Ke-Wu Zeng
1Traditional Medicine Research    2019, 4 (5): 257-268.   https://doi.org/10.12032/TMR20190831133
Abstract ( 931 HTML PDF (758KB) ( 405 )  

Highlights

This review introduced the current major anti-inflammatory natural active molecules based on their chemical structures, and discussed their pharmacological mechanisms.

Abstract

Natural active molecules are key sources of modern innovative drugs. Particularly, a great amount of natural active molecules have been reported to possess promising therapeutic effects on inflammatory diseases, including asthma, rheumatoid arthritis, hepatitis, enteritis, metabolic disorders and neurodegenerative diseases. However, these natural active molecules with various molecular structures usually exert anti-inflammatory effects through diversiform pharmacological mechanisms, which is necessary to be summarized systematically. In this review, we introduced the current major anti-inflammatory natural active molecules based on their chemical structures, and discussed their pharmacological mechanisms including anti-inflammatory molecular signaling pathways and potential target proteins, which providing a referential significance on the development of novel anti-inflammatory drugs, and also revealing new therapeutic strategies for inflammatory diseases.