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吴门验方 “ 阳和散结汤 ” 治疗乳腺癌理论浅析
成艳丽 彭涛 张国华
经典中医研究    2018, 1 (1): 9-12.   https://doi.org/10.12032/CCMR20180103
Abstract ( 2725 PDF (861KB) ( 665 )  
乳腺癌是女性最高发的恶性肿瘤,其发病率逐年上升,严重危害女性身心健康。吴雄志教授从事中医临床工作近 20 年,对肿瘤疾病有深刻的认识,所拟吴门验方 阳和散结汤 注重乳腺癌的病因与病位,采用中西汇通的思想,提高了对乳腺癌的治疗效果。
泽漆汤在肺癌治疗中的加减应用
彭涛
经典中医研究    2018, 1 (1): 5-8.   https://doi.org/10.12032/CCMR20180102
Abstract ( 2487 PDF (668KB) ( 591 )  
《金匮要略》泽漆汤治疗肺癌有一定临床疗效。笔者学习吴雄志教授使用泽漆汤治疗肺癌的理论和医案,结合自己临床使用的经验,从方药解析、合方加减、专病专药三方面展开论述,简要阐明泽漆汤在肺癌治疗中的方义和加减变化。
Whether Chinese physiognomy has scientific basis?
Life Research editorial group
90Life Research    2018, 1 (1): 30-31.   https://doi.org/10.12032/life2018-0711-006
Abstract ( 2007 HTML PDF (798KB) ( 476 )  
The implicit stress of eating meat
Christopher Anthony David, Peter Gerard Coan
90Life Research    2018, 1 (1): 9-17.   https://doi.org/10.12032/life2018-0711-003
Abstract ( 1436 HTML PDF (6125KB) ( 318 )  

This paper gives a brief overview of the evolutionary history of human diet, discusses various reasons why some modern humans choose to abstain from eating animal products, and explores the psychological effects occasioned by the eating of meat. The authors argue that when modern, scientifically literate humans choose to eat meat and animal-milk-based products, while being simultaneously aware of the associated poor outcomes in terms of personal health, environmental sustainability, and animal suffering, then psychological stress is an inevitable outcome. They highlight some key recent additions to the growing body of evidence which demonstrates that the choice to eat meat is a factor in environmental destruction, animal misery, and personal health risks, and explore the causes and consequences of the predictable psychological stresses that result for those individuals who continue to habitually eat meat.

Advances in the relationship between Hashimoto’s thyroiditis and thyroid cancer
Yu Qiao
93TMR Cancer    2018, 1 (3): 66-73.   https://doi.org/10.12032/TMRC201800031
Abstract ( 1384 HTML PDF (883KB) ( 434 )  

Highlights: In this paper, various factors related to Hashimoto’s thyroiditis and thyroid cancer, especially papillary thyroid cancer, morbidity and lymph node metastasis, are reviewed concerning recent literature.

Editor’s Summary: In recent decades, it is very high for the incidence of HT and the thyroid cancer rate. This article is more likely that autoimmune thyroid inflammation such as HT is carcinogenic, and thyroid dysfunction related to HT may also promote tumor growth induced by stimulating TSH receptor.

Abstract: In recent years, the incidence of Hashimoto’s thyroiditis and thyroid cancer has shown a rapid growth trend. These two diseases have severely affected the public health. Many epidemiological studies have shown that thyroid cancer is often associated with Hashimoto’s thyroiditis. Hashimoto’s thyroiditis may promote the occurrence of thyroid cancer, as well as affecting the progression of the tumor, lymph node metastasis, and even the prognosis of patients. In this paper, the relationship between Hashimoto’s thyroiditis and thyroid cancer and the pathogenesis of thyroid cancer are reviewed regarding molecular mechanism, clinical pathology, and serology.

Rat model for study of the essence of spleen deficiency and dampness in Chinese medicine
Xiao-Chun Han, Xu-Ming Ji, Lin Liu, Shuang Zhang, Li Sun, Qiu-Jian Feng, Shi-Jun Wang
Traditional Medicine Research    2018, 3 (5): 251-257.   https://doi.org/10.12032/TMR201813084
Abstract ( 1267 HTML PDF (1006KB) ( 284 )  

Highlights

Spleen deficiency is often accompanied by dampness. Cytokines, immunoglobulins, and gastrointestinal hormones play major roles in the pathogenesis of spleen deficiency and dampness.

Editor’s Summary

The two TCM syndromes “spleen deficiency” and “dampness” were cause and effect to each other.

Abstract

Objective: To explore the essence of spleen deficiency and dampness in Chinese medicine by successfully constructing a rat model with this syndrome. Methods: Rat models with the syndrome of dampness and spleen deficiency were established with the use of a high-fat, low-protein diet and excessive fatigue induced by loaded swimming. A total of 25 common clinical serological markers were tested. The T test, rank test, and partial least squares regression-discriminant analysis were used to analyze the data. Results: Total protein, albumin, motilin, interferon-γ, interleukin-2, immunoglobulin A, immunoglobulin G, and complement 3 levels in the model rats were lower than those in the control group (P = 0.029, P = 0.032, P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, respectively). The serum creatinine, total cholesterol, aldosterone, antidiuretic hormone, gastrin, interleukin-4, somatostatin, atrial natriuretic peptide, and vasoactive intestinal peptide levels in the model group were higher than those in the control group (P < 0.001, P = 0.015, P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, respectively). There was no statistical difference between the two groups in aspartate transaminase, alanine aminotransferase, globulin, albumin/globulin, blood urea nitrogen, high-density lipoprotein, and low-density lipoprotein. The model animal syndrome used two important variables in analysis with partial least squares regression-discriminant analysis. At the same time, the two dimensions were difficult to distinguish for each biological index. Conclusion: Spleen deficiency is often associated with dampness. The index that represents spleen deficiency can also represent dampness. Cytokines, immunoglobulins, and gastrointestinal hormones play a major causative role in both spleen deficiency and dampness.

Evaluating the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis combined with infertility
Hua Wang, Yan Chen, Yong Yin, Chun-Hua Cao, Sai-Li Wang, Qin Wang, De-Xi Peng, Chun-Jian Zhu, Lin-Wei Chen
Traditional Medicine Research    2018, 3 (5): 243-250.   https://doi.org/10.12032/TMR201813083
Abstract ( 1113 HTML PDF (334KB) ( 220 )  

Highlights

Thunder-Fire moxibustion with ovulation monitoring significantly improved the pregnancy rate of patients diagnosed with adenomyosis- associated infertility.

Editor’s Summary

Thunder-Fire moxibustion stemmed from the Taoism magic arts before the Yuan Dynasty of China (1271 A.D.-1368 A.D.) and took shape in the middle of the Ming Dynasty of China (1368 A.D.-1644 A.D.).

Abstract

This study evaluated the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring for the treatment of adenomyosis-associated infertility. A series of 120 patients diagnosed with uterine adenomyosis and infertility and cold coagulation blood stasis syndrome in traditional Chinese medicine (with the clinical manifestations of premenstrual or menstrual lower abdomen cold pain, pain reduction with heat application, and cold extremities) were randomized equally to treatment group with Thunder-Fire moxibustion and ovulation monitoring as well as control group with ovulation monitoring only. Treatment continued for six menstrual cycles. The pregnancy rate of the treatment group was significantly increased with the control group (50.0% vs. 23.3%, P = 0.021). Dysmenorrhea and the traditional Chinese medicine syndrome in the treatment group improved significantly compared with the control group (3.87 ± 2.03 vs. 5.70 ± 1.01, P = 0.002 and 7.33 ± 4.11 vs. 10.52 ± 2.33, P = 0.006, respectively), and there was also significant between-group differences in serum cancer antigen 125 (55.45 ± 14.65 vs. 63.34 ± 11.41, P = 0.031). However, the average uterus diameters in the treatment and control groups were not significantly different (67.13 ± 7.59 vs. 69.89 ± 5.30, P = 0.137). Thunder-Fire moxibustion with ovulation monitoring improved the pregnancy rate of patients diagnosed with adenomyosis-associated infertility.

柴苓汤治疗 2 例儿童支原体肺炎的观察
李玉林
经典中医研究    2019, 2 (1): 14-17.   https://doi.org/10.12032/CCMR20190104
Abstract ( 1048 PDF (1206KB) ( 575 )  
目的 : 使用小柴胡汤合上五苓散(柴苓汤)治疗支原体肺炎。方法 : 小柴胡汤和解少阳枢机,五苓散通调三焦水道,从水液输布代谢链治疗支原体肺炎。结果 :2 例支原体肺炎患儿使用柴苓汤后,体温恢复正常,肌体不适感消除。结论 : 柴苓汤治疗支原体引发的儿童高热、咳嗽、肺炎疗效确切,合方有效
Long-term effect of Chinese herbal medicine Tianqi Capsule on the incidence of diabetes: an 8-year cohort study protocol
Bing Pang, Chun-Yong Han, Qing-Hu He, Jing Liu, Qing-Wei Li, Yu-Jiao Zheng, Feng-Mei Lian, Xiao-Lin Tong
Traditional Medicine Research    2018, 3 (4): 166-172.   https://doi.org/10.12032/TMR201812075
Abstract ( 1031 HTML PDF (449KB) ( 214 )  

Highlights
The protocol attempted to systematically assess the long-term efficacy of Tianqi capsule for prevention of T2DM.

Editor’s Summary
Tianqi capsule is an approved natural TCM compound in China (Approved No. Z20020089). This study may provide evidence for the long-term effect of Tianqi capsule intervention to prevent T2DM in people with impaired glucose tolerance.

Abstract
Background:The rapid growth of type 2 diabetes mellitus (T2DM) remains a big challenge for clinicians worldwide. Traditional Chinese medicine may bring a new approach for solving this problem. The Tianqi Capsule Diabetes Prevention Study (REDUCES Study) reported that 1 years of therapy with Tianqi capsule reduced the risk of diabetes by 32.1% compared with the placebo. Here we aimed to assess the long-term effect of Tianqi capsule on prevention of T2DM in people with impaired glucose tolerance after discontinuation of active intervention. Methods/design: 420 subjects will be followed-up for 8 years to assess the long-term effect of Tianqi capsule intervention. The causes of death and the status of living subjects will be investigated. Follow-up data for living subjects will be collected by personal interview and clinical examination and medical record review to determine diabetes status. Questionnaires will be given to all the subjects to investigate the factors that probably affect the diabetes status during the 8-year of discontinuation of intervention. The primary outcome is the incidence of T2DM, and the secondary outcomes are body mass index, blood glucose, blood lipids and blood pressure. The Cox proportional hazards model will be used to estimate the hazard ratio for diabetes incidence. Analyses will be done with SAS 8.2 software package. Discussion: Results from this study may provide evidence for the long-term efficacy of Tianqi capsule in patients with prediabetes. The findings will provide a basis for further confirmatory studies. Ethics: The protocol has been approved by the Medical Ethics Committee of Guang’anmen Hospital of China Academy of Chinese Medical Sciences (approval number 2016-046-KY-01). Study registration number: ClinicalTrials.gov; NCT02848053.

A network pharmacology approach to investigate the mechanisms of Si-Jun-Zi decoction in the treatment of gastric precancerous lesions
Liang-Jun Yang, Dao-Rui Hou, Ya Li, Zhi-Peng Hu, Yong Zhang
Traditional Medicine Research    2018, 3 (6): 273-285.   https://doi.org/10.12032/TMR201814087
Abstract ( 959 HTML PDF (1672KB) ( 528 )  

Highlights

The Si-Jun-Zi decoction may exert a therapeutic effect on gastric precancerous lesions by intervening in the mucosal inflammation, cell apoptosis process, and cell proliferation.

Editor’s Summary

Gastric mucosal inflammation has the potential to promote the proliferation of gastric mucosal epithelial cells and inhibit their apoptosis. However, Si-Jun-Zi decoction may exert a therapeutic effect on these process via the multi-target network level.

Abstract

Objective: To find out the potential mechanisms of Si-Jun-Zi (SJZ) decoction in the treatment of gastric precancerous lesions (GPL). Methods: A network pharmacology approach was used to analyze the active compounds, drug targets and interacting pathways of SJZ decoction in treating GPL. The compounds and predicted targets of SJZ decoction were screened from TCMSP, and the disease targets were obtained from GeneCards. The therapeutic mechanisms of action of the SJZ decoction were analyzed by gene ontology (GO) enrichment, Kyoto encyclopedia of genes and genomes pathway enrichment analyses. Results: The results show that 111 compounds and 90 targets were obtained in this work. These targets were further mapped to 654 GO biological process terms and 21 remarkably pathways. Active compounds, targets, and pathways were used to construct a compound-target network, a target-pathways network, and an integrated GPL pathway. These results indicated that SJZ decoction may treat the dysfunctions of GPL mainly from intervening in the mucosal inflammation, cell apoptosis process, and cell proliferation. Conclusion: This work provided a novel approach to understand the pathogenesis of GPL and revealed the therapeutic mechanisms of SJZ decoction, which facilitate the modernization of herbal medicine for complex diseases in the future.