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The applications of Bayesian models in real-world studies of traditional Chinese medicine: a primer
Zhai Jing-Bo, Li Jiang, Chen Jing
Traditional Medicine Research    2017, 2 (2): 88-93.   https://doi.org/10.12032/TMR201706042
Abstract ( 386 HTML PDF (244KB) ( 921 )  

Highlights:

Real-world study is valuable for traditional Chinese medicine. However, there are no gold standards of statistical approaches for analyzing data from real-world study of traditional Chinese medicine. In the present study, we discussed why and when to use Bayesian analysis and the challenge in the real-world study of traditional Chinese medicine.

Abstract

Real-world study is valuable for traditional Chinese medicine. However, there are no gold standards of statistical approaches for analyzing data from real-world study of traditional Chinese medicine. With the development of computer technology, researchers have increasingly paid attention to Bayesian statistics in the biomedical field. In present study, real-world study and Bayesian statistics were introduced. It was discussed that why and when to use Bayesian analysis and the challenge in the real-world study of traditional Chinese medicine.

吴门验方 “ 阳和散结汤 ” 治疗乳腺癌理论浅析
成艳丽 彭涛 张国华
经典中医研究    2018, 1 (1): 9-12.   https://doi.org/10.12032/CCMR20180103
Abstract ( 2864 PDF (861KB) ( 695 )  
乳腺癌是女性最高发的恶性肿瘤,其发病率逐年上升,严重危害女性身心健康。吴雄志教授从事中医临床工作近 20 年,对肿瘤疾病有深刻的认识,所拟吴门验方 阳和散结汤 注重乳腺癌的病因与病位,采用中西汇通的思想,提高了对乳腺癌的治疗效果。
Economic impact of traditional medicine practice worldwide
V. Pejcic Ana, Jakovljevic Mihajlo B
1Traditional Medicine Research    2017, 2 (2): 60-74.   https://doi.org/10.12032/TMR201706039
Abstract ( 554 HTML PDF (483KB) ( 673 )  

Highlights:

This review implies that the expenditure on TM/CAM and its economic impact vary worldwide. Unfortunately, direct comparison of expenditures is limited due to the differences in the definitions of TM/CAM, inclusion of various forms of TM/CAM, use of different names and categorization, as well as differences in reported currencies and time periods in which data were collected. Despite this limitation this review still provides valuable insight into the economic impact of TM/CAM worldwide.

Abstract

The aim of this literature review was to summarize available findings from publications that reported expenditure on traditional/complementary and alternative medicine (TM/CAM) within a representative general population sample of a nation or a defined geographical area. A total of 24 publications met the inclusion criteria and were included in the review. The expenditure on TM/CAM varies worldwide, but direct comparison of the findings of publications included in this review is limited due to the differences in the definitions of TM/CAM, inclusion of various forms of TM/CAM, use of different names and categorization, as well as differences in reported currencies and time periods in which data were collected. Data about the expenditure on TM/CAM in most countries throughout the world are scarce. Further national studies should be conducted in order to provide up-to-date assessment of the TM/CAM related expenditure patterns and use. Uniform nomenclature, definition of TM/CAM and standardized instruments would provide basis for comparability of data of studies conducted in various regions and time periods.

泽漆汤在肺癌治疗中的加减应用
彭涛
经典中医研究    2018, 1 (1): 5-8.   https://doi.org/10.12032/CCMR20180102
Abstract ( 2609 PDF (668KB) ( 615 )  
《金匮要略》泽漆汤治疗肺癌有一定临床疗效。笔者学习吴雄志教授使用泽漆汤治疗肺癌的理论和医案,结合自己临床使用的经验,从方药解析、合方加减、专病专药三方面展开论述,简要阐明泽漆汤在肺癌治疗中的方义和加减变化。
A network pharmacology approach to investigate the mechanisms of Si-Jun-Zi decoction in the treatment of gastric precancerous lesions
Liang-Jun Yang, Dao-Rui Hou, Ya Li, Zhi-Peng Hu, Yong Zhang
Traditional Medicine Research    2018, 3 (6): 273-285.   https://doi.org/10.12032/TMR201814087
Abstract ( 1087 HTML PDF (1672KB) ( 612 )  

Highlights

The Si-Jun-Zi decoction may exert a therapeutic effect on gastric precancerous lesions by intervening in the mucosal inflammation, cell apoptosis process, and cell proliferation.

Editor’s Summary

Gastric mucosal inflammation has the potential to promote the proliferation of gastric mucosal epithelial cells and inhibit their apoptosis. However, Si-Jun-Zi decoction may exert a therapeutic effect on these process via the multi-target network level.

Abstract

Objective: To find out the potential mechanisms of Si-Jun-Zi (SJZ) decoction in the treatment of gastric precancerous lesions (GPL). Methods: A network pharmacology approach was used to analyze the active compounds, drug targets and interacting pathways of SJZ decoction in treating GPL. The compounds and predicted targets of SJZ decoction were screened from TCMSP, and the disease targets were obtained from GeneCards. The therapeutic mechanisms of action of the SJZ decoction were analyzed by gene ontology (GO) enrichment, Kyoto encyclopedia of genes and genomes pathway enrichment analyses. Results: The results show that 111 compounds and 90 targets were obtained in this work. These targets were further mapped to 654 GO biological process terms and 21 remarkably pathways. Active compounds, targets, and pathways were used to construct a compound-target network, a target-pathways network, and an integrated GPL pathway. These results indicated that SJZ decoction may treat the dysfunctions of GPL mainly from intervening in the mucosal inflammation, cell apoptosis process, and cell proliferation. Conclusion: This work provided a novel approach to understand the pathogenesis of GPL and revealed the therapeutic mechanisms of SJZ decoction, which facilitate the modernization of herbal medicine for complex diseases in the future.

柴苓汤治疗 2 例儿童支原体肺炎的观察
李玉林
经典中医研究    2019, 2 (1): 14-17.   https://doi.org/10.12032/CCMR20190104
Abstract ( 1190 PDF (1206KB) ( 610 )  
目的 : 使用小柴胡汤合上五苓散(柴苓汤)治疗支原体肺炎。方法 : 小柴胡汤和解少阳枢机,五苓散通调三焦水道,从水液输布代谢链治疗支原体肺炎。结果 :2 例支原体肺炎患儿使用柴苓汤后,体温恢复正常,肌体不适感消除。结论 : 柴苓汤治疗支原体引发的儿童高热、咳嗽、肺炎疗效确切,合方有效
Analysis on the principles of differentiation and prescription of traditional Chinese medicine in the treatment of cancerous fever
Xu Wei, Chai Ni, Cheng Yue-Lei, Yang Qiong, Zhu Hui-Rong
Traditional Medicine Research    2017, 2 (1): 41-50.   https://doi.org/10.12032/TMR201705036
Abstract ( 444 HTML PDF (286KB) ( 560 )  

Highlights:

Based on the published literatures of TCM treatment for cancerous fever, this study analyzed the principles of differentiation and prescription in treating cancerous fever by metrology statistics and Logistic regression analysis. It provided a reference for clinical treatment of cancerous fever.

Abstract

To investigate the principles of differentiation and prescription of traditional Chinese medicine (TCM) treatment for cancerous fever by logistic stepwise regression and literature investigation, the following databases were searched (from inception to June 30th 2016): CNKI, CSPD, CBM, PubMed, MEDLINE, EMBASE. According to the inclusion and exclusion criteria, literatures about TCM in the treatment of cancerous fever were screened. The frequency about cancerous fever of differential syndrome types, formulas and herbs were analyzed by logistic multiple regression analysis. The model about syndrome types and formula application of cancerous fever was established. The result showed formula prescriptions used most frequently were Qing-Hao-Bie-Jia decoction, Xiao-Chai-Hu decoction, Xue-Fu-Zhu-Yu decoction, Bai-Hu decoction, San-Ren decoction. The main syndrome types of cancerous fever were as follows: Toxic heat flourishing type, Yin deficiency type, Stagnation of damp-heat type, Qi-Yin deficiency type, Liver meridian depressed-heat type, Blood stasis type and Yang deficiency type. Based on regression equation of the syndrome types, the corresponding herbs of this seven syndrome types were Radix Bupleuri, Radix Paeoniae Alba and Scutellaria Baicalensis Georgi; Radix Bupleuri and Cortex Moutan; Radix Paeoniae Rubra and Radix Angelicae Sinensis; Rhizoma Pinelliae, Cortex Lycii Radicis and Radix Paeoniae Alba; Herba Artemisiae Annuae, Gypsum Fibrosum and Poria Cocos; Rhizoma Anemarrhenae, Scutellaria Baicalensis Georgi and Radix Codonopsis; Radix Bupleuri respectively. The results of Logistic regression analysis and frequency of herbs statistics can provide reference for differentiation and treatment of cancerous fever in clinical.

A systematic summary of natural compounds in Radix Glycyrrhizae
Ming Yang, Yi Jin, Li-Ping Yang
Traditional Medicine Research    2018, 3 (2): 82-94.   https://doi.org/10.12032/TMR201810067
Abstract ( 570 HTML PDF (1144KB) ( 552 )  

Highlights

This study provides a basis for further study on molecular mechanisms of anti-inflammatory, phlegm-expelling, cough- and pain-relieving activities of Gancao (Radix Glycyrrhizae).

Editor’s Summary

Gancao (Radix Glycyrrhizae) was first recorded in Shennongbencaojing, which was published in the third century A.D. (Han Dynasty of China).

Abstract

Objective: To accumulate data from studies on the compounds identified from Gancao (Radix Glycyrrhizae, GC), and then systematically summarize and classify these compounds according to their structural characteristics. Methods: Five databases (CNKI, VIP, Wanfang data, CBM, and Pubmed) were used to search for studies on the chemical structure of compounds from GC. The retrieval time of the respective databases was from their inception to March 2016. According to the inclusion and exclusion criteria, the papers were carefully screened, and the data were extracted. Results: A total of 653 compounds from GC were collated from 252 articles, including flavonols (n = 201) belonging to 10 subgroups, terpenes and saponins (n = 167), coumarins (n = 30) belonging to 3 subgroups, aliphatics (n = 206), aromatics (n = 35), and others (n = 14). The flavones, represented by liquiritin and liquiritigenin, were the most reported compounds isolated from GC, followed by terpenes and saponins such as glycyrrhizic acid and glycyrrhetinic acid. Conclusion: The more than 600 natural compounds in GC may be responsible for GC’s anti-inflammatory, phlegm-expelling, cough- and pain-relieving activities.

Advances in the relationship between Hashimoto’s thyroiditis and thyroid cancer
Yu Qiao
93TMR Cancer    2018, 1 (3): 66-73.   https://doi.org/10.12032/TMRC201800031
Abstract ( 1456 HTML PDF (883KB) ( 519 )  

Highlights: In this paper, various factors related to Hashimoto’s thyroiditis and thyroid cancer, especially papillary thyroid cancer, morbidity and lymph node metastasis, are reviewed concerning recent literature.

Editor’s Summary: In recent decades, it is very high for the incidence of HT and the thyroid cancer rate. This article is more likely that autoimmune thyroid inflammation such as HT is carcinogenic, and thyroid dysfunction related to HT may also promote tumor growth induced by stimulating TSH receptor.

Abstract: In recent years, the incidence of Hashimoto’s thyroiditis and thyroid cancer has shown a rapid growth trend. These two diseases have severely affected the public health. Many epidemiological studies have shown that thyroid cancer is often associated with Hashimoto’s thyroiditis. Hashimoto’s thyroiditis may promote the occurrence of thyroid cancer, as well as affecting the progression of the tumor, lymph node metastasis, and even the prognosis of patients. In this paper, the relationship between Hashimoto’s thyroiditis and thyroid cancer and the pathogenesis of thyroid cancer are reviewed regarding molecular mechanism, clinical pathology, and serology.

Metabonomics/metabolomics analysis technology and its application in quality control of traditional Chinese medicines
Yan Yu, Wang Shao-Hui, Wei Xu Dong, Ma Si-Bu, Liu Tong-Xiang
Traditional Medicine Research    2017, 2 (1): 1-7.   https://doi.org/10.12032/TMR201705031
Abstract ( 353 HTML PDF (271KB) ( 513 )  

Highlights:

This article systematically addresses metabolomics/metabonomics techniques and examples of their use in evaluation of traditional Chinese medicines. It provides a new reference for Chinese medicines and the identification and quality assessment of their products. In recent years, 1H-NMR metabonomics technology has matured. LC-MS and GC-MS metabonomics technologies have also evolved. These three analytical techniques have a good developing prospect on quality control and identification of species used in Chinese medicines, but this three techniques have their own advantages and disadvantages, Therefore, the future development should combine 1H-NMR technique with LC-MS, GC-MS techniques, and learn from each other in order to make greater contribution to the quality control of Chinese medicines.

Chinese medicines are an important part of traditional Chinese medicines, but their "safe, effective, stable and controllable" issue still remains to be solved. The rise of metabonomics in 20th century, consistent with the overall adjustment concept of multi-component, multi-level, multi-target, multi-metabolic pathways of traditional Chinese medicines, is conducive to solve basic problems in their quality control. This paper systematically describes recent application and development of 1H-NMR metabonomics techniques, LC-MS metabonomics techniques and GC-MS metabonomics techniques in the quality control of traditional Chinese medicines. It provides a new reference for Chinese medicines and the identification and quality assessment of their products.