Objective: This study was conducted to evaluate the clinical efficacy and safety of Kang-ai injection combined with chemotherapy in the treatment of ovarian cancer. Methods: the databases of VIP, CNKI, WanFang, CBM, Pub Med, Cochrane Library and EMBASE were searched to collect the randomized controlled trials (RCTs) of Kang-ai injection, combined with chemotherapy versus chemotherapy alone for the treatment of ovarian cancer. The retrieval time was from the database setup to December 20, 2018. After two researchers independently screened the researches, extracted data and evaluated the risk of the included studies, the RevMan 5.3 software was used for analysis. A total of 8 RCTS were included. Results: Results showed that patients in Kang-ai injection combined with chemotherapy group were superior to the conventional chemotherapy group patients in total effective rate [RR = 1.31, 95% CI (1.11, 1.54), P = 0.001], quality of life [RR = 1.69, 95% CI (1.35, 2.13), P < 0.001], leukopenia [RR = 0.63, 95% CI (0.51, 0.77), P < 0.001], nausea and vomiting [RR = 0.41, 95% CI (0.24, 0.70), P = 0.001], decreased hemoglobin [RR = 0.50, 95% CI (0.28, 0.88), P = 0.002], and thrombocytopenia [RR = 0.45, 95% CI (0.24, 0.85), P = 0.01]. Conclusion: Kang-ai injection combined with chemotherapy for ovarian cancer is better than chemotherapy alone in improving total effective rate and quality of life, reducing the incidence of adverse reactions. Limited by the number and quality of included studies, the above conclusions are yet to be verified by more high-quality studies.
Objective: To summarize the rule of application of traditional Chinese medicine (TCM) in the prevention and treatment of cervical cancer, and to explore the molecular mechanism of the compatibility of core herbs. Methods: Collect relevant literatures on cervical cancer in Chinese National Knowledgey Ifrastructure (CNKI), use TCM inheritance platform system (TCMISSV2.5) for association rules and complex system entropy clustering analysis; use BATMAN-TCM online analysis tools to construct target-pathway-disease network to reveal the underlying mechanisms of action. Results: Among the 78 prescriptions selected, a total of 172 Chinese medicines were used, and the five most frequently used herbs were Huang-bo (Phellodendri Chinrnsis Cortex), Fu-ling (Poria Cocos), Huang-qi (Hedysarum Multijugum Maxim.), Bai-hua-she-she-cao (Hedyotis Diffusae
Herba) and Gan-cao (Licorice). Bai-hua-she-she-cao (Hedyotis Diffusae Herba) and Huang-qi (Hedysarum Multijugum Maxim.), Bai-hua-she-she-cao (Hedyotis Diffusae Herba) and Fu-ling (Poria Cocos), Bai-zhu (Atractylodes Macrocephala Koidz.) and Fu-ling (Poria Cocos) are the three most commonly used medicine match. In addition, through cluster analysis, a total of 4 core herbs ompatibility and 2 new prescriptions were excavated. Herbs in the new prescriptions which are used to clearing heat-toxin and removing dampness were most frequently used. Through the analysis of
the signal pathway of high frequency Chinese medicines, we found that neuroactive ligand-receptor interaction pathway may play important roles. Conclusion: The core Chinese medicines for the prevention and treatment of cervical cancer are mainly clearing heat-toxin and removing dampness.
The core Chinese medicines may play their anti-cervical cancer by interfering with the neuroactive ligand-receptor interaction signaling pathway.
This paper proposed a hypothesis that grape (Vitis vinifera L.) could control threatened abortion due to its immunomodulatory and anti-inflammatory, anti-oxidant, anti-contraction, hormonal and anti-stress activities.
According to the records of traditional Persian medicine literatures, Grape (Vitis vinifera L.) had the function of fetal protection. Grape and grape molasses could produce good blood humor, the basic substances and fluids found in human body. As mentioned in Makhzan al-Advieh (1670 A.D.-1749 A.D.) and Tohfat al-Momenin (16th century), the leaf extract of Grapevine could prevent abortion. Rhazes, a great scientist of the 9th century A.D., also poineted out that unripe grapes juice could fortify the stomach of pregnant women and prevent the fetus from abortion in Al-Hawi (854 A.D.-925 A.D.) .
Threatened abortion is a common problem in early pregnancy. This early vaginal bleeding happens in about 25% of pregnant women. The medications including progesterone, uterine muscle relaxant or human chorionic gonadotropin have essential effects in developing pregnancy, but the clinical data are insufficient to prescribe them. In recent decades, medicinal herbs can help us to present new treatments. Grape (Vitis vinifera L.) can protect the fetus from the perspective of Persian medicine. So, we hypothesize about the salutary effects of grape in miscarriage prevention. We found five standard expected mechanisms of grape to prevent threatened abortion: immunomodulatory and anti-inflammatory, anti-oxidant, anti-contraction, hormonal and anti-stress activities. Grape reduces nitric oxide, prostaglandin E2, expression of nuclear factor κB and other pro-inflammatory cytokines like IL (Interleukin)-1β, IL-6, IL-8, and tumor necrosis factor-α. It also elevates anti-inflammatory mediators and expression of peroxisome proliferator-activated receptor-γ. Grape polyphenols have a crucial role in fetus protection with high antioxidant power and other functions such as prevention of stress-triggered abortion with proanthocyanidins, or hormonal effects and inhibition of uterine contractions with resveratrol. So according to these studies, grape probably has effects on the immune and endocrine factors involved in threatened miscarriage.
This report reviews the etiology, pathogenesis, treatment, and prevention of recurrent miscarriage discussed in the traditional Chinese medicine literature and lists the pharmacological studies that evaluated traditional Chinese medicine prescriptions for recurrent miscarriage.
The first cases of recurrent miscarriage as a fertility abnormality were reported in Chanjing, written during the Nanbei Dynasty of China (420 A.D. - 589 A.D.).
Recurrent miscarriage (RM) as a gynecological disorder was recognized by traditional Chinese medicine (TCM) practitioners long before the age of modern medicine. TCM physicians reported and recorded RM in the canonical TCM literature, which dates back more than 1500 years. The first cases of RM as a fertility abnormality were reported in Chanjing, which was written during the Nanbei Dynasty of China (420 A.D. - 589 A.D.). Some prescriptions for the treatment of RM are still actively used by modern TCM practitioners. In addition, many recent pharmacological and clinical studies have focused on the TCM therapy for RM. To identify the new therapeutic targets for RM and further promote the interest in treating RM with TCM, we reviewed the etiology, pathogenesis, treatment, and prevention of RM discussed both in the TCM literature and in contemporary pharmacological and clinical studies.
Neostigmine injections at the Zusanli (ST 36) acupoint have beneficial effects in treating postpartum urinary retention.
Acupoint injection is a developing method, which started in the 1950s, that combines acupuncture and medicine. This method enhances the effects of acupoint and medicine and reduces side-effects, leading to the use of this booming method in clinical practice.
Objective: We aimed to determine the effect of neostigmine injections given at the Zusanli (ST 36) acupoint when treating postpartum urinary retention. Methods: We conducted a systematic review to identify randomized controlled trials (RCTs) involving neostigmine injections given at the Zusanli (ST 36) acupoint for treating postpartum urinary retention. We searched the Cochrane Library, Pubmed, Web of Science, Chinese National Knowledge Infrastructure, Vip Database, and Chinese Biomedical Literature Database from the creation of the database to December 30, 2016. Bias risk assessment was performed using Revman 5.3 software from Cochrane based on the criteria set out in the Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0. Results: Thirteen studies were included with 627 participants in the treatment group and 584 participants in the control group. (1) Overall response rate: neostigmine injections given at the Zusanli (ST 36) acupoint have a better curative effect than injections given in muscle, odds ratio (OR) = 8.74, 95% confidence interval (CI) [5.83, 13.10], Z = 10.49 (P < 0.001); (2) Comparison of effects at different dosages: (i) 0.5 mg of neostigmine Zusanli (ST 36) acupoint injection group has better effect than 1 mg of neostigmine intramuscular injection group, OR = 15.84, 95% CI [5.74, 43.72],Z = 5.34 (P < 0.001), (ii) 0.5 mg of neostigmine injection given at the Zusanli acupoint has a better curative effect than 0.5 mg of neostigmine injection given in muscle , OR = 7.30, 95% CI [3.47, 15.34], Z = 5.24 (P < 0.001); (iii) 1 mg of neostigmine injection at the Zusanli (ST 36) acupoint has better efficacy than 1 mg of neostigmine injection in muscle, OR = 7.76, 95% CI [4.46, 13.52], Z = 7.25 (P < 0.001). Conclusion: Neostigmine injections at the Zusanli (ST 36) acupoint have beneficial effects in treating postpartum urinary retention. However, the low quality of the studies included in the meta-analysis raises questions over the reliability of the results. Further studies are still needed.
Thunder-Fire moxibustion with ovulation monitoring significantly improved the pregnancy rate of patients diagnosed with adenomyosis- associated infertility.
Thunder-Fire moxibustion stemmed from the Taoism magic arts before the Yuan Dynasty of China (1271 A.D.-1368 A.D.) and took shape in the middle of the Ming Dynasty of China (1368 A.D.-1644 A.D.).
This study evaluated the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring for the treatment of adenomyosis-associated infertility. A series of 120 patients diagnosed with uterine adenomyosis and infertility and cold coagulation blood stasis syndrome in traditional Chinese medicine (with the clinical manifestations of premenstrual or menstrual lower abdomen cold pain, pain reduction with heat application, and cold extremities) were randomized equally to treatment group with Thunder-Fire moxibustion and ovulation monitoring as well as control group with ovulation monitoring only. Treatment continued for six menstrual cycles. The pregnancy rate of the treatment group was significantly increased with the control group (50.0% vs. 23.3%, P = 0.021). Dysmenorrhea and the traditional Chinese medicine syndrome in the treatment group improved significantly compared with the control group (3.87 ± 2.03 vs. 5.70 ± 1.01, P = 0.002 and 7.33 ± 4.11 vs. 10.52 ± 2.33, P = 0.006, respectively), and there was also significant between-group differences in serum cancer antigen 125 (55.45 ± 14.65 vs. 63.34 ± 11.41, P = 0.031). However, the average uterus diameters in the treatment and control groups were not significantly different (67.13 ± 7.59 vs. 69.89 ± 5.30, P = 0.137). Thunder-Fire moxibustion with ovulation monitoring improved the pregnancy rate of patients diagnosed with adenomyosis-associated infertility.
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