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Effect of Transitional Care Model on Low Birth Weight Premature Infants: a meta-analysis
Ya-Nan Leng, Ming Sang, Ting-Ting Liu, Yu-Qi Li, Xiao-Li Pang
Medical Data Mining    2019, 2 (3): 90-99.   https://doi.org/10.12032/mdm2018021
Abstract PDF (520KB)  
Objective: To systematically review the effect of Transitional Care model (TCM) on the growth and development of premature infants. Methods: Randomized controlled trials (RCTs) or quasi-RTCs regarding the effect of TCM in low birth weight premature infants were retrieved in electronic databases such as the Cochrane Library, PubMed, EMbase, Web of Science, CBM (Chinese Biomedicine Database), CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database) and Wanfang Database. Then, we adopted RevMan 5.3 software to perform a meta-analysis. Results: A total of 11 articles were included, including 1282 preterm infants. The result showed that compared with the routine care model, TCM can effectively increase the weight when premature infants discharged one week [MD=225.57, 95%CI (171.78, 279.37), P<0.001], increase the weight after discharged one month [MD=0.89, 95%CI (0.72, 1.06), P<0.001], increase the weight after discharged three months [MD=670.44, 95%CI (527.65, 813.23), P<0.001], promote the height of newborns [MD=4.54, 95%CI (2.42, 6.65), P<0.001], reduce readmission rate [RR=0.38, 95%CI (0.25, 0.58), P<0.001], alleviate adverse skin reactions [RR=0.33, 95%CI (0.22, 0.50), P<0.001], increase nursing satisfaction of the families [RR=1.21, 95%CI (1.13, 1.31), P<0.001]. Conclusion: TCM can effectively promote the growth and development of the low birth weight premature infants, reduce the hospital readmission rate, alleviate adverse skin reactions of premature infants and improve the nursing satisfaction of the families. However, due to the limitation of the region and quality of the included studies, which the accuracy of the result still be treated with more caution. Further high-quality studies are needed to verify the conclusion.
The application effect of swaddling bath in neonates: A meta-analysis
Hui-Ping Wang, Chang-De Jin
92Medical Data Mining    2019, 2 (2): 84-89.   https://doi.org/10.12032/mdm2018017
Abstract PDF (493KB)  
Objective: The meta-analysis is to objectively evaluate the efficacy of swaddling in neonates. Methods: Randomized controlled trials (RCTs) and Randomized cross-over design (RCD) about the effects of swaddling in neonates from multiple electronic databases (PubMed, Web of Science, the Cochrane Library, EMBASE, CINAHL,CNKI, Wanfang and VIP) until January 2019. Two investigators independently screened eligible studies, extracted data, and assessed the methodological quality by using the quality evaluation criteria for RCTs recommended by Cochrane Handbook. Then data were analyzed by Rev Man 5.3. Results: A total of 6 papers (4 randomized controlled trials and 2 Randomized cross-over design) with 318 participants were included. The meta-analysis indicated that there was a significant difference on Body Temperature, Heart Rate, crying time, incidence of open eyes and incidence of closed eyes (P<0.05); There was no significant difference in Spo2 level between the two groups (p>0.05). Conclusion: Swaddling bath has little influence on the Body Temperature, Heart Rate, and behavioral response of newborn. And it has no significant effect on maintaining Spo2 level. However it can reduce the stress behavior of the newborn. Due to the limitations of the quality of studies included, multi-centered randomized controlled trial large sample size are needed in the future to evaluate the effects of prone position ventilation on neonatal respiratory distress syndrome.
柴苓汤治疗 2 例儿童支原体肺炎的观察
李玉林
经典中医研究    2019, 2 (1): 14-17.   https://doi.org/10.12032/CCMR20190104
Abstract PDF (1206KB)  
目的 : 使用小柴胡汤合上五苓散(柴苓汤)治疗支原体肺炎。方法 : 小柴胡汤和解少阳枢机,五苓散通调三焦水道,从水液输布代谢链治疗支原体肺炎。结果 :2 例支原体肺炎患儿使用柴苓汤后,体温恢复正常,肌体不适感消除。结论 : 柴苓汤治疗支原体引发的儿童高热、咳嗽、肺炎疗效确切,合方有效
Comparative efficacy of oral glucose solution versus non-nutritive sucking for pain relief in neonates during nociceptive procedures: a systematic review
Hui Liang, Xu Tian, Xiao-Ling Liu, Yi Dai, Jun Geng, Li Kang, Zhen Li, Li-Fen Jin
TMR Integrative Nursing    2018, 2 (3): 142-147.   https://doi.org/10.12032/TMRIN20180719
Abstract HTML PDF (640KB)  

Highlights:

This systematic review was performed to objectively investigate the analgesic effect of Oral glucose solution related to non-nutritive sucking in newborns during nociceptive procedures.

Editor’s Summary

Neonatal pain could cause several negatively psychological and physical consequences. To the date, non-pharmacological and pharmacological interventions have been two primary option for reducing pain.

Abstract

Background and aims: The comparative efficacy of glucose solution (GS) versus non-nutritive sucking (NNS) for pain relief in neonate remains controversial. This systematic review was consequently performed to objectively investigate the analgesic effect of Oral GS related to NNS in newborns during nociceptive procedures. Methods: All potential records were searched in PubMed, Web of Science, EMBASE, and the Cochrane Library to capture the randomized controlled trials comparing GS with NNS in terms of pain scores in neonates through January 2017. Two independent investigators screened the identified articles, extracted the data, and assessed the methodological quality of the included studies. All statistical analyses were completed by using Review Manager (RevMan) version 5.3.0.Results: Four studies, involving 248 neonates, were incorporated into these statistical analyses. For reducing pain scores, no statistical difference was detected when GS compared to NNS (4 trials; mean difference [MD], 0.75; 95% confidence interval [CI], -0.77 to 2.27; P = 0.33).Conclusion: Both the GS and NNS reduced the pain scores in neonates who undergoing Hepatitis B vaccination and venipuncture, but the NNS is more convenience than GS to some extent. Considered the limited evidences, more randomized controlled trials with high-quality, large-scale and appropriate measures time are warranted to further establish the comparative efficacy of these two options.

Efficacy and safety of the heated gel mattress for prevention of hypothermia in preterm infants during intra-hospital transport: a meta-analysis
Ya-Qian Liu, Meng-Jie Lei, Ting-Ting Liu, Yu-Feng Li, Chu-Yun Cui, Li-Jia Ni, Chang-De Jin
TMR Integrative Nursing    2018, 2 (3): 132-140.   https://doi.org/10.12032/TMRIN20180717
Abstract HTML PDF (658KB)  

Highlights:

This study evaluated the efficacy and safety of the heated gel mattress for prevention of heat loss on preterm infants with hypothermia during the transport systematically and objectively.

Editor’s Summary

Premature baby's hypothermia will cause short-term as well as long-term morbidities, including oxygen consumption, sepsis, early retinopathy and intraventricular hemorrhage. Therefore, implementation of early intervention strategies is vitally essential to prevent premature hypothermia.

Abstract

Objective: To evaluate the efficacy and safety of the heated gel mattress for prevention of heat loss on preterm infants with hypothermia during the transport systematically and objectively. Methods: Systematic searches on PubMed, EMBASE, Cochrane Library, Web of Science, CBM, CNKI, Wanfang and VIP were performed for randomized controlled trials (RCTs) or quasi-RCTs which explored the effects of heated gel mattress on prevention of hypothermia in premature infants relative to conventional alternatives. Studies were screened according to inclusion and exclusion criteria, extracted data and assessed quality. Then, meta-analysis and trial sequential analysis were performed by RevMan 5.3 and TSA v0.9 software developed at the Copenhagen Clinical Trials Center in Denmark, independently. Results: This systematic review included 10 studies which comprised 7 RCTs and 3 quasi-RCTs, encompassing 773 patients. The results of meta-analysis showed that in heated gel mattress group admission temperature on neonatal intensive care unit (SMD, 0.63; 95% CI, 0.40 to 0.87; P = 0.00), incidence of hypothermia (RR, 0.73; 95% CI, 0.57 to 0.93; P = 0.01) and hyperthermia (RR, 1.82; 95% CI, 1.31 to 2.54l P = 0.00) compared with the control group had significantly statistical difference; however, there was no significant difference in admission temperature on exothermic mattresses or TransWarmer mattress group, mortality, sepsis, retinopathy of prematurity, intraventricular hemorrhage III/IV between two groups. trial sequential analysis confirmed that the pooled results of admission temperature on neonatal intensive care unit and hyperthermia were stable and reliable; but the combination of low-temperature incidence and mortality indicators suggested that the sample size was insufficient. Conclusion: Heated gel mattress is a safe and effective rewarming intervention that can improve body temperature of hypothermic preterm infants during transport, reduce the incidence of hypothermia and does not increase the incidence of morbidity and complications. However, it is recommended that clinical monitoring of body temperature should be performed dynamically to decrease the potential risk of high fever. In addition, due to the limitation of quantity and quality of included studies, its cost-effectiveness and far-reaching influence on long-term follow-up outcomes need further evaluation through clinical multicenter, large sample, and high-quality research.

Fabry disease combined with acute interstitial nephritis : one case and literature review
Jinshan Sun
5TMR Clinical Research    2018, 1 (2): 61-67.   https://doi.org/10.12032/TMRClinicalRes201800017
Abstract PDF (564KB)  
Objective: To explore the clinical and pathological features of Fabry disease complication of acute interstitial nephritis. Methods: A retrospective analysis of a patient with Fabry disease and acute interstitial nephritis diagnosed and in the Department of Nephrology, Children’s Hospital Affiliated to Capital Institute of Pediatrics in January 2017 was performed. A literature search was performed with “Fabry disease, acute interstitial nephritis” as the keywords in Wanfang database and PubMeds database. Result: The patient was 10-years-old with acute renal dysfunction. Electron microscopy showed stratified myelin-like bodies, zebra bodies and fused foot segment. The patient was finally diagnosed with the combination of Fabry disease and acute interstitial nephritis. By now, such cases have been reported. Conclusion: Whether Fabry's disease and acute interstitial nephritis shared the common pathogenic mechanism is unclear. Early renal biopsy is important for the diagnosis of this disease.
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