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Dissecting the underlying pharmaceutical mechanism of Danggui Buxue decoction acting on idiopathic pulmonary fibrosis with network pharmacology
Cai-Ping Zhao, Hang Li, Xiao-Hong Liu, Shuang Liang, Xue-Lei Liu, Xin-Rong Li, Yi Luo, Mei-Ling Zhu
1Traditional Medicine Research
中医治疗肺神经内分泌癌 1 例体会
经典中医研究    2018, 1 (1): 18-22.
Abstract PDF (738KB)  
柴苓汤治疗 2 例儿童支原体肺炎的观察
经典中医研究    2019, 2 (1): 14-17.
Abstract PDF (1206KB)  
目的 : 使用小柴胡汤合上五苓散(柴苓汤)治疗支原体肺炎。方法 : 小柴胡汤和解少阳枢机,五苓散通调三焦水道,从水液输布代谢链治疗支原体肺炎。结果 :2 例支原体肺炎患儿使用柴苓汤后,体温恢复正常,肌体不适感消除。结论 : 柴苓汤治疗支原体引发的儿童高热、咳嗽、肺炎疗效确切,合方有效
Effects of interventions with mindfulness-breathing-stretching components on physiological and mental function of lung cancer patients: a mata-analysis
Meng-Jie Lei, Ting-Ting Liu, Ya-Qian Liu, Hui-Ping Wang, Yan-Qiu Huang, Chang-De Ji
3TMR Integrative Nursing    2019, 3 (5): 151-158.
Abstract HTML PDF (631KB)  


This review introduced the effect of mindfulness-breathing-stretching interventions on the physiological and psychological aspects of lung cancer patients. And the meta-analyses were executed to clarify the effect of mindfulness-breathing-stretching interventions in lung cancer patients.

Editor’s summary

Lung cancer was the main cause of cancer-related death in the world, which will cause several psychological issues. However, how to address it is still challenge. It is exciting that the findings from this study will promote the application of mindfulness-breathing-stretching intervention in lung cancer patients.


Objective: To systematically evaluate the effects of interventions with mindfulness-breathing-stretching components on lung neoplasms. Methods: Multiple electronic databases were used to search for research on the effects of interventions with mindfulness-breathing-stretching components on lung neoplasms. The randomized controlled trails and self-control trails were included. Electronic databases include: Cochrane library, Pub Med, EMBASE, Web of Science, China Biology Medicine disc (CBM), VIP, WANFANG and CNKI. Studies were selected according to certain inclusion and exclusion criteria, and data were analyzed by Rev Man 5.3. Results: 10 randomized controlled trials and 5 self-control trails were included. The results of meta-analysis were as follows: There was statistically significant difference between two groups in self-perceived burden, quality of life, sleep quality of patients and caregivers, medical coping modes and catecholamine; there was no statistically significant difference between two groups in psychological pressure, mental well-being, fatigue of patients and caregivers, cortisol, endorphins, immunological indexes and complement regulatory proteins. Conclusion: Compared with conventional treatment and nursing, interventions with mindfulness-breathing-stretching components can decrease improve the state of mind, quality of life, quality of sleep, medical coping style and some hormone indexes. However, because of the heterogeneity of indicators and inadequate included studies, larger sample size and high-quality studies are needed.

Feiji Recipe Reverses Lung Cancer Immune Escape by Inhibiting the Expression of IDO
Que Zu-Jun, Bi Ling, Zhou Zhi-Yi, Zhou Lei, Wang Qing, Luo Bin, Liu Jian-Wen, Li He-Gen, Tian Jian-Hui
Traditional Medicine Research    2016, 1 (3): 149-155.
Abstract HTML PDF (356KB)  

Tumor cells have developed multiple mechanisms to escape immune recognition mediated by T cells. Indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme inducing immune tolerance, is involved in tumor escape from host immune systems. Feiji Recipe, a Chinese herbal recipe that composed of 12 traditional Chinese medicines, has been used to recover immuno-surveillance and to interven immune escape in lung cancer patients. To elucidate the biological role of IDO in the tumorigenesis of lung cancer, and the intervention of Feiji Recipe on tumor immune escape, we established a mouse lung cancer cell line (2LL-EGFP-IDO) with overexpression of IDO. IDO expression did not affect cell proliferation. 2LL-EGFP-IDO cells were effective in reducing the level of tryptophan and increasing the level of its downstream metabolites, kynurenines, in culture medium as assessed by HPLC. Feiji Recipe could up-regulate the percentage of CD8+ T cells by inhibits the expression of IDO in co-culture system. The results of these studies indicate that Feiji Recipe can enhance the immune response and reverses tumor immune escape by induce the activity of CD8+ T cells, which might be related to the inhibition of IDO expression.

Gemcitabine and cisplatin combined with the Chinese herbal medicine compound Fuzhenggubenfang improve quality of life and progression-free survival in patients with advanced non-small cell lung cancer
Dong-Mei Jiang, Feng-Wei Wang, Li-Juan Zhang, Long Zhang, Tai Zhang, Wen-Hua Zhang
Traditional Medicine Research    2018, 3 (1): 40-51.
Abstract HTML PDF (518KB)  


Fuzhenggubenfang could be used as promising complementary medicine in chemotherapy for advanced NSCLC to improve quality of life and progression-free survival.

Editor’s Summary

Fuzhenggubenfang is the Chinese herbal medicine compound created on the basis of the addition and subtraction formula from Buzhongyiqi Soup, which was first recorded in Piweilun published in 1249 A.D. (Jin Dinasty of China).


Objective: To assess the role of chemotherapy combined with the compound Chinese herbal medicine, Fuzhenggubenfang (FZGBF), for treating advanced non-small-cell lung cancer. Methods: A total of 84 eligible patients were enrolled from October 2013 to July 2016. Patients were randomized to receive either chemotherapy alone as the control group or chemotherapy combined with FZGBF as the experimental group. The primary endpoint of the study was quality of life (QOL) and progression-free survival (PFS). Secondary endpoints were tumor response rate, toxicity, dropout rate, and univariate and multivariate analyses of clinicopathologic factors for QOL and PFS. Results: There was a significant improvement in QOL, including better overall health (P < 0.001), physical function (P < 0.001), role function (P < 0.001), emotional function (P < 0.001), cognitive function (P < 0.001), and social function (P = 0.031). Less fatigue, nausea or vomiting, insomnia, appetite loss, constipation, and alopecia were noted (All P < 0.001) when FZGBF was combined with chemotherapy in comparison to chemotherapy alone. The experimental group had a better PFS compared with the control group (P = 0.032). There was no significant difference in tumor response rate. FZGBF significantly reduced chemotherapy-induced anemia (P < 0.001), neutropenia (P = 0.023), nausea and vomiting (P < 0.001). The use of Chinese herbal compounds had only mild side effects. In this study, factors influencing QOL were the use of the Chinese herbal compounds (P < 0.001), performance status score (P = 0.027), clinical staging of cancer (P = 0.009), and sex (P = 0.044). Use of traditional Chinese medicine (P = 0.043) and the number of previous chemotherapy sessions (P = 0.003) were the factors influencing PFS in this study. Conclusion: FZGBF could improve QOL, compliance to treatment, relieved chemotherapy-related toxicities of patients, and consequently improved PFS, which is a promising drug combination in complementary medicine for the treatment of advanced NSCLC.

External application of Chinese medicine formula combined with analgesic drugs to treat lung squamous cell carcinoma pain: A case study with mixed methods
Chen Hong, Zhao Jun-Qiang, Jiao Yun-Lan, Wang Dou, Hao Yu-Fang
TMR Modern Herbal Medicine    2018, 1 (1): 29-34.
Abstract HTML PDF (212KB)  

Objective: To investigate the effectiveness of the external application of Chinese medicine combined with analgesic drugs to treat lung squamous cell carcinoma pain. Methods: A 54-year-old patient with upper lobe of the left lung squamous cell carcinoma was studied, who suffered from severe cancer pain with the initial numeric rating scale (NRS) 7 point when admitted. Exterior-use formula was applied to pain spot to relieve the pain. Mixed methods approach comprising NRS, Short-form of McGill Pain Questionnaire,quality of life scale, times of breakout pain, records of adverse reactions and semi-structured interviews were utilized to evaluate the effect.Results: With the combination use of the formula and analgesic drugs, the patient’s NRS score dropped from 7 to 3 point. Quality of life scale score improved from 33 to 42 point. Times of breakout pain reduced from twice to none. The amount of oxycodone decreased from 30 mg Bid to 10 mg Bid. No adverse effect appeared. The patient’s felt more energetic with good sleep and appetite. Conclusion: This formula is effective and safe for pain relief when combined with analgesic drugs, and may be a good option in dealing with local cancer pain. Future randomized, controlled studies are needed to better evaluate the efficacy.


When treating cancer pain, analgesic drugs can induce adverse reaction, such as nausea and peptic ulcer. Chinese medicine provides diversified approaches to remit cancer pain. Combining analgesic drug with external Chinese medicine can reduce the dosage of analgesic drug and improve the efficacy. The present study introduceda combination of analgesic drug and external application formula consisting of Chinese medicine torelieve the lung squamous cell carcinoma pain.

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer: a meta-analysis
Qiang Zhang, Yi-Huan Fan, Teng Zhang, Xiao-Lan Qin, Ji-Fang Song
TMR Integrative Medicine    2017, 1 (2): 68-78.
Abstract PDF (547KB)  
Objective: To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin (GP) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: we performed a systematic search in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database, Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database and Wanfang Database up to 30 January 2017. Randomized controlled trials (RCT) of Shenqi Fuzheng Injection combined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs were conducted on methodological quality assessment. Data extraction and data analysis were according to standards of Cochrane systematic review. Results: Eight trials were included including a total of 701 patients. Meta-analysis results: Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functional status of patients with NSCLC (OR = 3.44, 95% CI [2.26, 5.25], P < 0.0001) and clinical treatment efficacy (OR = (OR = 0.31, 95%CI [0.20, 0.47], P < 0.0001. The rate of leukopenia (OR = .31, 95%CI [0.20,0.47], P < 0.0001), thrombocytopenia (OR = 0.58, 95%CI [0.37, 0.91], P = 0.020), hemoglobin decline ((OR = 0.31, 95%CI [0.16, 0.59], P = 0.0004) and incidence of gastrointestinal reactions (OR = 0.58,P < 0.05) could be reduced. Conclusion: Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtained significantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-quality research to further prove.
Clinical efficacy of oral enteral nutrition in lung cancer patients receiving chemotherapy and/or radiotherapy: a systematic review of randomized controlled trials
Lang Huang, Jian-Guo Zhou, Wen-Xiu Yao, Yu Zhang, Fei Wang, Yi Wang, Shui-Ping Lv, Hu Ma
2TMR Integrative Medicine    2017, 1 (1): 20-29.
Abstract PDF (688KB)  

Background and Objectives: the effects of oral enteral nutrition (EN) in lung cancer patients receiving chemotherapy and/or radiotherapy were controversial, so we made a systematic review to analyze the clinical efficacy of EN in lung cancer patients after chemotherapy and/or radiotherapy. Methods and Study Design: Pertinent studies were identified by searching in PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), WanFang Database, China Biomedical Literature database (CBM) and Chinese Science and Technology Periodical Database (VIP). Energy intake, protein intake, weight and other data were extracted. Results: Finally, 5 randomized controlled trials (RCTs) were included in this systematic review. Patients in 3 studies received chemotherapy, in 1 with radiotherapy and in 1 with chemo-radiotherapy. The combined results showed that EN significantly increased energy and protein intake in lung cancer during chemotherapy, while there was no significant effect on other results after patients had received chemotherapy and/or radiotherapy. Conclusions: Limited evidence is available to judge whether EN can improve clinical effect of lung cancer with or without chemotherapy and/or radiotherapy, as clinical heterogeneity and other potential variation existed in this review. Further studies are needed.

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