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Research progress of Yinchenhao Decoction in the treatment of non-alcoholic fatty liver disease
Xiao-Ting Ma, Jing-Na Zhou, Shou-Jing Sheng, Shao-Qin Ge
7Drug Combination Therapy    2019, 1 (4): 237-244.   https://doi.org/10.12032/DCT201904004
Abstract PDF (302KB)  
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Non-alcoholic steatohepatitis (NASH) is the most serious type and a turning point in the progression of NAFLD. If not treated actively, NASH will progress to irreversible liver damage such as cirrhosis and hepatocellular carcinoma. At present, there are no specific therapeutic drugs in western medicine. The treatment methods are mainly to improve lifestyle and exercise therapy, to alleviate the symptoms of discomfort, delay the progress of the disease, and improve the quality of life. However, the effect is often not ideal, prone to recurrence, and compliance is relatively poor. Dramatically, traditional Chinese medicine has certain advantages in the treatment of NAFLD. Modern research has confirmed that Yinchenhao Decoction has a good effect on liver-protective and choleretic action and improving liver function. It has significant curative effect on various liver and gallbladder diseases such as acute liver injury and alcoholic liver disease. This article summarized the clinical and basic research of Yinchenhao Decoction in the treatment of NAFLD. We found that Yinchenhao Decoction can enhance the efficiency of NAFLD and improve symptoms such as dizziness, liver pain, hepatosplenomegaly and indigestion. The mechanisms may be related to that Yinchenhao decoction improves the disorder of glucose and lipid metabolism, inflammatory state and liver function.
《吴门验方》滋生流气饮治疗慢性胃炎伴肠上皮化生验案一则
刘叶, 欧阳钦
经典中医研究    2019, 2 (3): 49-52.   https://doi.org/10.12032/CCMR20190302
Abstract PDF (744KB)  
滋生流气饮出自《吴门验方》,系由吴雄志教授在柴芍六君子汤合逍遥散的基础上加减变化而成,临床上常用来治疗萎缩性胃炎、肠上皮化生、不典型增生、胃癌等器质性疾病,笔者导师临床亦多以此方治疗上述疾病,临证效验,现撷取验案一则以飨同道。

A Meta-analysis of the efficacy and safety of Kanglaite injection combined with chemotherapy in the treatment of pancreatic cancer
Lu Zhang, Jia-Jian Lv, Zhe Yang, Shu-Zhen Wu, Jun-Chen Feng, Xin-Juan Wang, Ya-Nan Liu, Xiao-Chun Han
7Drug Combination Therapy    2019, 1 (4): 210-223.   https://doi.org/10.12032/DCT201903005
Abstract PDF (761KB)  

Objective: To investigate the efficacy and safety of Kanglaite injection (KLT) combined with chemotherapy in the treatment of pancreatic cancer. Methods: PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Data, and  Chinese Biomedical Database (CBM) were searched to get the studies about KLT plus chemotherapy for pancreatic cancer  (from established to May 2019). Data extraction and bias risk assessment were carried out by two authors independently according to the retrieval method. RevMan (version 5.3) were employed for data analysis. Results: A total of 151 literatures were retrieved and 11 literatures were finally included. A total of 614 patients were included, including 308 in the treatment group and 306 in the control group. The results of meta-analysis showed that compared with chemotherapy alone, KLT combined with chemotherapy could improve the effective rate [PORR = 0.0009, OR=1.96, 95% CI (1.32, 2.92)] and disease control rate [PDCR <0.00001, OR=2.53, 95% CI (1.76, 3.62)], improve KPS score [P<0.00001, OR=3.59, 95% CI (2.00, 6.44)] and body mass indexes [P=0.0003, OR=3.45, 95% CI (1.78, 6.69)], prolong progression free survival (PFS) and overall survival (OS), reduce the rate of myelosuppression [P=0.03, OR=0.54, 95% CI (0.30, 0.95)], but could not reduce the occurrence of neurotoxicity [P=0.49, OR=0.80, 95% CI (0.42, 1.51)] and digestive tract reaction [P=0.51, OR=0.83, 95% CI (0.48, 1.44)]. Conclusion: KLT combined with chemotherapy can improve the curative effect of pancreatic cancer, improve the quality of life of patients, prolong the survival of patients, and reduce the incidence of bone marrow suppression. However, due to the limitation of the quality and quantity of included literatures, this conclusion needs to be verified by high-quality study.

A network pharmacological study on the potential mechanism of Yinchenhao Decoction in treatment of chronic hepatitis B
Jin-Yu Zhang, Xian-Fa Cai
7Drug Combination Therapy    2019, 1 (3): 134-152.   https://doi.org/10.12032/DCT201904002
Abstract PDF (1206KB)  

Background: Yinchenhao Decoction (YCHD), an ancient Chinese herbal medicinal compound prescribe for the treatment of jaundice, which long-term clinical experience and randomized trials have shown was effective against chronic hepatitis B (CHB). However, its mechanism remained unknown. With the gradual separation of pharmacodynamic components in YCHD and the development of computer virtual technology, network pharmacology provides an opportunity. Our study is to explore the underlying mechanism of YCHD for the treatment of CHB. Methods: The active compounds of YCHD were screened from TCMSP database, whose targets were predicted based on the ligands structures and the targets of CHB was selected from the TTD, DisGeNET, and Drugbank databases to obtain the potential targets of YCHD for CHB treating. Cytoscape 3.6.1 was applied for network analysis to identify key targets, and gene enrichment of the targets shared by both YCHD and CHB was performed by DAVID database. The virtual verification of binding activities between the target protein and the small molecule was finally performed by the Sytems Dock platform. Results: The potentially important targets associated with CHB corresponding to 33 compound components from YCHD included ESR1, CYP1A2, PTGS2, CYP1A1, ABCG2, MMP9. Besides, enriched were the related 8 KEGG pathways (P<0.05) such as ABC transporters, Bile secretion, TNF signaling pathway. Conclusions: This study used network pharmacology method to reveal the characteristics, “multi-component and multi-target and multi-pathway”, of YCHD on CHB treatment, providing thoughts for further research.

Study on multi-target mechanism of Radix et Rhizoma Rhei (Dahuang) and Semen Persicae (Taoren) on adhesion intestinal obstruction based on network pharmacology
Yin-Zi Yue, Li Zeng, Xiao-Peng Wang, Yang Zong, Shuai Yan
1Traditional Medicine Research    2019, 4 (4): 195-204.   https://doi.org/10.12032/TMR20190526121
Abstract HTML PDF (2208KB)  

Highlights

This study demonstrated that mechanism of Radix et Rhizoma Rhei (Dahuang) and Semen Persicae (Taoren) drug pair in the treatment of adhesion intestinal obstruction may be related to activate immune effect, decrease the expression levels of inflammatory cytokines, accelerate apoptosis of intestinal macrophages/T lymphocytes, and antagonize inflammatory reaction and tissue fibrosis to repair the intestinal mucosal barrier.

Traditionality

Radix et Rhizoma Rhei (Dahuang) (RERR) and Semen Persicae (Taoren) (SP) are the core drug pair commonly used in the treatment of adhesion intestinal obstruction. RERR and SP drug pair comes from the classical prescriptions of Chinese medicine including Didang soup and Taohe Chengqi decoction in Shanghanlun (an ancient book of Chinese medicine published in the 3rd Century A.D.) and Biejia Jian pills, Dahuang Shuchong pill, and Dahuang Mudan decoction in Jingui Yaolue (an ancient book of Chinese medicine published in the 3rd Century A.D.).

Abstract

Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang) (RERR) and Semen Persicae (Taoren) (SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of RERR and SP were filtered based on the traditional Chinese medicine system pharmacology analysis platform. Cytoscape 3.2.1 was applied to build the ingredient-target network of RERR and SP for AIO. Results: Fifteen active components were predicted from the RERR and SP herb pair, such as aloe-emodin, catechin, rhein, gibberellin (GA) 119, GA120 and GA121. These components were applied to 59 targets mainly involved in many biological processes such as signal transduction, anti-apoptosis, and inflammatory response involved in activating the immune effect. Conclusion: This study proposes the system pharmacology method and identifies the potent combination therapeutic mechanism of RERR and SP for AIO. This strategy will provide a new insight to the study of herb combinations.

Effects of Da-Cheng-Qi decoction on enteroparalysis and serum inflammatory cytokines in patients with severe acute pancreatitis
Xiao Wang, Guo-Hong Yang, Chen-Xiao Wang, Chun-Ying Li, Min Guo, Ming-Hao Liu, Zhen-Jun Zeng, Jun Ma, Qin-Sheng Zhang
1Traditional Medicine Research    2019, 4 (4): 205-212.   https://doi.org/10.12032/TMR20190508119
Abstract HTML PDF (1083KB)  

Highlights

This study demonstrated that Chinese herbal formula Da-Cheng-Qi decoction combined with the conventional treatment could effectively decrease the serum levels of CCL2, CRP, and IL-8, relieve enteroparalysis, and shorten the duration of hospitalization in patients with severe acute pancreatitis

Traditionality

Da-Cheng-Qi decoction (DCQD) is a famous Chinese herbal formula that includes Radix et Rhizoma Rhei (Dahuang), Cortex Magnoliae Officinalis (Houpu), Fructus Aurantii Immaturus (Zhishi), and Natrii Sulfas (Mangxiao). The original record about DCQD can be traced back to the 3rd Century A.D. According to the description in Shanghan Lun, an ancient book of Chinese medicine published in Han Dynasty of China, DCQD had the effect of purging accumulation and clearing heat from the stomach and intestine.

Abstract

Objective: The objective of this study was to investigate the effects of Da-Cheng-Qi decoction (DCQD) on enteroparalysis and levels of the serum inflammatory cytokines C-C motif chemokine ligand 2 (CCL2) and interleukin-8 (IL-8) in patients with severe acute pancreatitis (SAP). Methods: A total of 48 patients diagnosed with SAP who hospitalized in First Affiliated Hospital of Henan Traditional Chinese Medicine University from May 1, 2016 to May 30, 2018 were randomly assigned to the control or treatment groups. Patients in the control group (n = 22) received conventional treatment and those in the treatment group (n = 26) received conventional treatment as well as additional DCQD for 10 days. The duration of abdominal pain and distension, the time when bowel sounds returned to normal, changes in the levels of serum amylase, lipase, C-reactive protein (CRP), CCL2 and IL-8, as well as acute physiology and chronic health evaluation (APACHE) II scores of patients on days 1 and 10 were recorded and compared. Results: The duration of abdominal pain and distension, the time when bowel sounds returned to normal, the levels of blood amylase, lipase and CRP, and APACHE II scores of patients in the treatment group decreased significantly compared with those of patients in the control group. Though there were no statistical differences in serum CCL2 and IL-8 concentrations on day 1 between patients in these two groups, the levels of serum CCL2 and IL-8 in the treatment group were lower than those in the control group on day 10. Conclusion: DCQD may decrease the levels of CCL2, CRP, and IL-8 in patients with SAP, quickly relieve enteroparalysis, and shorten hospitalization duration.

Application of herbal rectal suppositories beyond intestinal disorders in Persian medicine
Fatemeh Ebrahimi, Mohammadali Torbati, Zoleikha Khoshbakht, Laleh Khodaie
1Traditional Medicine Research    2019, 4 (3): 160-172.   https://doi.org/10.12032/TMR20190414115
Abstract HTML PDF (555KB)  

Highlights

This review provides a new insights of the application of herbal rectal suppositories beyond anorectic and intestinal disorders in traditional Persian medicine, such as sciatic, lower back pain and joint aches, fever and ascites.

Traditionality

The first application of rectal suppositories was recorded in Egyptian civilization (3150 B.C.). Other literatres in traditional Chinese, Persian, and Ayurveda medicines showed its prevalence as a dosage form.

Abstract

Background: Herbal rectal suppositories (RSs) were prescribed not only as a drug delivery system but also as a storing method in Persian medicine. According to the record of ancient references, RSs were clinically administered for diarrhea, constipation, colitis, ascites, dysentery and intestinal parasites, sciatic, lower back pain and joint aches, fever, kidney disease and as an aphrodisiac. Objectives: The aim of this study is to categorize and review different types of RSs, their main herbal components and to find evidence to elucidate their clinical administration. Results: In this study, 7 manuscripts were studied to extract and categorize 11 types of herbal rectal suppositorie (RS) formulations, their ingredients and therapeutic indications. Furthermore, the Persian and scientific names of 43 herbs and their temperaments were mentioned in this study. Hence, ancient therapeutic indications of herbs used in RS formulations as well as their proven effects have been studied, which makes it possible to compare ancient and proven indications of medicinal plants used as ingredients of RSs. Conclusions: In modern medicine, RSs are mostly used for anorectic disorders. However in traditional Persian medicine, they were commonly used not only for anorectic and intestinal diseases, but also as an aphrodisiac, an agent for healing joint, sciatic pain and lumbago, an anti-fever, and an anti-ascites. Other implications of this study could be producing new insights of utilizing herbal RSs in diseases and disorders beyond anorectic and intestinal disorders.

Digestion process and causes of indigestion based on Avicenna's view and modern medicine
Ali Reza Derakhshan, Mahdi Yousefi, Sohrab Dehghan, Arman Zargaran, Mahmood Khodadoost
1Traditional Medicine Research    2019, 4 (3): 140-147.   https://doi.org/10.12032/TMR20190225100
Abstract HTML PDF (371KB)  

Highlights

This manuscript reviews digestion process and the problem of indigestion from the perspective of Avicenna and aims to establish a link between the perspective of Avicenna and the evidence of modern medicine.

Traditionality

Avicenna (born 980, died 1037, Hamadan, Iran) is regarded as the most distinguished Persian medical scholar. His masterwork Canon of Medicine became the mainstream medical system in the west until 17th century. Avicenna paid a lot of attention to gastrointestinal disorders and his view was based on the humoral theory.

Abstract

The process of food digestion is one of the most important physiologic processes in human body. In this review, we are seeking the views of Avicenna, the most distinguished Persian medical scholar about digestion and indigestion. Avicenna’s view was based on the humoral theory. Avicenna has focused scrutiny on the process of digestion. He divided this process into four phases including gastric, hepatic, intravascular and intra-organ digestion. A defect in any of these phases can lead to disturbance in other stages. Avicenna approached the problem of indigestion through factors of diet, lifestyle and inherent structural characteristics of digestive organs. Modern medicine confirms Avicenna's opinion about the start of digestion from the mouth, the role of the stomach in digestion and the role of the liver in the metabolism of foods. Overeating or eating certain foods, snacking between meals, eating variety of different foods together, intense physical activity, sexual activity after a meal, stress and sleep insufficiency are among factors that may be linked to indigestion in modern medicine viewpoints and also have been mentioned in Avicenna's teachings. It seems rational to consider the medical approaches recommended by Avicenna for future studies in the field of digestive disorders.

Progress of Bai He Di Huang decoction on intestinal flora of mouse with depression
Dong-Xue Chen, Cun-Xia Ren, Ya-Wen Bai, Bao-Shan Rong, Xin Ding, Chang-Qing Li, Hui-Min Zhao, Zhan-Hong Qian
8Food Therapy and Health Care    2019, 1 (2): 30-34.   https://doi.org/10.12032/FTHC201905001
Abstract PDF (1480KB)  
Depression is a recurrent, common, and potentially life-threatening psychiatric disease. Intestinal flora is a large number of microbial communities that are parasitic in the human digestive tract. Current evidence suggests that the occurrence of depression may be related to intestinal flora. Long time ago, Bai He Di Huang decoction was used to treat the depression. Recently, researchers found that Bai He Di Huang decoction could affect the the intestinal flora of patients with depression. This review focuses on the clinical progress of Bai He Di Huang decoction in the treatment of depression, and explores the effect and mechanism of Bai He Di Huang decoction on the intestinal flora of depressive mouse.
Intestinal microflora in patients with liver disease
Man-Man Wu, Hai-Ning Yu, Sheng-Rong Shen
8Food Therapy and Health Care    2019, 1 (2): 56-62.   https://doi.org/10.12032/FTHC201905005
Abstract PDF (1787KB)  
Intestinal microflora is closely related to the occurrence and development of liver diseases. The imbalance of intestinal microflora can cause the increase of endotoxin and change the metabolic pathways such as lipid metabolism, thus causing the occurrence of liver diseases. It is beneficial to explore the effects of intestinal microflora on metabolism and its relationship with liver disease, which maybe reveal the pathogenesis of liver disease and find new therapeutic targets for liver disease. This paper reviewed the effects of intestinal microflora on endotoxin, short-chain fatty acid metabolism, fatty acid metabolism, bile acid metabolism, choline metabolism and endogenous alcohol production, and analyzed the relationship between intestinal microflora and liver disease.
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