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Bibliometrics and social network analysis of clinical researches on acupuncture and moxibustion
Jin-Hua Si , Chen Zhao, Yan Li, Ge Li, Jin-Hui Tian, Hong-Cai Shang
92Medical Data Mining    2018, 1 (2): 46-56.
Abstract PDF (771KB)  
Objective: In order to explore the development trend and research hotspots of clinical researches of acupuncture and moxibustion and provide some insight into the key research direction for researchers. Methods: The clinical studies of acupuncture and moxibustion were searched in PubMed. Using the method of bibliometry, the year, country, journals, authors were analyzed. The cluster analysis was used to analyze subject terms by the social network analysis. Results: A total of 4237 literature were retrieved, published in 617 journals. The number of clinical studies on acupuncture and moxibustion has been increased substantially since 2006. The clinical researches on acupuncture and moxibustion have been conducted worldwide, specifically in China, the United States, Britain, Sweden, etc. Three major author cooperation networks (China, South Korea and European and North American countries) has been formed. The cluster analysis based on 53 high-frequency theme words indicates that
the clinical researches on acupuncture and moxibustion are mainly concerned about acupoint selection associated with pain, stroke, knee osteoarthritis and other diseases in different age groups, blind, treatment outcomes, time factor of acupuncture, etc. Conclusion: Clinical researches on acupuncture and moxibustion have been widely concerned by international medicine. The research direction is clear, Thematic is concentrate, and research paradigm has been formed. However, international influence is still limited academically. The cooperation between different authors or teams is insufficient. The core research hotspots include the selection of acupoint, acupuncture and moxibustion tools, research design, treatment outcome, blind, time factor, follow-up, placebo, clinical protocol, quality of life, patient satisfaction and so on. 
A review of acupuncture and moxibustion in treating children with cerebral palsy sitting disorder
Chaoxi Zhu, Fanrong Liang
90Life Research    2018, 1 (1): 18-22.
Abstract HTML PDF (2892KB)  

Cerebral palsy is one of the important factors in children's disability. Patients’ seat dysfunction has a serious impact on their daily life and their family. However, there is currently no effective treatment for the cerebral palsy seat dysfunction. So, it is of importance to search a new way to make a breakthrough. Acupuncture has significant advantages in the treatment of functional disorders. In this paper, the literature about clinical research of acupuncture treatment of cerebral palsy seat dysfunction are summarized. We have carried on the mechanism analysis of sports medicine respectively from three angles, including traditional Chinese medicine, western medicine and traditional Chinese and western medicine combined with sports medicine. We conclude that acupuncturing acupoints on Du meridian, Beishu points and Jiaji points has significant effect on the function of sitting unable children with cerebral palsy, such as strengthening the spleen, tonifying the kidney and promoting Yangqi and stimulating the sensory nerve and so on. Acupuncturing points for the treatment of cerebral palsy provides a lot of inspiration for human physiology research in the future and clinical treatment of neurological diseases.

Evaluating the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis combined with infertility
Hua Wang, Yan Chen, Yong Yin, Chun-Hua Cao, Sai-Li Wang, Qin Wang, De-Xi Peng, Chun-Jian Zhu, Lin-Wei Chen
Traditional Medicine Research    2018, 3 (5): 243-250.
Abstract HTML PDF (334KB)  


Thunder-Fire moxibustion with ovulation monitoring significantly improved the pregnancy rate of patients diagnosed with adenomyosis- associated infertility.

Editor’s Summary

Thunder-Fire moxibustion stemmed from the Taoism magic arts before the Yuan Dynasty of China (1271 A.D.-1368 A.D.) and took shape in the middle of the Ming Dynasty of China (1368 A.D.-1644 A.D.).


This study evaluated the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring for the treatment of adenomyosis-associated infertility. A series of 120 patients diagnosed with uterine adenomyosis and infertility and cold coagulation blood stasis syndrome in traditional Chinese medicine (with the clinical manifestations of premenstrual or menstrual lower abdomen cold pain, pain reduction with heat application, and cold extremities) were randomized equally to treatment group with Thunder-Fire moxibustion and ovulation monitoring as well as control group with ovulation monitoring only. Treatment continued for six menstrual cycles. The pregnancy rate of the treatment group was significantly increased with the control group (50.0% vs. 23.3%, P = 0.021). Dysmenorrhea and the traditional Chinese medicine syndrome in the treatment group improved significantly compared with the control group (3.87 ± 2.03 vs. 5.70 ± 1.01, P = 0.002 and 7.33 ± 4.11 vs. 10.52 ± 2.33, P = 0.006, respectively), and there was also significant between-group differences in serum cancer antigen 125 (55.45 ± 14.65 vs. 63.34 ± 11.41, P = 0.031). However, the average uterus diameters in the treatment and control groups were not significantly different (67.13 ± 7.59 vs. 69.89 ± 5.30, P = 0.137). Thunder-Fire moxibustion with ovulation monitoring improved the pregnancy rate of patients diagnosed with adenomyosis-associated infertility.

Is Thunder-Fire moxibustion effective in the treatment of adenomyosis combined with infertility?
Xiong-Zhi Wu
1Traditional Medicine Research    2018, 3 (5): 214-214.
Abstract HTML PDF (136KB)  

Adenomyosis is defined as the presence of endometrial glands and stroma within the myometrium. It can seriously endanger a woman’s quality of life, causing infertility, dysmenorrhea, and chronic pelvic pain. The definitive treatment for adenomyosis is hysterectomy. However, this option does not benefit patients who wish to preserve their fertility [1]. Although medical treatments are effective in improving clinical symptoms, there are limited data to support medical effectiveness in improving the chances of pregnancy.

   Thunder-Fire moxibustion, a type of special moxibustion therapy, has significant efficacy in the treatment of pain and Yinzheng (a symptom of Chinese medicine, with the clinical characteristics of chills, cold limbs, loose stools or diarrhea, etc.). Thunder-Fire moxibustion may originated in the Taoist magic arts before the Yuan Dynasty (1271 A.D.–1368 A.D.) and matured in the middle of the Ming Dynasty (1368 A.D.–1644 A.D.) (Taoism is a Chinese native religion that arose in the Donghan Dynasty of China; magic arts constitute an extremely important part of the Taoist and aim to remain healthy) [2]. Today, Thunder-Fire moxibustion remains in use, and physicians have employed it to treat adenomyosis. The pathology of adenomyosis is considered cold stagnation and blood stasis. Its clinical characteristics sharing some similarity with those of Yinzheng of Chinese medicine. Thunder-Fire moxibustion warms and disperses cold evil, as well as activates blood circulation and relieves pain [3-7]. However, the underlying mechanism of Thunder-Fire moxibustion remains unknown and few articles touch on the level of modern medical mechanism. Penetration and transmission of the heating effect, infrared rays, pharmacochemical and physical factors, and different channels and acupoints produced by the burning moxa stick containing Chinese herbs may be responsible for its efficacy [8].

   Here, a clinical investigation into 120 cases evaluated the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis combined with infertility. Moxibustion at Guanyuan (CV4) and Qihai (CV6) points with Thunder-Fire moxibustion abdominal array could increase the pregnancy rate for patients with adenomyosis, as well as improve dysmenorrhea and related traditional Chinese medicine syndromes. To read more about Thunder-Fire moxibustion, see this article: Evaluating the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis combined with infertility. Link:

Moxibustion treatment for knee osteoarthritis: cumulative meta-analysis and trial sequential analysis
Jun-Chen Fan, Hui-Min Zhang, Miao Zhang, Fan-Mei Kong, Wen-Rui Wang, Yu-Ling Wang
TMR Integrative Nursing    2018, 2 (3): 115-122.
Abstract HTML PDF (1103KB)  


This article evaluated the effect of moxibustion on knee osteoarthritis patients with cumulative meta-analysis, and trial sequential analysis was applied to test the authenticity of results.

Editor’s summary:

Pain is a major problem in patients with knee Osteoarthritis. Moxibustion, a traditional non-invasive treatment in China, stimulates specific acupuncture points by the heat from the burning strips to alleviate symptoms, such as muscle strain, osteoarthritis, shoulder pain, neck and back pain.


Objective: To evaluate the effect of moxibustion on knee osteoarthritis patients with cumulative meta-analysis, and trial sequential analysis was applied to test the authenticity of results. Methods: We searched PubMed, EMbase, The Cochrane Library, CNKI and CBM to collect RCTs about moxibustion on knee osteoarthritis patients. The selection of literature, data extraction and evaluation of eligible literature were carried out independently by two reviewers. Then Stata11.0 software was used for data analysis. Result: Totally 11 RCTs involved 1005 patients were recruited. The results of meta-analysis showed that no significant differences were found between the two groups in VAS, moxibustion is better than drug therapy in effective rate [OR = 0.40, 95%CI (0.27, 0.60)] and knee score [SMD = -0.70, 95%CI (-1.22, -0.19)]. The result of trial sequential analysis indicated that the sample size didn’t reach the TSA Boundary on VAS, the sample size of effectiveness achieved Require Information Size. In the indicator of knee score has obtained certain result before reaching the Require Information Size. Conclusion: moxibustion is superior to drug therapy on treatment knee osteoarthritis. However, large sample size and high-quality studies are still needed.

Design and application of automatic constant temperature moxibustion box
Wei Xie, Yu Leng, Ping Li, Ping Liu, Hai-Bo Li, Hua-Qian Dong, Wan-Feng Yang
3TMR Integrative Nursing    2018, 2 (4): 160-164.
Abstract HTML PDF (878KB)  


Moxibustion was applied in clinical practice thousands of years ago. However, the application of this method is rather limited and easy hurt the patients with scald. This paper objectively analyzed the effects and safety of a novel automatic constant temperature moxibustion box in practice.

Editor’s summary

As the most common of traditional Chinese medicine techniques, moxibustion has been used to treat all kinds of conditions, for example chronic pain. It is noted that, however, it is not convenience to apply this method. Considering this, the authors listed in the present paper designed a novel automatic constant temperature moxibustion box, and found that this box is effective and safe to use in clinical practice.


Objective: To explore the clinical application effect of self-designed automatic constant temperature moxibustion box. Methods: From June 2016 to January 2017, 150 patients with neck, shoulder, back and leg pain admitted to our hospital were treated with moxibustion under the informed consent of the patients. The patients were randomly divided into control group and observation group, 75 cases each. The group used traditional moxibustion box for moxibustion treatment, and the observation group used automatic constant temperature moxibustion box for moxibustion treatment for 15 days. After the treatment, the patient's safety, comfort, satisfaction and adverse reactions were compared, and the results were analyzed using SPSS 20 statistical software. Results: The comfort and satisfaction in study group were all superior to that of control group, with statistically significant difference (P < 0.01). For patient's safety, the ratio of patients suffered from scald in study and control groups was 5.3 /100 and 0, respectively. Conclusions: It is of great significance for improving clinical efficacy and preventing medical risks. It is worthy of clinical application.

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