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Study on the mechanism of Coix seed in the treatment of colon cancer Based on network pharmacology
Jin-Lin Wu, Zhu Yang, Feng-Xi Long, Li Luo, Xun Liu, Jia Wang, Ting Yu, Dong-Xin Tang
8Food Therapy and Health Care    2019, 1 (4): 102-113.   https://doi.org/10.12032/FTHC201910001
Abstract PDF (3838KB)  
Objective: Study on the mechanism of Coix seed in the treatment of colon cancer based on network pharmacology. Methods: The main chemical components of Coix seed were identified by TCMP, and the target sites of drug components were screened. The target of the protein was mapped to the corresponding gene target through the Uniprot database. Genecards database was used to find the target gene of human colon cancer disease, and then the disease gene target was combined with the drug gene target to screen the common target of disease-drug composition, and the STRING platform was used to construct the drug component-disease target protein interaction. (PPI) network model. The Bioconductor database was used to analyze the potential targets, related molecular functions and signaling pathways of cocoon in the treatment of colon cancer by GO and KEGG enrichment. The disease-drug component-target-signal pathway network was established by Cytoscape software. Results: It was found that there are 9 pharmacodynamics and 28 targets related to colon cancer treatment, and GO functional enrichment analysis is based on correction. P<0.05 screened 346 molecular functional related items, including 256 biological processes, 48 molecular functions, and 42 cell components. KEGG functional enrichment analysis screened 24 related pathways according to the adjusted P<0.05. Conclusion: PTGS2, AR, ESR1, PGR, ADH1C, AKR1B1, LTA4H, NCOA1, NCOA2 and other related targets may be potential targets for the treatment of colon cancer.
Potential relevance of diet to breast cancer
Hui-Yang Lin, Xian Wang
8Food Therapy and Health Care    2019, 1 (4): 114-122.   https://doi.org/10.12032/FTHC201911002
Abstract PDF (934KB)  
Diet is thought to affect the occurrence and progression of breast cancer while the exact relationship between diet and breast cancer remains largely unclear. This review aims to elucidate the association of specific foods with breast cancer and potential underlying mechanisms. For example, sulforaphane is inversely related to the disease while the impacts of soy and meat on breast cancer are disputable. To some extent, soy is a protective factor while red and processed meat is an adverse one. Due to heterogeneity of breast cancer, menopausal and estrogen receptor statuses can influence the diet-cancer relation. In brief, it may be reasonable to recommend breast cancer patients to eat high soy foods and cruciferous vegetables and low red and processed meat.
The therapeutic mechanism of black soybean in atherosclerosis based on network pharmacology
Yi-Xin Jiang, Ming-Han Zhao, Qing-Feng Wang
8Food Therapy and Health Care    2019, 1 (4): 130-139.   https://doi.org/10.12032/FTHC201911004
Abstract PDF (6372KB)  
Objective: To investigate the cardiovascular mechanism of black soybean, the biological characteristics of black soybean were studied by bioinformatics, and the mechanism of its treatment for atherosclerosis was further determined. 
Methods: Firstly, the basic data sets of effective components and corresponding targets of black beans were constructed, and then mapped to the AS background network obtained from DisGeNET database and CTD database. Finally, the potential targets of black beans acting on AS were obtained. After constructing the protein-protein interaction (PPI) network, the topological characteristics of these targets were analyzed. KEGG and GO were enriched to obtain the potential mechanism of black soybean acting on AS. 
Results: There were 12 bioactive components reported in black soybean. Among them, beta-sitosterol, stigmasterol and N-(4-hydroxyphenylethyl) ACTINIDINE were the three most active components. There are 19 targets of black soybeans acting on PPI network of AS disease. Among them, ADRB2 and PTGS2 are important targets for black soybeans to alleviate AS. The therapeutic pathways include arachidonic acid metabolism and serotonin synapse. 
Conclusion: Black soybean can play a therapeutic role in AS through multi-target and multi-pathway. The application of network pharmacology can quickly clarify the characteristics of functional foods and identify their potential targets and mechanisms for disease treatment.
Methods of preparation of egg and therapeutic uses: a review perspective of Persian Medicine
Fatemeh Moradi, Malihe Tabarrai, Fatemeh Nejatbakhsh
8Food Therapy and Health Care    2020, 2 (1): 32-39.   https://doi.org/10.12032/FTHC202002004
Abstract PDF (301KB)  
Background: The nutrients in eggs play an important role in the health of different body organs like the brain, cardiometabolic system, musculoskeletal system, skin and eyes and so the eggs can be considered as functional foods. In order to maintain the highest nutrient content of an egg, it is recommended to cook it properly, but no specific clinical research has been carried out yet on the role that the cooking of an egg plays in its food and health properties. For this reason, this study has collected and discussed the topics related to a variety of methods of cooking eggs, based on the texts of Persian Medicine, and conducted a comparison with modern sources of nutrition. Methods: The present study is a review in which sources of Persian Medicine (PM) were searched in software JamiTib (Version 1.5) and Persian electronic banks, sites of PubMed, Google Scholar, ScienceDirect, and Embase and websites of health reference of American food and water. Finally, the results obtained were classified and a content analysis was carried out. Results: In the PM books, in addition to referring to the different properties of eggs, different effects of different egg preparation have been investigated. The wise men of the school of medicine have proposed at least five methods of egg preparation, including very soft boiled, soft-boiled, hard-boiled, fried, and omelet. In the texts, the healing properties of each case and the quality of digestion in the body were separately investigated. Among the five main methods of preparation eggs, the therapeutic and digestive effects of soft-boiled eggs are emphasized to a greater extent, because easy digestion leads to more beneficial effects of the yolk of the eggs. Conclusion: Though the wise men of Persian Medicine have proposed a variety of methods to cook eggs, ease of digestion is one of the most important factors in their decision-making while proposing the type of cooking method for therapeutic prescriptions. In contrast, in modern nutrition research, regardless of the method of cooking eggs, the effect of its use on diseases like heart disease or diabetes has been studied. Owing to the fact that many cases of eggs, as mentioned, have been confirmed in PM texts during modern scientific surveys, it appears that clinical studies on the relevant issues of eggs in this context are useful in better understanding therapeutic effects.
Predict the anti-cancer mechanism of astragalus membranaceus based on network pharmacology
Jia Wang, Zhu Yang, Feng-Xi Long, Jin-Lin Wu, Ting Yu, Dong-Xin Tang
8Food Therapy and Health Care    2019, 1 (3): 63-72.   https://doi.org/10.12032/FTHC201908001
Abstract PDF (3834KB)  
Objective: To explore the anti-cancer mechanism of active ingredients of Astragalus membranaceus(AM) through network pharmacology. Methods: TCMSP, PubChem, STICTH and GeneCards databases were used to predict and screen the main active ingredients and anti-cancer targets of AM. Active ingredient-target-disease network was constructed by Cytoscape 3.7.0 software, and protein interaction network was constructed by STRING platform. KEGG signaling pathway and GO biological process of targets were analyzed by Bioconductor database. Results: Twenty-four active ingredients were screened from AM, which acted on 106 cancer targets such as PTGS, NCOA2, ADRB2, PRSS1, NOS2, NOS3, GABRA1. Through these targets, the anti-cancer effect of AM mainly acts on small cell lung cancer, colorectal cancer, thyroid cancer, breast cancer, non-small cell lung cancer, hepatocellular carcinoma, pancreatic cancer, gastric cancer, endometrial cancer, enriched in chemical carcinogenesis, Platinum drug resistance, Epstein-Barr virus infection, TNF signaling pathway, Toll-like receptor signaling pathway, p53 signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, and PI3K - Akt signaling pathway. Conclusion: This study found that the main anti-cancer compounds of AM are kaempferol, quercetin, 7-O-methylisomucronulatol, formononetin, isorhamnetin, Calycosin, 3,9-di-O-methylnissolin. The main targets include PTGS, PTGS1, NCOA2, ADRB2, PRSS1, NOS2, NOS3, GABRA1, F2. The mechanisms involved in anticancer could be summarized as following: blocking the chemical carcinogenesis, reversing the platinum drug resistance, anti - Epstein - Barrvirus infection, and inhibiting cell proliferation related signaling pathways, such as TNF signaling pathway, Toll-like receptor signaling pathway, p53 signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, PI3K - AKT signaling pathway.
Research on hypertension in hohhot of mongolian: analysis of 9675 cases survey data
Hong-Mei Yu, Jian-Qiang Wu
8Food Therapy and Health Care    2019, 1 (3): 73-77.   https://doi.org/10.12032/FTHC201908002
Abstract PDF (791KB)  
Objective: Through investigating the daily habits of hypertensive and non-hypertensive Mongolian in Hohhot to explore the effect of daily habits on hypertension and further provide basis for future policy making. Methods: Two community health service centers were identified in each of the four districts of Hohhot City using a stratified cluster random sampling method and a multi-stage stratified sampling method. Results: By January 2019, a total of 9,800 people was investigated, and 9675 people with complete data. The effective rate of the questionnaire was 98.7%. The standardized prevalence of hypertension was 21.8% in Mongolia. The prevalence rate of hypertension in Mongolia was statistically significant among the different genders, ages, presence or absence of obesity, different diet types, whether smoking or drinking, or having tea, and aerobic exercise. (P < 0.05 for all). Multivariate unconditional logistic regression analysis showed that males were risk factors for hypertension; female, non-obese, non-hobby meat, no smoking, hobby tea, no alcohol and aerobic exercise were protective factors. Obesity, hobbies, meat, smoking, drinking are important risk factors for hypertension in Mongolian population in Hohhot. Conclusion: It is preliminarily clarified that the risk factors related to hypertension are mainly related to their own health-related behaviors and genetic factors, suggesting the necessity of healthy physical examination, maintaining blood pressure stability, controlling body mass, and moderate exercise.
The progress of nutritional support for chronic obstructive pulmonary disease
Jiao-Jiao Wang, Mei Tang, Yun-Xian Ma, Peng-Cheng Zhou
8Food Therapy and Health Care    2019, 1 (3): 89-96.   https://doi.org/10.12032/FTHC201908004
Abstract PDF (1026KB)  
The patients with chronic obstructive pulmonary disease (COPD) often occur weight loss and reduced muscle mass, which leads to decreased exercise capacity and vital capacity. The nutritional status is closely related to the prognosis of patients with COPD and nutritional support has played an important role in the treatment of COPD. In order to provide proper nutritional support, this article reviews the progress of nutritional support in COPD from the causes of malnutrition, energy demand assessment, assessment of nutritional risk and nutritional support methods. Moreover, this review specially reviewed the application of traditional Chinese medicine diet.
Mining potential adverse drug reactions of Houttuynia cordata Thunb from "real world" cases.
Wei-Xiu Fan, Li-Ting Yu, Li-Ping Yang
8Food Therapy and Health Care    2019, 1 (3): 78-88.   https://doi.org/10.12032/FTHC201908003
Abstract PDF (912KB)  
Objective: Search the "real world" case reports of Houttuynia cordata Thunb (HCT)-associated adverse drug reactions (ADRs) to systematically mine potential ADRs of HCT and further investigate whether HCT contained preparations could cause aristolochic acid nephropathy or cancer. Methods: PubMed, EMBASE, Science Direct, Scopus, Web of Science, and CNKI, Wanfang, VIP, Sinomed databases were searched from databases setup to 1st January 2019. All case reports using HCT contained preparations were pooled according to inclusion and exclusion criteria. 15 items in case reportes including basic informations of studies/patients, characters/treaments of ADRs were extracted and analyzed. Results: A total of 346 case reports (441 patients) on the use of different preparations of HCT were finally pooled, among which 89 articles (117 patients) just presented efficacy reports without ADRs and 257 articles (324 patients) on the HCT-related ADRs were further analyzed. ① HCT in vivo injections were recorded in 265 articles (338 patients) including 249 ADR reports (315 patients) and 16 efficacy reports (23 patients). As for the ADRs reports, allergic reaction was the major ADRs with different symptoms and onset time. The worst consequences were anaphylactic shock (116/315) and death (11/315), followed by dyspnea (228/315), change of complexion (181/315), heart of abnormality (180/315), chest tightness (147/315), cyanosis (142/315) and so on. The fast onset time was 10 seconds and the most ADRs happened in 30 minutes. Dexamethasone was the mainly medication to treat ADRs. ② Oral HCT agents were descripted in 75 articles (94 patients) including 8 ADR reports (9 patients) and 67 efficacy reports (85 patients). Among the 8 ADR reports, 8 patients used Chinese patent medications contained HCT and only 1 patient used HCT decoction. The ADRs almost manifested as skin symptoms, including rubella, macula, rash and urticaria.③HCT external preparations reported in 6 articles (9 patients), none of those presented any ADRs symptoms. ④ No case was found to develop cancer, aristolochic acid nephropathy, interstitial nephritis, renal interstitial fibrosis or renal failure due to HCT preparations. Conclusion: The HCT-related ADRs were mostly caused by its processed preparations, including HCT injections and patent preparation. The oral HCT agents as docoction rearly caused ADRs. There were no reports of aristolochic acid nephropathy or cancer cases caused by HCT.
Research Progress in Arecoline-induced Oral Submucous Fibrosis
Jing-Wen Jiang, Xue-Wu Chen, Qing-Hua Yao, Hui Zhan
8Food Therapy and Health Care    2019, 1 (3): 97-101.   https://doi.org/10.12032/FTHC201908005
Abstract PDF (1756KB)  
Areca nut is a popular fruit, but is among the most common addictions following tobacco, alcohol and caffeine globally. Areca nut chewing is the major risk factor for OSF, which is a chronic, occult, and premalignant fibrotic disease. OSF is characterized by submucosal collagen accumulation and microvascular diseases, the primary microscopic manifestations of which include damaged vascular endothelial cells, increased vascular permeability, and decreased number of microvessels. As the basic structure of microvessels, endothelial cells paly an important role in the pathogenesis and progression of OSF. Arecoline is the main component of areca nut. This review summarized the machenism of arecoline-inducing OSF by acting on endothelial cells, mainly including that arecoline can promote endothelial cells inducing tissue fibrosis by acting on the vascular endothelial cells and is accomplished via multiple aspects such as inhibiting the proliferation and facilitating the apoptosis of endothelial cells, affecting their secretion of cytokines, or promoting the transformation process of EMT.
The implicit stress of eating meat
Christopher Anthony David, Peter Gerard Coan
90Life Research    2018, 1 (1): 9-17.   https://doi.org/10.12032/life2018-0711-003
Abstract HTML PDF (6125KB)  

This paper gives a brief overview of the evolutionary history of human diet, discusses various reasons why some modern humans choose to abstain from eating animal products, and explores the psychological effects occasioned by the eating of meat. The authors argue that when modern, scientifically literate humans choose to eat meat and animal-milk-based products, while being simultaneously aware of the associated poor outcomes in terms of personal health, environmental sustainability, and animal suffering, then psychological stress is an inevitable outcome. They highlight some key recent additions to the growing body of evidence which demonstrates that the choice to eat meat is a factor in environmental destruction, animal misery, and personal health risks, and explore the causes and consequences of the predictable psychological stresses that result for those individuals who continue to habitually eat meat.

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