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5TMR Clinical Research  2019, Vol. 2 Issue (4): 136-147    DOI: 10.12032/TMRClinRes20191001015
    
Lower level of copper and zinc in serum confer risk to vitiligo: a systematic review and meta-analysis
Tao-Yang1, Yi-Bo Cao2, Wan-Ling Liang2, Jian-Xia Wen3, Shi-Zhang Wei3, Hao-Tian Li3, Tian-Bao Xiao2*
1Chengdu University of Traditional Chinese Medicine, Chengdu, China; 2Guizhou University of Traditional Chinese Medicine, Guiyang, China; 3The Fifth Medical Center of PLA General Hospital, Department of Pharmacy, Beijing, China.
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Abstract  

Etiology and pathogenesis of vitiligo has not been interpreted perfectly. Epidemiologic evidence about falling level of copper and zinc in blood serum increasing the risk of vitiligo remains contradictory. We investigated the association between blood serum copper and zinc with vitiligo via performing a meta-analysis. Results indicates there was a significant lower level of copper and zinc in patients with vitiligo compared with healthy population ((Z = 3.55, P = 0.000; SMDCu = −0.84, 95% CI, −1.30 to −0.38) and (Z = 5.40, P = 0.000; SMDZn = −1.01, 95% CI, −1.38 to −0.64), respectively). Meanwhile, no statistical evidence for publication bias in the end outcome. Conclusion from our finding offers a meaningful insight into lower level of copper and zinc in serum confer risk to vitiligo.



Key wordsVitiligo       Copper       Zinc       Systematic review       Meta analysis     
Published: 03 December 2019
Corresponding Authors: Tian-Bao Xiao, Guizhou University of Traditional Chinese Medicine, No 71 Baoshan North Road, Guiyang, China.    
E-mail: 872614519@qq.com
About author: 1Chengdu University of Traditional Chinese Medicine, Chengdu, China; 2Guizhou University of Traditional Chinese Medicine, Guiyang, China; 3The Fifth Medical Center of PLA General Hospital, Department of Pharmacy,Beijing, China.
Cite this article:

Tao-Yang, Yi-Bo Cao, Wan-Ling Liang, Jian-Xia Wen, Shi-Zhang Wei, Hao-Tian Li, Tian-Bao Xiao. Lower level of copper and zinc in serum confer risk to vitiligo: a systematic review and meta-analysis. 5TMR Clinical Research, 2019, 2(4): 136-147.

URL:

https://www.tmrjournals.com/tcr/EN/10.12032/TMRClinRes20191001015     OR     https://www.tmrjournals.com/tcr/EN/Y2019/V2/I4/136