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Editors-in-Chief: CG Sun PhD, Prof.
ISSN 2538-130X
4TMR Theory and Hypothesis is a peer-reviewed quarterly journal sponsored by TMR publishing group. It has been included in ScienceOpen and Google Scholar. The journal primarily aims to include innovative papers that combine these two theories with modern biomedicine, physics, chemistry and mathematic models. Hypotheses, basic and clinical researches, literature review and analysis which are carried out on a certain theory, phenomenon and development process of traditional Chinese medicine, and paper that reported the influence of traditional medicine on politics, economy, and culture can also be included. ... More


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Current Issue     20 June 2020, Volume 3 Issue 2 Previous Issue   
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Prescription and treatment rules for the prescriptions containing Poria cocos and Atractylodes macrocephala couplet medicine based on traditional Chinese Medicine inheritance support platform.
Gan-Lin Sun , Yun-Tong Wang , Yin-Zi Kong , Hong Gui , Lei Zhang
4TMR Theory and Hypothesis. 2020, 3 (2): 297-310.   https://doi.org/10.12032/TMRTH202002001
Abstract ( 29 )     PDF (877KB) ( 20 )  
Objectives: To provide a theoretical basis for the development of the new products of Poria cocos-Atractylodes macrocephala couplet medicine. Methods: All prescription preparations containing Poria cocos and Atractylodes macrocephala were collected from the Drug Standards of the Ministry of Public Health Drug Standard· Traditional Chinese Medicine Set Prescription Preparation (called Traditional Chinese Medicine Set Prescription Preparation for short). After standardization, the information of each prescription preparation was input into the Chinese Traditional Medicine Inheritance Support Platform (V2.5), and the relevant rules of the software were adopted. Data mining methods were used to analyze the frequency of drugs, main symptoms and diseases in prescriptions, and to analyze the regularity of prescriptions. The prescription rules of top 2 high frequency attending syndromes and diseases were analyzed. Results: There were total of 337 prescription preparations containing couplet medicine of Poria cocos and Atractylodes macrocephala,107 kinds of main symptoms and 66 kinds of diseases. The high frequency syndromes were deficiency of Qi and blood and weakness of spleen and
stomach, and the high frequency syndromes were anorexia and irregular menstruation. Conclusion: The couplet medicine of Poria cocos-atractylodes macrocephala prescription is mainly used to treat digestive tract diseases and gynecological diseases; it mostly takes tonifying deficiency efficat. It can treat different diseases being compatible with different medicinal materials. The study can provide theoretical basis for clinical application and new drug development of the couplet medicine of Poria cocos-atractylodes macrocephala.
Traditional Chinese medicine Qi model
Rui Chen
4TMR Theory and Hypothesis. 2020, 3 (2): 311-324.   https://doi.org/10.12032/TMRTH202002002
Abstract ( 38 )     PDF (458KB) ( 23 )  
This paper expounds the effect of "Qi" on human body by constructing the model of Qi, classifies the parts according to the category of Yin and Yang on the coordinate frame of 5 models of Yin and Yang, and compares each kind of parts according to the normal image state of human body. with the running direction of integer instead of Qi, the number of Qi in each part is calculated by the method of modern number theory, and the development and changes of human physiology and diseases are explained by "Qi". To explore the Trasitional Chinese Medicine treatment method of "the morbid Qi state of the human body adjusts the qi mode, the direction of qi operation and the intensity of Qi by means of medicinal taste and acupuncture, and returns to the normal state of qi balance mode in the direction of operation".
Age-related white matter hyperintensities: a contribution of cervical venous dysfunction
Anish Kapadia
4TMR Theory and Hypothesis. 2020, 3 (2): 325-330.   https://doi.org/10.12032/TMRTH202002003
Abstract ( 0 )     PDF (239KB) ( 3 )  
Age-related cerebral white matter hyperintensities (WMHs) are a ubiquitous finding on MRI in older individuals. They are associated with cognitive decline, dementia, disability and death. Changes are thought to result from small infarcts secondary to arteriosclerosis. However, the anatomic distribution of WMHs is often non-arterial, and one that parallels the deep venous system. There is discrepant evidence for the role of conventional vascular risk factors such as hypertension, carotid atherosclerosis and diabetes in age-related WMHs. Interventions targeting these vascular risk factors lack efficacy in preventing the progression of disease. There is evidence for age-related hemodynamic cervical venous dysfunction resulting in reduced internal jugular vein venous compliance, venous dilatation and venous reflux. Increased blood-brain barrier (BBB) permeability is also noted with aging. Both hemodynamic venous dysfunction and increased BBB permeability are associated with WMHs. It is proposed that age-related WMHs are a sequalae of venous dysfunction. Venous dysfunction results initially in increased transmission of venous pressures to the brain. Subsequent BBB disruption leads to increased permeability with progression to end-stage findings of age-related WMHs.
Broad extension of the Five-wheel theory
Wei-Dong Lai, Hang-Bo Cai, Xiao-Gu Liu
4TMR Theory and Hypothesis. 2020, 3 (2): 331-336.   https://doi.org/10.12032/TMRTH202002004
Abstract ( 15 )     PDF (288KB) ( 8 )  
Objective: To study the broad scope of the "five-wheeltheory" and perfect the theoretical system of the "fivewheel theory. Methods: By searching the literature, the five-wheel doctrine was extended in a broad sense, combining the traditional five-wheel doctrine and the related dialectical thinking mode of the inner five-wheel hypothesis.Conclusion: All the muscle fibers inside and outside the eye, including ciliary muscle and extraocular muscle, are controlled by the spleen. The soft tissues of the fascia represented by the suspensory ligament of lens, cornea, sclera, uvea and retina (except the components of blood vessels) are all dominated by the liver. The blood vessels inside and outside the eyes represented by the middle retinal artery are all controlled by the heart; the water and visual pathway represented by tear and aqueous humor (including refractive system and nerve conduction system) are controlled by the kidney, in which the secretion of glands is controlled by the spleen. The coordinated function of refractive system and visual pathway is controlled by the lung.
Bitter components related to alleviating intestinal obstruction in traditional Mongolian medicine
Hong-Zhen Yu#, Li-Sha A, Xiao-Ping Ji, Sung-Bo Cho, Gen-Na Ba, Peng-Fei Han, Ming-Hai Fu
4TMR Theory and Hypothesis. 2020, 3 (2): 337-347.   https://doi.org/10.12032/TMRTH202002005
Abstract ( 9 )     PDF (716KB) ( 12 )  
Intestinal obstruction is a blockage that keeps digesta from passing through upper or lower intestine. Traditional
Mongolian medicine (TMM) has been proven to be efficacious in the clinical treatment of intestinal obstruction.
However, the mechanism of its treatment has not been studied. The bitter taste receptors (T2Rs) are highly
expressed in the extra-oral digestive system, such as gastrointestinal tract, which can regulate gastrointestinal
peristalsis and contraction of gastrointestinal smooth muscle. In the respiratory system, T2Rs can relax the airway
smooth muscle and effectively alleviate asthma symptoms. In this review, the theory and clinical applications of
bitter herbs in TMM were discussed and the functional expression of T2Rs and bitter taste signal transduction
pathway were analyzed to investigate whether bitter Mongolian medicine may play an effective role in promoting
gastrointestinal peristalsis. Therefore, the scientific connotation of the theory of bitter medicinal property of TMM
was interpreted by combining T2Rs research and application of modern technology. This new research approach
may enrich and improve the basic theory and accelerate the modernization of TMM.

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