Uremic clearance granule combined with Alprostadil in the treatment of chronic renal failure: A systematic review and meta-analysis.
TMR Theory and Hypothesis. 2019, 2 (3): 195-203.
Objective: To evaluate whether the combination of Uremic clearance granule with Alprostadil is
superior to Alprostadil alone for CRF. Methods: Relevant RCTs were searched through March 2019.
Data were analyzed by Stata 15.0. Results: Nine articles involving 726 patients were enrolled in
this study. Meta-analysis showed that the total effective rate [OR = 3.68 (2.44, 5.55), P < 0.001], Scr
[SMD = -2.34 (-3.49, -1.19), P < 0.001], BUN [SMD = -1.80 (-2.73, -0.87), P < 0.001], Ccr [SMD
= 0.71 (0.44, 0.97), P < 0.001] were better in the experimental group. But there were no significant
difference in UA, CysC, 24h-Upro and incidence of adverse reactions (all P > 0.05) between two
groups. No serious adverse reactions were found. Conclusions: The effect of the integrated medicine
on CRF was better than Alprostadil alone. Uremic clearance granule is safe and has no obvious
Discussion on the clinical significance of moxibustion in improving cancer pain
TMR Theory and Hypothesis. 2019, 2 (3): 219-224.
In clinic, most patients with middle-late cancer suffer from cancer pain, which seriously affects
the confidence and compliance of treatment. However, the side effects of the three-step analgesic
therapy, which is widely used at present, are gradually manifested, aggravating patients' resistance
to treatment. The role of Moxibustion in relieving pain has been gradually recognized and used in
various professional fields. Because of its advantages of non-toxic side effects, simple operation,
economic benefits, pain relief and immunity enhancement, moxibustion has been paid more and
The mechanism and traditional Chinese medicine research of bone destruction and hypercalcemia in multiple myeloma
TMR Theory and Hypothesis. 2019, 2 (3): 225-228.
Multiple myeloma is a malignant proliferative disease of plasma cells. Its main feature is the
malignant proliferation of monoclonal plasma cells and the secretion of a large number of
monoclonal immunoglobulins. Because of the uncontrolled proliferation, extensive infiltration
of malignant plasma cells, and the appearance and deposition of a large number of monoclonal
immunoglobulins, normal polyclonal plasma cell proliferation and polyclonal immunoglobulin
secretion are inhibited. It can cause extensive bone destruction, hypercalcemia, repeated infection,
renal insufficiency, high viscosity syndrome and other clinical manifestations, which can alsolead
to adverse consequences.In view of these unique clinical manifestations and pathological features
of multiple myeloma, we systematically expounded the pathological characteristics of multiple
myeloma and the treatment of traditional Chinese medicine from extensive bone destruction and
hypercalcemia on the basis of Chinese and Western medicine. In order to provide theoretical support
and clinical guidance for the treatment of multiple bone marrow tumors with bone destruction and