21 April 2020, Volume 2 Issue 2 Previous Issue   
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Novel immunotherapy strategy based on tumor microenvironment
Qi-Fan Luo, Yi -Ming Zhao
93Tumor Microenvironment Research. 2020, 2 (2): 34-41.   https://doi.org/10.12032/TMER201900011
Abstract ( 66 )     PDF (299KB) ( 91 )  
Recent advances in molecular and cellular tumor immunology have demonstrated that immunotherapy might have great potential, which would be another important treatment strategy after surgery, radiotherapy and chemotherapy. Therefore, this review mainly summarizes and discusses the classification of tumor immune microenvironment and the existing main immunotherapies, in order to provide some guidance and suggestions for accurate individualized immunotherapy.
Tumor microenvironment
Jian Lu, Feng Qi
93Tumor Microenvironment Research. 2020, 2 (2): 42-49.   https://doi.org/10.12032/TMER201900012
Abstract ( 102 )     PDF (302KB) ( 60 )  
The tumor microenvironment (TME) is widely related to the occurrence of tumors, because tumor cells interact with surrounding cells and tissues through the lymphatic system and blood channel metastasis, thus affecting the occurrence and development of cancer. Non-malignant cells in the TME play a vital role in the development of cancer by stimulating and promoting uncontrolled cell proliferation. Previous studies have identified various components of the TME that influence malignant behavior and progression. Non-tumor cells such as adipocytes, tumor vasculature, lymphocytes, dendritic cells, and cancer-related fibroblasts exist in the TME. Each type of cell or acellular component has a unique immune capacity or function that is critical to the survival of the tumor and its effect on neighboring cells. Therefore, targeting and manipulating the cells and matrix in the TME during cancer treatment can help to treat malignancies and provide patient survival.
Research progress of macrophages and tumor progression
Xiao-Dong Wang
93Tumor Microenvironment Research. 2020, 2 (2): 50-59.   https://doi.org/10.12032/TMER201900013
Abstract ( 104 )     PDF (352KB) ( 86 )  
The tumor microenvironment refers to the internal environment in which tumor cells grow in the tumor tissue, and is composed of the tumor cells themselves, stromal cells, immune cells, microvessels, interstitial cells, interstitial fluid, and biomolecules infiltrating immune cells. Tumor-associated macrophages are macrophages that infiltrate the tumor tissue, and are the most frequent immune cells in the tumor microenvironment. The macrophages could secrete a variety of cytokines and can recognize, identify and clear the tumor cells. However, as the tumor develops, it plays a key role in the growth, invasion and metastasis of the tumor. Cancer cells will “hire” macrophages by giving them colony stimulating factors and CD47 protein to help them with tumor angiogenesis, metastasis, and drug resistance, stimulate tumor growth, and even phagocytose PD-1 antibodies to protect cancer cell. In response to the relationship between macrophages and tumors, more and more scientists have begun to think about how to design new antibody drugs based on their mechanism and turn them into another hero in the field of immunotherapy.
Research progress of triple-negative breast cancer immunotherapy
Jin-Feng Liu
93Tumor Microenvironment Research. 2020, 2 (2): 60-65.   https://doi.org/10.12032/TMER201900014
Abstract ( 64 )     PDF (278KB) ( 39 )  
Breast cancer is the most common type of female malignancy in the world. Triple-negative breast cancer refers to breast cancer in which the expressions of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 are all negative. It has the clinical characteristics of easy invasion, high recurrence rate and short survival time. At present, there is a lack of effective treatment in the clinic. Following surgical treatment, chemotherapy, endocrine therapy, and molecular targeted therapy, a new type of treatment, immunotherapy, is of great significance for the treatment of triple-negative breast cancer.
Research progress on the role of tumor microenvironment in tumor metastasis
Xiao-Hui Liu
93Tumor Microenvironment Research. 2020, 2 (2): 66-70.   https://doi.org/10.12032/TMER201900015
Abstract ( 53 )     PDF (269KB) ( 37 )  
Tumor metastasis is the basic feature and important sign of malignant tumors, and the main cause of death for most cancer patients. The tumor microenvironment is closely related to tumor metastasis and a deep understanding of the relationship between tumor microenvironment and tumor metastasis has positive guiding significance for the prevention and treatment of tumors. The occurrence, development and metastasis of tumors involve a series of complex biological processes. In the process of tumor metastasis, the tumor microenvironment cooperates with tumor cells. Tumor microenvironment is composed of cellular components, physical components and biochemical components, and it participates in important biological processes such as tumor growth, invasion, metastasis, neovascularization, immune escape, and tumor drug resistance. The study of tumor microenvironment can help us better understand the biological behavior of tumor and control the occurrence, development and metastasis of tumor.


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