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Traditional Medicine Research  2016, Vol. 1 Issue (1): 2-10    DOI: 10.12032/TMR201601002
Orginal Article     
Effects and safety of acupuncture for DFUs: a systematic review and meta-analysis
Yi Li-Juan1,*, Tian Xu1,*, Shuai Ting1, Zeng Zi1, Ma Li1, Song Guo-Min2,**()
1Master degree candidate, Graduate College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
2Director of Nursing, Nursing Department of Tianjin Hospital, Tianjin 400020, China.
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Objective:To systematically evaluate the effect and safety of acupuncture for the treatment of diabetic foot ulcers(DFUs).Methods:Six databases, including Pubmed, Web of Science, EMbase, the Cochrane Library, the Chinese Biomedical Literature Database (CBM), and the China National Knowledge Infrastructure (CNKI), were electronic searched for randomized controlled trials (RCTs). Retrieval periods from each database were stopped until30 October, 2014. Cochrane risk of bias assessment tool was used to assess the methodological quality of included studies. Results:A total of 8 trials involving 481 participants met the inclusion criteria. The results of meta and descriptive analysis suggested that acupuncture effectively improved total effective rate of DFUs,shortened ulcer healing time , and improved the blood flow volume,but acupuncture did not ameliorate vessel diameter and peak velocity. No serious adverse events were identified in acupuncture group.Conclusions:Acupuncture is more effective in shortening overall treatment time. Acupuncturehas advantages over the control group in curative effect.

Key wordsDiabetic      foot      ulcers,Acupuncture,      Systematic      review,Meta-analysis     
Published: 06 November 2015
Corresponding Authors: Yi Li-Juan,Tian Xu,Song Guo-Min     E-mail:
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Executive Editor: Cui-Hong Zhu

English Editor: Lin Li, Li-Yun-Cui, Ya-Song Wang, Xiao-Hua Zhang, Xiao-Dong Wang, Hong-Xu Zhu, Zhen-Yan Liu, Yi-Cheng Shi

Cite this article:

Yi Li-Juan, Tian Xu, Shuai Ting, Zeng Zi, Ma Li, Song Guo-Min. Effects and safety of acupuncture for DFUs: a systematic review and meta-analysis. Traditional Medicine Research, 2016, 1(1): 2-10. doi: 10.12032/TMR201601002

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Figure1 PRISMA flow diagram of reteriveal and selection of literature.
Studies included Methods No. Of Case
Interventions Age(T/C) Outcomes
Study group (T) Control group (C)
Zhanga 2003[7] Computerised randomisation schedule 43/32 Warm-needle techniques with basic therapy plus external therapy Chinese herbal medicine with basic therapy plus external therapy 59.6±12.32/58.3±11.79 Ⅰ+Ⅲ+Ⅳ
Zhangb 2003[8] Computerised randomisation schedule 43/32 Warm-needle techniques with basic therapy plus external therapy Western medicine with basic therapy plus external therapy 59.6±12.32/58.6±11.9 Ⅰ+Ⅲ+Ⅳ
Yi 2007[9] Rrder of admission 32/31 Acupuncture with moxibustion plus basic therapy Basic therapy 51~75/52~74 Ⅰ+Ⅲ
Chen 2010[10] NA 27/27 Moxibustion massager with basic therapy plus dressing change Basic therapy with dressing change 56.7±11.3/54.6±12.7
Zhong 2011[11] Registration order 38/38 Acupoint injection with basic therapy Basic therapy 65.9±10.1/65.9±10.1 Ⅰ+Ⅲ+Ⅳ
Liu 201112] NA 26/26 Moxibustion with eroded debridement plus Compound Sihuang wet Eroded debridement with Compound Sihuang wet 60.1±9.3/62.5±8.1 Ⅰ+Ⅱ
Liu 2014[13] NA 20/20 Moxibustion with basic therapy Basic therapy 43.5±6.9/42.8±6.9
Ma 2013[14] NA 15/13 Moxibustion with routine dressing change Comfeel transparent dressing with routine dressing change 70~86/70~86 Ⅰ+Ⅱ
Qi 2013[15] Tableof random numbers 31/30 Moxibustion with complex treatment Complex treatment 52.6±20.8/54.1±17.3 Ⅰ+Ⅲ+Ⅳ
Table 1 Characteristics of 9 trials identified in the literature search.
Figure2 Risk of bias summary:authors' judgments about each risk of bias item for included studies.
Figure 3 Risk of bias graph: authors' judgments about each risk of bias item for included studies.
Figure 4 Meta-analysis for total effective rate.
Figure 5 Meta-analysis for the ulcer healing time.
Figure 6 Meta-analysis for VD.
Figure 8 Meta-analysis for blood flow volume.
Figure 9 Egger’s funnel plot of publication bias.
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