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Traditional Medicine Research  2016, Vol. 1 Issue (1): 32-42    DOI: 10.12032/TMR201601005
    
Massage for migraine: A meta-analysis
Xiao-YiTang1, Wen-RuShang3, Zhi-WenWeng1, Rui-JinQiu2, Jin-HuiTian3, Yan-GangLiu1,*(), Gui-HuaTian1,2,*()
1TuiNa and Pain Department and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, 100700 Beijing, China.
2Key Laboratory of Chinese Internal Medicine of MOE and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, 100700, Beijing, China.
3Evidence-based Medicine Center, Lanzhou University, Lanzhou, 730000,China.
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Objective:This systematic review examined whether massage interventions provided any measurable benefit in migraine disorders. Methods:Randomized controlled trials (RCTs) were searched for in Cochrane Library, PubMed, Web of Science, China Knowledge Resource Integrated Database (CNKI), and WanFang Data from inception to October 2015. Two researchers independently selected literatures according to the inclusion criteria, and used the risk of bias assessment tool in Reviewer Handbook 5.1.0 for quality evaluation. Meta-analyses were performed with RevMan 5.3 software. GRAED pro GDT was used to evaluate the quality of evidence. Results:In summary, 18 RCTs with2025 patients and 1947 cases were included in meta-analyses. Analysis results showed that 1) compared with conventional drug therapies, massage therapies significantly improved the effective rate with statistically significant difference (RR=1.25, 95%CI (1.19, 1.32), P<0.00001); 2) the difference between massage and acupuncture was not statistically significant (RR=0.94, 95%CI (0.77, 1.16), P>0.05). In addition, compared with acupuncture only, a combined approach of massage and acupuncture significantly improved the effective rate with statistically significant difference (RR=1.11, 95%CI (1.06, 1.17), P<0.0001). Conclusion:As comparable to acupuncture, massage is an effective therapy for migraine, both massage and acupunctureshow clear benefits over conventional drug therapies.



Key wordsMassage      Migraine      Systematic Review      Meta-Analysis      Randomized Controlled Trial     
Published: 25 December 2015
Corresponding Authors: Yan-GangLiu,Gui-HuaTian     E-mail: lpl6316@126.com.;rosetgh@163.com
About author: Executive Editor: Cui-Hong Zhu English Editor: Lin Li, Li-Yun-Cui, Ya-Song Wang, Xiao-Hua Zhang, Xiao-Dong Wang, Hong-Xu Zhu, Zhen-Yan Liu, Yi-Cheng Shi
Cite this article:

Xiao-Yi Tang, Wen-Ru Shang, Zhi-Wen Weng, Rui-Jin Qiu, Jin-Hui Tian, Yan-Gang Liu, Gui-Hua Tian. Massage for migraine: A meta-analysis. Traditional Medicine Research, 2016, 1(1): 32-42. doi: 10.12032/TMR201601005

URL:

https://www.tmrjournals.com/tmr/EN/10.12032/TMR201601005     OR     https://www.tmrjournals.com/tmr/EN/Y2016/V1/I1/32

Figure 1 Study flow diagram.
Study Number
(T/C)
Age
(T/C)
Gender
(man/woman)
T C
Intervention Control Outcome
measurement
Liao 2015 39/39 38.45/39.28 14/25 12/27 Massage+routine nursing care(1/w) Routine nursing care Effective rate,quality of life score
Hu 2004 60/20 - 28/32 10/10 Massage/massage+acupuncture
(1/2d)
Acupuncture(qd) Effective rate
Zhan 2014 50/50 41.3/40.7 20/30 19/31 Massage+
acupuncture(qd)
Acupuncture(qd) Effective rate
Ye 2004 30/30 - 21/39 Massage(qd) Flunarizine
(10mg,qd)
Effective rate
Lv 2006 46/40 - 47/39 Massage+
acupuncture(qd)
Acupuncture(qd) Effective rate
Yao 1996 50/48 - 16/34 17/31 Massage+
acupuncture(qd)
Acupuncture(qd) Effective rate
Zhuang 1998 32/30 - 20/42 Massage(qd) Flunarizine
(10mg,qd)
Effective rate,adverse events
Zhang 2014 30/30 37.43/39.63 10/20 11/19 Massage(1/2d) Acupuncture(qd) Effective rate,TCD
Zhang 2004 130/70 - 61/69 28/42 Massage Compound aminopyrine and caffeine tablets
(2/tid),zhengtian pill
(6g/tid),jingfukang tablets(1/bid)
Effective rat,adverse events
Li 2013 80/80 36.2/33.3 27/53 30/50 Massage+
acupuncture(qd)
Acupuncture(qd) Effective rate
Pan 2007 80/32 - 60/52 Massage(qd) Flunarizine(5mg,qd),aspirin
(0.3g,tid)
Effective rate
Yan 2006 260/100 - 107/153 38/62 Massage(qd) Flunarizine
(5mg,qd),aspirin
(0.3g,tid)
Effective rate
Wang 2009 50/50 36.4/37.1 15/35 17/33 Massage(qd) Flunarizine
(10mg,qd)
Effective rate,
plasma monoamine neurotransmitter
Gan 2012 40/40 42/40 16/24 14/26 Massage Flunarizine
(5mg,qd)
Effective rate
Jia 2011 30/30 - - - Massage(1/2d) Zhengtian pill(6g,tid) VITAS, Effective rate
Zou 1994 75/75 43 66/84 Massage+
acupuncture(qd)
Acupuncture(qd) Effective rate
Guo 1999 35/31 29.5 21/45 Massage(qd) Propranolol,aspirin,oryzanol Effective rate
Wei 2011 57/56 36.6/37.7 25/32 27/29 Massage(qd) Nimodipine (40mg,tid) Effective rate,ET,NO
Table 1 Basic characteristics of included studies.
Figure 2 Graph of Risks of bias.
Figure 3 Summary of risks of bias.
Figure 4 Forest plot of comparison:Effective rate of massage versus regular drugs.
Figure 5 Forest plot of comparison: Effective rate of massage versus acupuncture.
Figure 6 Forest plot of comparison:Effective rate of massage + acupuncture versus acupuncture.
Massage versus regular drugs Quality Importance
№ of studies Study design Risk of bias Inconsistency Indirectness Imprecision Other considerations
10 randomised trials serious 1 not serious not serious not serious none ⊕⊕⊕?
MODERATE
IMPORTANT
Massage versus acupuncture Quality Importance
№ of studies Study design Risk of bias Inconsistency Indirectness Imprecision Other considerations
2 randomised trials serious2 not serious not serious serious 3 none ⊕⊕??
LOW
IMPORTANT
Massage plus acupuncture versus acupuncture Quality Importance
№ of studies Study design Risk of bias Inconsisteny Indirectness Imprecision Other considerations
6 randomised trials serious 4 not serious not serious not serious none ⊕⊕⊕?
MODERATE
IMPORTANT
Table 2 * Summary of quality assessments.
Figure 7 Funnel plot of comparison:3.4.1.1 Effective rate of massage versus regular drugs.
Figure 8 Funnel plot of comparison:3.4.1.3 Effective rate of massage + acupuncture versus acupuncture
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