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Traditional Medicine Research  2016, Vol. 1 Issue (1): 52-57    DOI: 10.12032/TMR201601007
Orginal Article     
Complete response of hepatocellular carcinoma treated with traditional Chinese medicine treatment: A case report
Cui-HongZhu1, Hao Jian1, Yang Xue1, Wang Xiao-Dong1, Xiong-ZhiWu1,*
1 Zhong-Shan-Men Inpatient Department, National Clinical Research Center for Cancer
Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300171, China
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We reported a detailed clinical course of complete response of hepatocellular carcinoma(HCC) with traditional Chinese medicine(TCM) treatment in the present study. In June 2011, a 47-year-old man was admitted to our hospital for multiple mass lesions in liver. Abdominal contrast-enhanced CT revealed multiple low density nodules with heterogeneous enhancementin his right lobe of the liver and the largest nodule diameter was about 5 cm. The clinical diagnosis was hepatocellular carcinoma (diffuse-type). Resection was not performed considering the patient’s poor physical condition. He received THM therapy as an alternative. One months later, CT showed that the majority lesions of the right liver lobe shrank. In November 2014, CT showed that the liver lesions completely disappeared and had no evidence of tumor recurrence. Our case provides additional evidence to show that TCM treatment is effective for patients with HCC, and it can achieve complete remission, long disease-free survival and provide patients with good quality of life.

Key wordsHepatocellular carcinoma      Complete response      traditional Chinese medicine     
Published: 28 December 2016
Corresponding Authors: Xiong-ZhiWu   
About author:

Executive Editor: Cui-Hong Zhu

English Editor: Lin Li, Li-Yun-Cui, Ya-Song Wang, Xiao-Hua Zhang, Xiao-Dong Wang, Hong-Xu Zhu, Zhen-Yan Liu, Yi-Cheng Shi

Cite this article:

Cui-HongZhu, Hao Jian, Yang Xue, Wang Xiao-Dong, Xiong-ZhiWu. Complete response of hepatocellular carcinoma treated with traditional Chinese medicine treatment: A case report. Traditional Medicine Research, 2016, 1(1): 52-57. doi: 10.12032/TMR201601007

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Figure 1 Arterial phase scans of contrast enhanced multiphase computed tomogram of abdomen. A:Abdominal CT scan showed multiplelow density nodules with heterogeneous enhancement in his right lobe of the liver and the largest nodule diameter was about 5 cm. B:Abnormal strengthening signals inright lobe of the liver mostly disappeared in 1 mo-follow-up CT scans.C:Ony multiple nodular sclerosis were noted in 8 mo-follow-up CT scans. D: There was no arterial enhancing viable portion in his right lobe of the liver in abdominal CT scans 37 months after treatment of TCM.
Variable Characteristics
Age, y 43
Gender Male
Nationality Mongol
Child-Pugh score B
AFP 10.5
Primary tumor size (cm) 5
Number oftumors Multiple
Extrahepatic metastases No
Presence of portal vein tumor thrombus No
Surgical resection No
Time of TCM treatment (month) 37months
Survival status Survival(CR)
Table1 Patient baseline characteristics.
2011.6.23 Codonopsis pilosula(党参)30g Nidus Vespae(蜂房)10g Lilac Pink Herb(瞿麦)30g Prepared Jackinthepulpit Tuber(制天南星)30g Gekko japonicus Dumeril et Bibron(天龙)5g Turtle processed with vinegar(醋鳖甲)10g Chinese thorowax root(柴胡)24g Liquorice root(甘草)3g Adlay(薏苡仁)60g Baical skullcap root(黄芩)10g Nightshade(龙葵)15g India madder root(茜草)30g Mealy fangji root(防己)30g Campsis grandiflora(凌霄花)6g Endothelium corneum gigeriae galli(鸡内金)10g Paniculate bolbostemm(土贝母)6g Phytolacca processed with vinegar(醋商陆)9g Processed pinellia tuber(法半夏)9g Radix Notoginseng(三七)2g
2011.7.22 add Bile arisaema(胆南星)30g Root of Valvate Actinidia(猫人参)30g Turmeric root tuber (郁金)10g
subtract Prepared jackinthepulpit tuber制天南星30g
2011.8.26 add Herba Hedyotis(白花蛇舌草)30g Seaweed(海藻)30g
subtract Nidus Vespae(蜂房)10g Liquorice root(甘草)3g Adlay(薏苡仁)60g Baical skullcap root(黄芩)10g
2012.6.5 Radix Notoginseng(三七)2g Phytolacca processed with vinegar(醋商陆)9g Gekko japonicus Dumeril et Bibron(天龙)6g Chinese thorowax root(柴胡)24g Radix Codonopsis(党参)30g Trumpetcreeper flower(凌霄花)6g Lilac pink herb瞿麦30g Turtle processed with vinegar(醋鳖甲)10g Nightshade(龙葵)15g endothelium corneum gigeriae galli鸡内金10g Mealy fangji root(防己)30g Paniculate bolbostemm(土贝母)6g Processed pinellia tuber(法半夏)9g Root of Valvate Actinidi(猫人参)30g European verbena herb(马鞭草)30g Pericarpium Arecae(大腹皮)30g Rhizoma Curcumae Longae(姜黄)6g Baical skullcap root(黄芩)10g cassia twig(桂枝)12g White peony root(白芍)10g Dried ginger(干姜)3g Radix Trichosanthis(天花粉)10g Oyster shell(牡蛎)20g Roasted licorice(炙甘草)3g
2012.7.31 add Nidus Vespae by stir-frying(炒蜂房)6g Radix Actinidiae Chinensis(藤梨根)30g Akebia fruit(预知子)3g
subtract Radix Notoginseng(三七)2g Lilac pink herb(瞿麦)30g Gekko japonicus Dumeril et Bibron(天龙)6g Rhizoma Curcumae Longae(姜黄)6g Root of Valvate Actinidia(猫人参)30g
2012.11.13 add Radix Notoginseng(三七)2g Lilac pink herb(瞿麦)30g Gekko japonicus Dumeril et Bibron(天龙)6g Rhizoma Curcumae Longae(姜黄)6g Root of Valvate Actinidia(猫人参)30g
subtract Processed pinellia tuber(法半夏)6g Nidus Vespae by stir-frying炒蜂房6g Radix Actinidiae chinensis(藤梨根)30g Akebia fruit(预知子)3g
2013.11.14 add Fresh bone fossil of big mammals生龙骨15g Coix seed(薏苡仁)10g
subtract Rhizoma Atractylodis Macrocephalae(白术)20g oyster shell(牡蛎)15g
Table2 Prescriptions of traditional Chinese medicine treatment.
1   1.Min S K, Jin Y J, Lee J W, et al. Complete remission of advanced hepatocellular carcinoma by sorafenib: A case report[J]. World Journal of Gastrointestinal Oncology, 2013, 5(02):38-42.
doi: 10.4251/wjgo.v5.i2.38 pmid: 23556056
2.   Demirjian A, Peng P, Geschwind JF, Cosgrove D, Schutz J, Kamel IR, Pawlik TM: Infiltrating hepatocellular carcinoma: seeing the tree through the forest. J Gastrointest Surg 2011, 15:2089-2097.
doi: 10.1007/s11605-011-1614-7 pmid: 3580771
3   3.Takeda Y, Wakui N, Asai Y, et al. Spontaneous complete necrosis of hepatocellular carcinoma: A case report and review of the literature[J]. Oncology Letters, 2015, 9(4):1520-1526(7).
4.   Kanematsu M, Semelka RC, Leonardou P, Mastropasqua M, Lee JK: Hepatocellular carcinoma of diffuse type: MR imaging findings and clinical manifestations. J Magn Reson Imaging 2003, 18:189-195.
doi: 10.1002/jmri.10336 pmid: 12884331
5.   Yang JD, Roberts L: Epidemiology and management of hepatocellular carcinoma. Infect Dis Clin North Am 2010, 24:899-919.
doi: 10.1016/j.idc.2010.07.004 pmid: 20937457
6   6.Song L, Zhang Y, Zhao G, et al. Complete remission of diffuse hepatocellular carcinoma in a young adult after GSP-TACE: a case report[J]. World Journal of Surgical Oncology, 2014, 12(1):1-4.
doi: 10.1186/1477-7819-12-300 pmid: 25256211
7.   World Health Organization, International Agency for Research on Cancer. GLO-BOCAN 2008. (
8   8.Lau W Y, Lai E C. The current role of radiofrequency ablation in the management of hepatocellular carcinoma: a systematic review.[J]. Annals of Surgery, 2009, 249(1):20-25.
9   9.Yang, Xue, Hao, Jian, Zhu, Cui-Hong, et al. Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer[J]. Medicine, 2015, 94.
doi: 10.1097/MD.0000000000001008 pmid: 26131801
10   10.Ya-Nan, Man, Xiao-Hui, Liu, Xiong-Zhi, Wu. Chinese medicine herbal treatment based on syndrome differentiation improves the overall survival of patients with unresectable hepatocellular carcinoma[J]. Chinese Journal of Integrative Medicine, 2015, 21(1):49-57.
11.   Ruan W. J.; Lai M. D.; Zhou J. G.,Anticancer effects of Chinese herbal medicine, science or myth? J Zhejiang Univ Sci B 2006, 7(12), 1006-14.
12.   Tan W.; Lu J.; Huang M.; Li Y.; Chen M.; Wu G.; Gong J.; Zhong Z.; Xu Z.; Dang Y.; Guo J.; Chen X.; Wang Y.,Anticancer natural products isolated from chinese medicinal herbs.Chin Med 2011, 6(1), 27.
doi: 10.1186/1749-8546-6-27 pmid: 3149025
13.   Hsiao W. L.W.; Liu, L., The role of traditional Chinese herbal medicines in cancer therapy--from TCM theory to mechanistic insights. Planta medica 2010, 76(11), 1118-31.
doi: 10.1055/s-0030-1250186 pmid: 20635308
14.   Konkimalla V. B.; Efferth T.,Evidence-based Chinese medicine for cancer therapy. J Ethnopharmacol 2008, 116(2), 207-10.
doi: 10.1016/j.jep.2007.12.009 pmid: 18243610
15   15.Fan, Cheung, Xuanbin, Wang, Ning, Wang, et al. Chinese Medicines as an Adjuvant Therapy for Unresectable Hepatocellular Carcinoma during Transarterial Chemoembolization: A Meta-Analysis of Randomized Controlled Trials.[J]. Evidence-based Complementary and Alternative Medicine : eCAM, 2013, 2013(3):487919-487919.
doi: 10.1155/2013/487919 pmid: 0059001
16.   Lee YW, Chen TL, Shih YR, et al.Adjunctive traditional Chinese medicine therapy improves survival in patients with advanced breast cancer: a population-based study. Cancer 2014; 120:1338-1344.
doi: 10.1002/cncr.28579 pmid: 24496917
17.   Xu Y, Zhao AG, Li ZY, et al.Survival benefit of traditional Chinese herbal medicine (a herbal formula for invigorating spleen) for patients with advanced gastric cancer. Integr Cancer Ther 2013; 12:414-422.
doi: 10.1177/1534735412450512 pmid: 22781545
18   18.Xianjiao Z, Xu T, Hanqiang L, et al. Autophagy induced by baicalin involves downregulation of CD147 in SMMC-7721 cells in vitro[J]. Oncology Reports, 2012, 27(4):1128-1134.
19.   Li-Weber M: New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev 35: 57-68, 2009.
20   20.Xin T, Zhang F, Jiang Q, et al. The inhibitory effect of a polysaccharide from Codonopsis pilosula on tumor growth and metastasis in vitro.[J]. International Journal of Biological Macromolecules, 2012, 51(5):788-793.
doi: 10.1016/j.ijbiomac.2012.07.019 pmid: 22829051
21   21.Yingpin T, Chunling H, Yanwen L. Effect of bioactive peptide of Carapax Trionycis on TGF-β1-induced intracellular events in hepatic stellate cells[J]. Journal of Ethnopharmacology, 2013, 148(1):69-73.
22   22.Lv X, Li M, Weng M, et al. Effects of the aqueous extracts of Red Peony Root and India Madder Rooton on proliferation and collagen metabolism of dermal fibroblasts from systemic sclerosis[J]. Pharmacology & Clinics of Chinese Materia Medica, 2007.
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