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Traditional Medicine Research  2017, Vol. 2 Issue (1): 1-7    DOI: 10.12032/TMR201705031
Special Issue of Chinese Herbs     
Metabonomics/metabolomics analysis technology and its application in quality control of traditional Chinese medicines
Yan Yu1(), Wang Shao-Hui1, Wei Xu Dong1, Ma Si-Bu1, Liu Tong-Xiang1,*()
1 Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing, 100081, China.
2 Key Laboratory for Chinese Minority Traditional Medicine of Ministry of Education, Beijing, 100081, China.
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This article systematically addresses metabolomics/metabonomics techniques and examples of their use in evaluation of traditional Chinese medicines. It provides a new reference for Chinese medicines and the identification and quality assessment of their products. In recent years, 1H-NMR metabonomics technology has matured. LC-MS and GC-MS metabonomics technologies have also evolved. These three analytical techniques have a good developing prospect on quality control and identification of species used in Chinese medicines, but this three techniques have their own advantages and disadvantages, Therefore, the future development should combine 1H-NMR technique with LC-MS, GC-MS techniques, and learn from each other in order to make greater contribution to the quality control of Chinese medicines.

Chinese medicines are an important part of traditional Chinese medicines, but their "safe, effective, stable and controllable" issue still remains to be solved. The rise of metabonomics in 20th century, consistent with the overall adjustment concept of multi-component, multi-level, multi-target, multi-metabolic pathways of traditional Chinese medicines, is conducive to solve basic problems in their quality control. This paper systematically describes recent application and development of 1H-NMR metabonomics techniques, LC-MS metabonomics techniques and GC-MS metabonomics techniques in the quality control of traditional Chinese medicines. It provides a new reference for Chinese medicines and the identification and quality assessment of their products.

Key wordsChinese medicines      Metabonomics      Quality control      LC-MS     
Published: 05 January 2017
Corresponding Authors: Liu Tong-Xiang     E-mail:;
Cite this article:

Yan Yu, Wang Shao-Hui, Wei Xu Dong, Ma Si-Bu, Liu Tong-Xiang. Metabonomics/metabolomics analysis technology and its application in quality control of traditional Chinese medicines. Traditional Medicine Research, 2017, 2(1): 1-7. doi: 10.12032/TMR201705031

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Figure 1 Process of metabonomics studies on Chinese medicines
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