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Traditional Medicine Research  2017, Vol. 2 Issue (1): 8-17    DOI: 10.12032/TMR201705032
Review     
The effect of foot bath of Chinese medicine combined with acupoint injection for diabetic peripheral neuropathy: a meta analysis
Fan Yi-Hua1,*(), Zhang Qiang2, Tian Rong1, Jiang Jian-Hang1
1Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China
2Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
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Highlights:

Clinical trials have shown foot bath of Chinese medicine combined with acupoint injection may have significant therapeutic efficacy for the treatment of DPN. However, most of the researches were based on small samples. This study valuated the efficacy of FBCMCAI in the treatment of DPN by Meta analysis. It provided reference for clinicians seeking effective treatments for DPN.

Abstract

Objective:The aim of this systematic review was to assess the effect of foot bath of Chinese medicine combined with acupoint injection (FBCMCAI) on patients with diabetic peripheral neuropathy (DPN). Methods: Databases such as Cochrane Library, Pubmed, Web Of Science, China Biology Medicine (CBM),CNKI,VIP and WANFANG DATA were electronically searched to collect the randomized controlled trials (RCTs) (up to October 2016). According to the inclusion and exclusion criteria, literature about effects of FBCMCAI in the treatment of DPN were screened and data were extracted. Literature quality evaluation was appliced by Cochrane Reviewer Handbook 5.1.0. A random or a fixed effects model was used to analyze outcomes by RevMan 5.3 software. Subgroup analysis, sensitivity analysis, and orientation description were performed if necessary. Results: 11 randomized controlled trials with a total of 927 patients were included. Meta analysis results revealed that the efficacy of FBCMCAI for DPN was significantly superior to the control treatment (OR=5.07, 95%CI: 3.23-7.94, Z=7.08, P<0.00001). Besides, there was an increase in motor conduction velocity of peroneal nerve (SMD=1.08, 95%CI: 0.66 - 1.48,Z=5.30, P<0.00001) , motor conduction velocity of tibial nerve (SMD=1.08, 95%CI: 0.58-1.58, Z=4.22, P<0.0001) and motor conduction velocity of median nerve (SMD=0.46, 95%CI: 0.23-0.68, Z=3.96, P<0.0001) in FBCMCAI groups. For another, there was also an increase in sensory motor conduction velocity of the motor nerve (SMD=0.80,95%CI: 0.54 -1.05, Z=6.06, P<0.00001) and sensory motor conduction velocity of median nerve (SMD=0.66, 95%CI: 0.38-0.93, Z=4.73, P<0.00001) in the FBCMCAI groups. Symptoms score was significantly reduced after FBCMCAI treatment (WMD=-4.21, 95%CI[-4.95, -3.48], Z=11.25, P<0.00001). Conclusion:FBCMCAI may have significant therapeutic efficacy for the treatment of DPN. Diabetic neurologic symptoms and nerve conduction velocities can be improved under FBCMCAI treatment. In-depth research and high quality randomized controlled trials on the efficacy of FBCMCAI are necessary.



Key wordsFoot bath of Chinese medicine      Acupoint injection      Diabetic peripheral neuropathy     
Published: 05 January 2017
Corresponding Authors: Fan Yi-Hua     E-mail: 765470599@qq.com.
About author: Executive Editor: Cui-Hong Zhu English Editor: Lin Li, Xiao-Hua Zhang, Xiao-Hui Liu.
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Cite this article:

Fan Yi-Hua, Zhang Qiang, Tian Rong, Jiang Jian-Hang. The effect of foot bath of Chinese medicine combined with acupoint injection for diabetic peripheral neuropathy: a meta analysis. Traditional Medicine Research, 2017, 2(1): 8-17. doi: 10.12032/TMR201705032

URL:

https://www.tmrjournals.com/tmr/EN/10.12032/TMR201705032     OR     https://www.tmrjournals.com/tmr/EN/Y2017/V2/I1/8

Figure 1 Study flow diagram
Study Number Age Intervention Control Outcomes
T C T C
Zhou 2015 39 39 _ _ Acupoint injection of Compound Danshen Injection + Foot bath of Chinese medicine Static drops of lipoic acid Total clinical effective rate, Nerve conduction velocity
He et.al 2013 30 30 64.13±7.50 65.06±10.5 mecobalamin acupoint injection +Foot bath of Chinese medicine Foot bath of Chinese medicine Total clinical effective rate, Nerve conduction velocity
Dai 2011 34 34 28-82 23-89 methylcobalamin +vitamine B1 acupoint injection Methylcobalaminvplus Vitamine B1 acupoint injection Total clinical effective rate
+Foot bath of Chinese medicine
Chen et al 2013 40 40 60.27±6.10 59.89±6.34 xiangdan injection acupoint injection +Foot bath of Chinese medicine Oral MeCobalamin Tablets Total clinical effective rate,Nerve conduction velocity
Liu 2015 57 57 57.19±12.93 55.03±13.09 mecobalamin acupoint injection+ Foot bath of Chinese medicine Muscle injection of Methycobal Nerve conduction velocity,
TCM syndrome scores
Su 2014 30 30 58.64±7.32 56.51±8.19 mecobalamin acupoint injection+ Foot bath of Chinese medicine Muscle injection of Methycobal Nerve conduction velocity,
TCM syndrome scores, Total clinical effective rate
Jiang 2014 56 56 62.75±5.81 61.87±6.13 mecobalamin acupoint injection, Foot bath of Chinese medicine Oral MeCobalamin Tablets Nerve conduction velocity
Zhao et al 2011 49 51 28-76 28-76 vitamine B1 acupoint injection+ Foot bath of Chinese medicine Foot bath of Chinese medicine Total clinical effective rate
Zhang et al 2016 48 47 36-86 36-86 vitamine B1 acupoint injection+ Foot bath of Chinese medicine Foot bath of Chinese medicine Nerve conduction velocity, TCM syndrome scores
Zhang 2014 35 35 59.2±2.1 58.8±2.0 Acupoint injection of Compound Danshen Injection+
Foot bath of Chinese medicine
Static drops of lipoic acid Total clinical effective rate, Symptom and sign score,
Nerve conduction velocity
Zhang 2016 45 45 50.72±12.35 52.91±11.16 xiangdan injection acupoint injection+ Foot bath of Chinese medicine Oral MeCobalamin Tablets Total clinical effective rate
Table 1 Basic characteristics of included studies
Figure 2 Graph of Risks of bias.
Figure 3 Summary of risks of bias.
Figure 4 Effective rate of FBCMCAI in the treatment of DPN.
Figure 5 Effects of FBCMCAI on MCV of peroneal nerve in patients with DPN.
Figure 6 Effects of FBCMCAI on MCV of tibial nerve in patients with DPN.
Figure 7 Effects of FBCMCAI on MCV of median nerve in patients with DPN.
Figure 8 Effects of FBCMCAI on SCV of peroneal nerve in patients with DPN.
Figure 9 Effects of FBCMCAI on SCV of median nerve in patients with DPN.
Figure 10 Meta-analysis on TCM syndrome scores in patients with DPN.
Figure 11 Funnel plot for assessing publication bias.
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