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Traditional Medicine Research  2018, Vol. 3 Issue (1): 52-61    DOI: 10.12032/TMR201809064
Empirical Formula Research     
Data mining analysis of Professor Liu Shangyi’s prescription characteristics in clinical medicine for the treatment of cancer patients with stomachache
Wen-Qi Huang1, Zhu Yang1, Dong-Xin Tang2,*(), Li Luo2, Feng-Xi Long1, Jing-Hui Wang2, Bing Yang1
1Guiyang College of TCM, Guiyang, Guizhou, China,
2The First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou, China.
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Highlights

The characteristics of Chinese medicine prescribed by Professor Liu Shangyi for the treatment of cancer patients with stomachache include the activation of blood circulation, removal of dampness, and alleviation of pain.

Editor’s Summary

The results of this study may provide guidance for the clinical treatment of cancer patients with stomachache.

Abstract

Objective: To analyze National Chinese Medicine Master Liu Shangyi’s prescription characteristics of clinical medicine for the treatment of cancer patients with stomachache. Methods: Data on prescriptions for cancer patients with stomachache between January 2014 and July 2016 were collected. The composing principles were analyzed by unsupervised data mining methods including Apriori algorithm in association rules and complex system entropy cluster. Results: Based on the analysis of 120 prescriptions, the frequency of each herb and association rules among the herbs were computed. Four core combinations and two new prescriptions were mined from the database. Compared to the before treatment, the clinical symptomatic grading of stomachache after treatment was lower (P < 0.001). Conclusion: Professor Liu has been successful in the treatment of cancer patients with stomachache by prescribing medication that aids in activating blood circulation, removing dampness, and alleviating pain.



Key wordsNational Chinese Medicine Master      Liu Shangyi      Tumor      Stomachache     
Published: 05 January 2018
Fund:  The National Natural Science Foundation Project Area Science Foundation (81460697), Guizhou Project of Modernization of Traditional Chinese Medicine Department (SY [2014] 3008-1), Graduate Workstation Plan of Guizhou Province (Department of Education) (JYSZ [2014] 018), Science and Technology Support Program of Guizhou Province (Social Development Research Department) (SY [2014] 3026), Key Disciplines of the Department of Education and Graduate Education Innovation Program (GZS [2016] 08)
Corresponding Authors: Tang Dong-Xin     E-mail: tangdongxin@sina.com
Cite this article:

Wen-Qi Huang, Zhu Yang, Dong-Xin Tang, Li Luo, Feng-Xi Long, Jing-Hui Wang, Bing Yang. Data mining analysis of Professor Liu Shangyi’s prescription characteristics in clinical medicine for the treatment of cancer patients with stomachache. Traditional Medicine Research, 2018, 3(1): 52-61. doi: 10.12032/TMR201809064

URL:

https://www.tmrjournals.com/tmr/EN/10.12032/TMR201809064     OR     https://www.tmrjournals.com/tmr/EN/Y2018/V3/I1/52

Symptom Mild (+) Moderate (++) Serious (+++)
Stomachache Mild stomachache, occasional stomachache, does not affect work Stomachache can be tolerated, frequent episodes, affects work and rest Stomach pain is hard to bear, continuous pain, painkillers often required for pain relief
Table 1 Symptomatic grading of stomachaches
Herbs Frequency
Ezhu (Rhizoma Curcumae) 120
Biejia (Carapax Trionycis) 120
Donglingcao (Rabdosia rubescens) 74
Huanglian (Rhizoma Coptidis) 48
Maozhuacao (Radix Ranunculi Ternati) 42
Wuzhuyu (Fructus Evodiae) 41
Chuanxiong (Rhizoma Ligustici Chuanxiong) 36
Muxiang (Radix Aucklandiae) 31
Tianjihuang (Hypericum japonicum Thunb) 27
Wugong (Scolopendra) 27
Yuzhu (Radix polygonati officinalis) 26
Shihu (Herba Dendrobii) 26
Yinchen (Herba Artemisiae Scopariae) 25
Lücao (Scandent hop) 25
Binlang (Semen Arecae) 25
Jinqiancao (Herba Lysimachiae) 24
Xuchangqing (Radix Cynanchi Paniculati) 23
Huangjing (Rhizoma polygonati) 21
Huangqin (Radix Scutellariae) 19
Liujinu (Artemisia anomala) 18
Danggui (Radix Angelicae Sinensis) 18
Hanliancao (Eclipta alba) 14
Nüzhenzi (Fructus Ligustri Lucidi) 14
Cangzhu (Rhizoma atractylodis) 13
Banxia (Rhizoma Pinelliae) 13
Houpu (Cortex Magnoliae Officinalis) 12
Jiangxiang (Lignum Dalbergiae Odoriferae) 12
Yujin (Radix curcumae) 11
Caodoukou (Semen Alpiniae Katsumadai) 10
Table 2 The Chinese herbs that were used more than 10 times
Figure 1 Network diagram: “Support” and “Confidence” were set to 30 and 0.6
Herb model Frequency
Ezhu (Rhizoma Curcumae), Biejia (Carapax Trionycis) 120
Donglingcao (Rabdosia rubescens), Ezhu (Rhizoma Curcumae) 74
Donglingcao (Rabdosia rubescens), Biejia (Carapax Trionycis) 74
Donglingcao (Rabdosia rubescens), Ezhu (Rhizoma Curcumae), Biejia (Carapax Trionycis) 74
Ezhu (Rhizoma Curcumae), Huanglian (Rhizoma Coptidis) 48
Huanglian (Rhizoma Coptidis), Biejia (Carapax Trionycis) 48
Ezhu (Rhizoma Curcumae), Huanglian (Rhizoma Coptidis), Biejia (Carapax Trionycis) 48
Ezhu (Rhizoma Curcumae), Maozhuacao (Radix Ranunculi Ternati) 42
Maozhuacao (Radix Ranunculi Ternati), Biejia (Carapax Trionycis) 42
Ezhu (Rhizoma Curcumae), Maozhuacao (Radix Ranunculi Ternati), Biejia (Carapax Trionycis) 42
Wuzhuyu (Fructus Evodiae), Ezhu (Rhizoma Curcumae) 41
Wuzhuyu (Fructus Evodiae), Biejia (Carapax Trionycis) 41
Wuzhuyu (Fructus Evodiae), Huanglian (Rhizoma Coptidis) 41
Wuzhuyu (Fructus Evodiae), Ezhu (Rhizoma Curcumae), Biejia (Carapax Trionycis) 41
Wuzhuyu (Fructus Evodiae), Ezhu (Rhizoma Curcumae), Huanglian (Rhizoma Coptidis) 41
Wuzhuyu (Fructus Evodiae), Huanglian (Rhizoma Coptidis), Biejia (Carapax Trionycis) 41
Wuzhuyu (Fructus Evodiae), Ezhu (Rhizoma Curcumae), Huanglian (Rhizoma Coptidis), Biejia (Carapax Trionycis) 41
Chuanxiong (Rhizoma Ligustici Chuanxiong), Ezhu (Rhizoma Curcumae) 36
Chuanxiong (Rhizoma Ligustici Chuanxiong), Biejia (Carapax Trionycis) 36
Chuanxiong (Rhizoma Ligustici Chuanxiong), Ezhu (Rhizoma Curcumae), Biejia (Carapax Trionycis) 36
Donglingcao (Rabdosia rubescens), Maozhuacao (Radix Ranunculi Ternati) 35
Donglingcao (Rabdosia rubescens), Maozhuacao (Radix Ranunculi Ternati), Ezhu (Rhizoma Curcumae) 35
Donglingcao (Rabdosia rubescens), Maozhuacao (Radix Ranunculi Ternati), Biejia (Carapax Trionycis) 35
Donglingcao (Rabdosia rubescens), Ezhu (Rhizoma Curcumae), Maozhuacao (Radix Ranunculi Ternati), Biejia (Carapax Trionycis) 35
Muxiang (Radix Aucklandiae), Ezhu (Rhizoma Curcumae) 31
Muxiang (Radix Aucklandiae), Biejia (Carapax Trionycis) 31
Muxiang (Radix Aucklandiae), Ezhu (Rhizoma Curcumae), Biejia (Carapax Trionycis) 31
Table 3 More than 31 of the use frequency of couplet medicines
Couplet Medicines Correlation Coefficient Couplet Medicines Correlation Coefficient
Donglingcao (Rabdosia rubescens),
Liujinu (Artemisia anomala)
0.04197 Tianjihuang (Hypericum japonicum Thunb), Caodoukou (Semen Alpiniae Katsumadai) 0.022318
Huangjing (Rhizoma polygonati),
Liujinu (Artemisia anomala)
0.031544 Huangjing (Rhizoma polygonati), Banxia (Rhizoma Pinelliae) 0.022194
Huanglian (Rhizoma Coptidis), Wulingzhi (Faeces Togopteri) 0.03141 Huangjing (Rhizoma polygonati),
Cangzhu (Rhizoma atractylodis)
0.022194
Jinqiancao (Herba Lysimachiae), Hanliancao (Eclipta alba) 0.030608 Huangqin (Radix Scutellariae),
Nüzhenzi (Fructus Ligustri Lucidi)
0.021511
Nüzhenzi (Fructus Ligustri Lucidi), Binlang (Semen Arecae) 0.029221 Huangqin (Radix Scutellariae),
Hanliancao (Eclipta alba)
0.021511
Huangjing (Rhizoma polygonati), Donglingcao (Rabdosia rubescens) 0.029189 Liujinu (Artemisia anomala), Tianjihuang (Hypericum japonicum Thunb) 0.02146
Nüzhenzi (Fructus Ligustri Lucidi), Gegen (Radix Puerariae) 0.028668 Shihu (Herba Dendrobii),
Caodoukou (Semen Alpiniae Katsumadai)
0.021376
Jinqiancao (Herba Lysimachiae), Liujinu (Artemisia anomala) 0.028092 Huangjing (Rhizoma polygonati), Binlang (Semen Arecae) 0.021304
Banxia (Rhizoma Pinelliae), Yinchen (Herba Artemisiae Scopariae) 0.026992 Donglingcao (Rabdosia rubescens), Yimucao (Herba Leonuri) 0.020703
Jinqiancao (Herba Lysimachiae), Jiangxiang (Lignum Dalbergiae Odoriferae) 0.025583 Shihu (Herba Dendrobii), Tianjihuang (Hypericum japonicum Thunb) 0.020702
Huangjing (Rhizoma polygonati), Chuanxiong (Rhizoma Ligustici Chuanxiong) 0.025116 Tianjihuang (Hypericum japonicum Thunb), Yuzhu (Radix polygonati officinalis) 0.020702
Nüzhenzi (Fructus Ligustri Lucidi), Tianjihuang (Hypericum japonicum Thunb) 0.024496 Jiangxiang (Lignum Dalbergiae Odoriferae), Tianjihuang (Hypericum japonicum Thunb) 0.020506
Tianjihuang (Hypericum japonicum Thunb), Hanliancao (Eclipta alba) 0.024496 Chuanxiong (Rhizoma Ligustici Chuanxiong), Baifupian (Radix Aconitilateralis Preparata) 0.020398
Donglingcao (Rabdosia rubescens), Baihuasheshecao (Herba Hedyotis) 0.02449 Chuanxiong (Rhizoma Ligustici Chuanxiong),
Zizhuye (Folium Callicarpae Macrophyllae)
0.020398
Wuzhuyu (Fructus Evodiae), Danggui (Radix Angelicae Sinensis) 0.024386 Huangjing (Rhizoma polygonati), Jiangxiang (Lignum Dalbergiae Odoriferae) 0.020383
Jiangxiang (Lignum Dalbergiae Odoriferae), Liujinu (Artemisia anomala) 0.023894 Huangjing (Rhizoma polygonati),
Houpu (Cortex Magnoliae Officinalis)
0.020383
Donglingcao (Rabdosia rubescens),
Shihu (Herba Dendrobii)
0.023038 Yujin (Radix curcumae),
Banzhilian (Herba Scutellariae Barbatae)
0.020269
Donglingcao (Rabdosia rubescens), Yuzhu (Radix polygonati officinalis) 0.023038 Yujin (Radix curcumae), Jiuxiangchong (Aspongopus) 0.020269
Wuzhuyu (Fructus Evodiae),
Huangqin (Radix Scutellariae)
0.02236
Table 4 Analysis of the correlation between Chinese herbs
NO. Core Combination
1 Jinqiancao (Herba Lysimachiae), Nüzhenzi (Fructus Ligustri Lucidi), Huanglian (Rhizoma Coptidis)
2 Tainma (Rhizoma Gastrodiae), Dannanxing (Rhizoma Arisaematis Cum Bile), Baifupian (Radix Aconitilateralis Preparata)
3 Huangqin (Radix Scutellariae), Danggui (Radix Angelicae Sinensis), Huanglian (Rhizoma Coptidis)
4 Zhebeimu (Bulbus Fritillariae Thunbergii), Zelan (Herba Lycopi), Baihe (Bulbus Lilii), Laifuzi (Semen Raphani)
Table 5 Core herb combinations ing
NO. New prescription
1 Jinqiancao (Herba Lysimachiae), Nüzhenzi (Fructus Ligustri Lucidi), Huanglian (Rhizoma Coptidis), Huangqin (Radix Scutellariae), Danggui (Radix Angelicae Sinensis)
2 Tainma (Rhizoma Gastrodiae), Dannanxing (Rhizoma Arisaematis Cum Bile), Baifupian (Radix Aconitilateralis Preparata), Zhebeimu (Bulbus Fritillariae Thunbergii), Zelan (Herba Lycopi), Baihe (Bulbus Lilii), Laifuzi (Semen Raphani)
Table 6 New prescriptions
No stomachache Mild ache
(+)
Moderate ache
(++)
Serious ache
(+++)
Z P
Before treatment 0 45 60 15 -10.613 P < 0.001
After treatment 72 35 13 0
Table 7 Clinical Symptomatic Grading of stomachache before and after treatment
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