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1Traditional Medicine Research  2019, Vol. 4 Issue (3): 131-139    DOI: 10.12032/TMR20190403113
Special Issue on Persian Medicine     
The potential role of grape (Vitis vinifera L.) in prevention of threatened abortion via immunomodulatory and anti-inflammatory abilities: a hypothesis
Malihe Tabarrai1, Mozhgan Mehriardestani2, Sharareh Hekmat2, Fatemeh Nejatbakhsh1, Fatemeh Moradi1,*()
1Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
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Highlights

This paper proposed a hypothesis that grape (Vitis vinifera L.) could control threatened abortion due to its immunomodulatory and anti-inflammatory, anti-oxidant, anti-contraction, hormonal and anti-stress activities.

Traditionality

According to the records of traditional Persian medicine literatures, Grape (Vitis vinifera L.) had the function of fetal protection. Grape and grape molasses could produce good blood humor, the basic substances and fluids found in human body. As mentioned in Makhzan al-Advieh (1670 A.D.-1749 A.D.) and Tohfat al-Momenin (16th century), the leaf extract of Grapevine could prevent abortion. Rhazes, a great scientist of the 9th century A.D., also poineted out that unripe grapes juice could fortify the stomach of pregnant women and prevent the fetus from abortion in Al-Hawi (854 A.D.-925 A.D.) .

Abstract

Threatened abortion is a common problem in early pregnancy. This early vaginal bleeding happens in about 25% of pregnant women. The medications including progesterone, uterine muscle relaxant or human chorionic gonadotropin have essential effects in developing pregnancy, but the clinical data are insufficient to prescribe them. In recent decades, medicinal herbs can help us to present new treatments. Grape (Vitis vinifera L.) can protect the fetus from the perspective of Persian medicine. So, we hypothesize about the salutary effects of grape in miscarriage prevention. We found five standard expected mechanisms of grape to prevent threatened abortion: immunomodulatory and anti-inflammatory, anti-oxidant, anti-contraction, hormonal and anti-stress activities. Grape reduces nitric oxide, prostaglandin E2, expression of nuclear factor κB and other pro-inflammatory cytokines like IL (Interleukin)-1β, IL-6, IL-8, and tumor necrosis factor-α. It also elevates anti-inflammatory mediators and expression of peroxisome proliferator-activated receptor-γ. Grape polyphenols have a crucial role in fetus protection with high antioxidant power and other functions such as prevention of stress-triggered abortion with proanthocyanidins, or hormonal effects and inhibition of uterine contractions with resveratrol. So according to these studies, grape probably has effects on the immune and endocrine factors involved in threatened miscarriage.



Key wordsVitis vinifera L.      Grape      Oxidation      Immunomodulation      Inflammation      Abortion      Persian medicine     
Published: 04 May 2019
Fund:  This study has been partially supported by Tehran University of Medical Sciences (Grant No. 95-04-86-33380).
Corresponding Authors: Moradi Fatemeh     E-mail: dfmoradi@gmail.com.
Cite this article:

Malihe Tabarrai, Mozhgan Mehriardestani, Sharareh Hekmat, Fatemeh Nejatbakhsh, Fatemeh Moradi. The potential role of grape (Vitis vinifera L.) in prevention of threatened abortion via immunomodulatory and anti-inflammatory abilities: a hypothesis. 1Traditional Medicine Research, 2019, 4(3): 131-139. doi: 10.12032/TMR20190403113

URL:

https://www.tmrjournals.com/tmr/EN/10.12032/TMR20190403113     OR     https://www.tmrjournals.com/tmr/EN/Y2019/V4/I3/131

Figure 1 Expected mechanisms of grape to prevent threatened abortion
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