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1Traditional Medicine Research  2019, Vol. 4 Issue (3): 111-117    DOI: 10.12032/TMR20190426117
Annual Advances     
Annual advances of traditional medicine toxicity in 2018
Shu-Li Mana,1, Gen-Bei Wangb,c,d,1, Chang-Xiao Liue, Wen-Yuan Gaob,*()
aState Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.
bTianjin Key Laboratory for Modern Drug Delivery and High Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China.
cTasly Academy, Tasly Holding Group Co., Ltd., No. 2 Pujihe East Road, Tasly TCM Garden, Beichen District, Tianjin 300410, China.
dState Key Laboratory of Core Technology in Innovative Chinese Medicine, Tasly Holding Group Co., Ltd., No. 2 Pujihe East Road, Tasly TCM Garden, Beichen District, Tianjin 300410, China.
eThe State Key Laboratories of Pharmacodynamics and Pharmacokinetics, Tianjin 300193, China.
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1. Liver and kidney are the mainly toxic target organs of traditional medicine.

2. Recently, zebrafish embryoes are popular to evaluate the safety of traditional medicine.

3. The safety assessment of Aconitum, Tripterygium, Strychnine, etc. is still hot issue.


This annual review summarized different analysis methods of toxicology research, common evaluated models, toxic target organs, toxic mechanisms, and popular research issues and herbs in 2018. China, India, USA and Morocco were ranked from the first to fourth important countries researching the toxicology of traditional medicine.


There were many researches concerning toxicology of traditional medicine (TM) and active natural products during the past 12 months. This annual toxicology review summarized different analysis methods of toxicology research, common evaluated models, toxic target organs, toxic mechanisms, and popular research issues and herbs in 2018. The emphasis was on hepatorenal toxicity induced by TM through cell apoptosis, metabolic disorder, oxidative stress, inflammatory damage, liver and renal fibrosis and even inducing carcinogenesis. Meanwhile, traditional herbs were listed in this review. Taken together, the herbs mentioned in this paper should be used with caution. Combination of TM, processing drugs, quality control and dose control can be used in the prevention of TM toxicology in the future.

Key wordsTraditional medicine      Natural product      Herb      Toxicity      Toxic target organs      Risk assessment      Safety evaluation     
Published: 04 May 2019
Corresponding Authors: Gao Wen-Yuan     E-mail:
About author: 1They are regarded as co-first authors and contributed equally to this work.
Cite this article:

Shu-Li Man, Gen-Bei Wang, Chang-Xiao Liu, Wen-Yuan Gao. Annual advances of traditional medicine toxicity in 2018. 1Traditional Medicine Research, 2019, 4(3): 111-117. doi: 10.12032/TMR20190426117

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Figure 1 Statistical analysis of annual publications on toxicological studies on traditional medicine by relative percentages on different countries and toxic target organs
Figure 2 Examples of gene mutations induced by aristolochic acid
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