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1Traditional Medicine Research  2019, Vol. 4 Issue (4): 205-212    DOI: 10.12032/TMR20190508119
Special Issue on Integrative Surgery     
Effects of Da-Cheng-Qi decoction on enteroparalysis and serum inflammatory cytokines in patients with severe acute pancreatitis
Xiao Wang1,*(), Guo-Hong Yang1, Chen-Xiao Wang1, Chun-Ying Li1, Min Guo1, Ming-Hao Liu1, Zhen-Jun Zeng1, Jun Ma2, Qin-Sheng Zhang3
1Department of Gastroenterology, First Affiliated Hospital of Henan Traditional Chinese Medicine University, Zhengzhou, Henan, China.
2Department of Gastroenterology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
3Department of Gastroenterology, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China.
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This study demonstrated that Chinese herbal formula Da-Cheng-Qi decoction combined with the conventional treatment could effectively decrease the serum levels of CCL2, CRP, and IL-8, relieve enteroparalysis, and shorten the duration of hospitalization in patients with severe acute pancreatitis


Da-Cheng-Qi decoction (DCQD) is a famous Chinese herbal formula that includes Radix et Rhizoma Rhei (Dahuang), Cortex Magnoliae Officinalis (Houpu), Fructus Aurantii Immaturus (Zhishi), and Natrii Sulfas (Mangxiao). The original record about DCQD can be traced back to the 3rd Century A.D. According to the description in Shanghan Lun, an ancient book of Chinese medicine published in Han Dynasty of China, DCQD had the effect of purging accumulation and clearing heat from the stomach and intestine.


Objective: The objective of this study was to investigate the effects of Da-Cheng-Qi decoction (DCQD) on enteroparalysis and levels of the serum inflammatory cytokines C-C motif chemokine ligand 2 (CCL2) and interleukin-8 (IL-8) in patients with severe acute pancreatitis (SAP). Methods: A total of 48 patients diagnosed with SAP who hospitalized in First Affiliated Hospital of Henan Traditional Chinese Medicine University from May 1, 2016 to May 30, 2018 were randomly assigned to the control or treatment groups. Patients in the control group (n = 22) received conventional treatment and those in the treatment group (n = 26) received conventional treatment as well as additional DCQD for 10 days. The duration of abdominal pain and distension, the time when bowel sounds returned to normal, changes in the levels of serum amylase, lipase, C-reactive protein (CRP), CCL2 and IL-8, as well as acute physiology and chronic health evaluation (APACHE) II scores of patients on days 1 and 10 were recorded and compared. Results: The duration of abdominal pain and distension, the time when bowel sounds returned to normal, the levels of blood amylase, lipase and CRP, and APACHE II scores of patients in the treatment group decreased significantly compared with those of patients in the control group. Though there were no statistical differences in serum CCL2 and IL-8 concentrations on day 1 between patients in these two groups, the levels of serum CCL2 and IL-8 in the treatment group were lower than those in the control group on day 10. Conclusion: DCQD may decrease the levels of CCL2, CRP, and IL-8 in patients with SAP, quickly relieve enteroparalysis, and shorten hospitalization duration.

Key wordsDa-Cheng-Qi decoction      Severe acute pancreatitis      CRP      CCL2      IL-8     
Published: 05 July 2019
Fund:  This work was supported by Research Grant from Henan Provincial Administration of Traditional Chinese Medicine (No.2016ZY2033), Funds for Creative Research Team of Henan Province, and Creative Research Team of Chinese medicine research of Henan Province.
Corresponding Authors: Xiao Wang   
Cite this article:

Xiao Wang, Guo-Hong Yang, Chen-Xiao Wang, Chun-Ying Li, Min Guo, Ming-Hao Liu, Zhen-Jun Zeng, Jun Ma, Qin-Sheng Zhang. Effects of Da-Cheng-Qi decoction on enteroparalysis and serum inflammatory cytokines in patients with severe acute pancreatitis. 1Traditional Medicine Research, 2019, 4(4): 205-212. doi: 10.12032/TMR20190508119


Baseline data Control group
(n = 22)
Treatment group
(n = 26)
Sex (M/F)
Age (year)
Pathogen [(n)%] Cholelithiasis
APACHE II score (mean ± SD)
Balthazar CT score (mean ± SD)
48.5 ± 9.2
9 (40.9)
6 (27.3)
5 (22.7)
2 (9.1)
10.3 ± 5.6
4.8 ± 1.3
49.4 ± 8.9
10 (38.5)
8 (30.8)
6 (23.1)
2 (7.7)
9.9 ± 5.2
4.7 ± 1.5
Table 1 Baseline data analysis
M/F, Male/female; SD, Standard deviation.
Clinical manifestation Control group
(n = 22)
Treatment group
(n = 26)
Abdominal pain
Abdominal distension
Bowel sounds return
5.45 ± 2.27
5.12 ± 2.41
5.15 ± 2.17
3.81 ± 1.94
3.79 ± 1.93
3.67 ± 1.86
Table 2 The days of abdominal pain, abdominal distension and bowel sounds return to normal
Figure 1 Effects of DCQD on APACHE II score and CRP level
DCQD, Da-Cheng-Qi decoction; APACHE II, Acute physiology and chronic health evaluation II; CRP, C-reactive protein.
Figure 2 Effects of DCQD on the levels of amylase and lipase
DCQD, Da-Cheng-Qi decoction.
Figure 3 Effects of DCQD on the levels of CCL2 and IL-8
CL2, C-C motif chemokine ligand 2; IL-8, Interleukin-8; DCQD, Da-Cheng-Qi decoction.
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