Please wait a minute...
1Traditional Medicine Research  2019, Vol. 4 Issue (4): 213-221    DOI: 10.12032/TMR20190622123
Special Issue on Integrative Surgery     
Artificial tiger bone powder for improving the quality of life in elderly patients with fracture
Li-You Wei1, Hong-Wei Zhang1,*(), Jin-Zeng Zuo1, Su-Miao Xu2
1The Second Hospital of Tangshan (Orthopaedic Hospital Affiliated to North China University of Science and Technology), Tangshan, 063000, China.
2Tangjiazhuang Hospital of Kailuan (Group) Limited Liability Corporation, Tangshan, 063000, China.
Download: HTML     PDF(1824KB)
Export: BibTeX | EndNote (RIS)      

Highlights

The early administration of artificial tiger bone powder after distal radius fracture promotes the healing of fracture, recovery of wrist joint function, and ultimately improve the quality of life in elderly patients.

Traditionality

Tiger bone has been used as a rare traditional medicinal product in ancient Chinese pharmacopoeia for hundreds of years. The earliest record about the usage of tiger bones as a medicine is in the ancient book of Chinese medicine Ming Yi Bie Lu published in Han Dynasty of China (184 C.E.- 220 C.E.). After that, there were many traditional Chinese medicine ancient books recorded that tiger bone had the effect of analgesia, eliminating wind to dispersing cold and strengthening bone. Presently, however, tiger bone use has been banned internationally and in China as a protected species. The artificial tiger bone powder is extracted from non-protected animal bones by modern bionic technology, and has almost the same composition as natural tiger bone.

Abstract

Objective: To investigate the application of artificial tiger bone powder on fracture healing time, wrist functional recovery and quality of life (QOL) in elderly patients with distal radius fracture. Methods: The study was a randomised controlled trials performed from January 2015 to December 2016 in a hospital. Elderly patients with distal radius fracture were divided into the treatment and the control groups by the random sealed envelope method. All patients were given splint or plaster fixation after manipulative reduction, and functional exercise, the treatment group was also given artificial tiger bone powder orally (trade name: Jintiange capsule), the control group was given an oral placebo in their appearance and usage identical with the treatment group. Prior to treatment and 6, 12 months after treatment, the wrist function was assessed by range of motion, including flexion-extension, radial-ulnar and pronation-supination, and the QOL was assessed by the Mos 36-item Short Form Health Survey. Each patient's fracture healing time was recorded. Results: Before treatment, there were no significant differences in wrist function and QOL between the two groups. At 6 and 12 months after treatment, the wrist function and QOL in the treatment group were better than those in the control group, the differences were statistically significant (P < 0.05). The fracture healing time in the treatment group was shorter than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion: The early usage of artificial tiger bone powder for elderly patients with distal radius fracture can promote the healing of fracture, recovery of wrist joint function, and ultimately improve the QOL for elderly patients.



Key wordsArtificial tiger bone powder      Elderly people      Distal radius fracture      Wrist function      Quality of life     
Published: 05 July 2019
Fund:  This work was supported by Science and Technology Support Project of Hebei Traditional Chinese Medicine Administration (No. 2019210).
Corresponding Authors: Hong-Wei Zhang   
E-mail: zhanghw200087@163.com
Cite this article:

Li-You Wei, Hong-Wei Zhang, Jin-Zeng Zuo, Su-Miao Xu. Artificial tiger bone powder for improving the quality of life in elderly patients with fracture. 1Traditional Medicine Research, 2019, 4(4): 213-221. doi: 10.12032/TMR20190622123

URL:

https://www.tmrjournals.com/tmr/EN/10.12032/TMR20190622123

Figure 1 Flow diagram of this randomized controlled trials
Group Gender
(cases)
Age
(years)
Side
(cases)
AO-type
(cases)
Flexion
(cases)
Cause
(cases)
Fracture healing time
(weeks)
M/F L/R A/B/C Plaster/splint Fall/traffic/other
Control (n = 38) 12/26 69.16 ± 4.56 17/21 6/13/19 11/27 32/4/2 12.82 ± 1.51
Treatment (n = 38) 15/23 68.64 ± 4.52 20/18 7/15/16 13/25 34/3/1 11.47 ± 1.68
x2 /t/ Z, P value x2 = 0.517 t = 0.425 x2 = 0.474 Z = -0.649 x2 = 0.244 x2 = 0.537 t = 3.473
P = 0.472 P = 0.673 P = 0.491 P = 0.516 P = 0.622 P = 0.765 P < 0.001
Table 1 Baseline demographics and fracture healing time
Note: M/F: Male/Female; L/R: Left/Right; AO-type: Arbeitsgemeinschaft für Osteosynthesefragen type; A: Extra articular fractures; B: Partial intra-articular fractures; C: Complete intra-articular fracture.
Figure 2 Comparison of wrist ROM
A: Flexion-extension; B: Radial-ulnar; C: Pronation-supination. Unit of wrist ROM is showed as percentage (%)
Figure 3 Comparison of SF-36
Unit of project of SF-36 is score. PF: Physical functioning; RP: Role limitations due to physical health problems; BP: Bodily pain; GH: General health; VT: Vitality; SF: Social functioning; RE: Role limitations caused by emotional problems; MH: Mental health.
1.   Hanel DP, Jones MD, Trumble TE.Treatment of Complex fractures wrist fractares. Orthop Clin North Am 2002, 33: 35-38.
doi: 10.1016/S0030-5898(03)00071-3
2.   Wei LY, Li ZM, Zhang WF, et a1. Plintlet versus locking plate for treating intra-articular distal radius fracture in the elderly. Orthop J China2017, 25: 2238-2243. (Chinese)
3.   Wei LY, Zhang HW, Zhao G. Sodium aescinate gel alleviates hand swelling in elderly patients with distal radius fracture. Chin J Gen Pract2016, 15: 789-791. (Chinese)
4.   Zhang W, Wang B. Treatment options of unstable distal radial fractures in elderly patients. Chin J Geriatr2012, 19: 563-565. (Chinese)
5.   Cowell F, Gillespie S, Cheung G, et al. Complex regional pain syndrome in distal radius fractures: How to implement changes to reduce incidence and facilitate early management. J Hand Ther 2018, 31: 201-205
doi: 10.1016/j.jht.2018.01.013
6.   Javed S, Shahid R, Thimmiah R, et a1. Volar locking plate osteosynthesis for distal radial fractures. J Orthop Surg (Hong Kong) 2015, 23: 323-326.
doi: 10.1177/230949901502300313
7.   Herzberg G, Burnier M, Marc A, et a1. Primary wrist hemiarthroplasty for irreparable distal radius fracture in the independent elderly. J Wrist Surg 2015, 4: 156-63.
doi: 10.1055/s-00000183
8.   Nelson GN, Stepan JG, Osei DA, et a1. The impact of patient activity level on wrist disability after distal radius malunion in older adults. J Orthop Trauma 2015, 29: 195-200.
9.   Kou YH, Wang TB, Deng L, et a1 .The effect of artificial tiger bone on fracture healing in rats. Chin J Osteoporos2011, 17: 605-616. (Chinese)
10.   Fan YM, Li RF. Effect of artificial Tiger bone powder on Retinoic Acid-induced Osteoporosis in Rat. Pharm Clin Chin Materia Medica2001, 17: 13-14. (Chinese)
11.   Wu GB, Xu WJ, Yang B. Effect of Jintiange capsule on bone healing in osteoporotic fracture of surgical neck of the humerus. Chin J Osteoporos2011, 17: 64-66. (Chinese)
12.   Liao YQ, Yang K, He MW, et a1. Clinical observation for the treatment of osteoporotic femoral intertrochanteric fracture with DHS combined with Jintiange capsule. Chin J Osteoporos2011, 17: 523-525. (Chinese)
13.   Brink PRG, Bransz N, Deijkers RLM, et al. Guideline distal radius fractures, Diagnosis and treatment 2010.
14.   Kwasny O, Fuchs M, Hertz H, et a1. Skeletal transfixation in treatment of comminuted fractures of the distal end of the radius in the elderly. J Trauma 1990, 30: 1278-1284.
doi: 10.1097/00005373-199010000-00014
15.   Reissner L, Fischer G, List R, et a1. Minimal detectable difference of the finger and wrist range of motion: comparison of goniometry and 3D motion analysis. J Orthop Surg Res 2019, 14: 173.
doi: 10.1186/s13018-019-1177-y
16.   Golec P, Depukat P, Rutowicz B, et a1. Main health-related quality-of-life issues in patients after a distal radius fracture. Folia Med Cracov 2015, 55: 23-32.
17.   Alexiou KI, Roushias A, Varitimidis SE, et al. Quality of life and psychological consequences in elderly patients after a hip fracture: a review. Clin Interv Aging 2018, 13: 143-150.
doi: 10.2147/CIA
18.   Schmitz P, Lüdeck S, Baumann F, et al.Patient-related quality of life after pelvic ring fractures in elderly. Int Orthop 2019, 43: 261-267.
doi: 10.1007/s00264-018-4030-8
19.   Corrales LA, Morshed S, Bhandari M, et al.Variability in the assessment of fracture-healing in orthopaedic trauma studies. J Bone & Joint Surg 2008, 90: 1862-1868
20.   Safdari M, Koohestani MM.Comparing the effect of volar plate fixators and external fixators on outcome of patients with intra-articular distal radius fractures: A clinical trial. Electron Physician 2015, 7: 1085-1091.
21.   Giwa L, Spacey K, Packer G.Management of a Complex, Multioperated Intra-Articular Distal Radius Fracture. J Wrist Surg 2015, 4: 179-182.
doi: 10.1055/s-00000183
22.   Bartl C, Stengel D, Bruckner T, et a1. The treatment of displaced intra-articular distal radius fractures in elderly patients. Dtsch Arztebl Int 2014, 111: 779-787.
23.   Richard MJ, Katolik L, Hanel DP, et a1. Distraction plating for the treatment of highly comminuted distal radius fractures in elderly patients. J Hand Surg Am 2012, 37: 948-956.
doi: 10.1016/j.jhsa.2012.02.034
24.   Karantana A, Scammell BE, Davis TR, et a1. Cost-effectiveness of volar locking plate versus percutaneous fixation for distal radial fractures: Economic evaluation alongside a randomised clinical trial. Bone Joint J 2015, 97: 1264-1270.
doi: 10.2106/JBJS.N.01247
25.   Lutz K, Yeoh KM, MacDermid JC, et a1. Complications associated with operative versus nonsurgical treatment of distal radius fractures in patients aged 65 years and older. J Hand Surg Am 2014, 39: 1280-1286.
doi: 10.1016/j.jhsa.2014.04.018
26.   Zhang YS. The effect of Jintiange Capsule on retinoic acid induced rat osteoporosis. Chin Remedies & Clinics2007, 9: 688-689. (Chinese)
27.   Zhang WR, Lu J, Song DH, et a1. Effects of Jintiange capsules in treating fracture healing and in microstructure of bone in rats, Tianjin J Tradit Chin Med2015, 32: 286-290. (Chinese)
28.   Yeoh JC, Pike JM, Slobogean GP, et a1. Role of Depression in Outcomes of Low-Energy Distal Radius Fractures in Patients Older Than 55 Years. J Orthop Trauma 2016, 30: 228-233.
doi: 10.1097/BOT.0000000000000514
29.   Peeters CM, Visser E, Van de Ree CL, et a1. Quality of life after hip fracture in the elderly: A systematic literature review. Injury 2016, 47: 1369-1382.
doi: 10.1016/j.injury.2016.04.018
[1] Wen-Qi Huang, Zhu Yang, Dong-Xin Tang, Feng-Xi Long, Li Luo, Bing Yang, Juan Li, Jie Chen. Pharmacological intervention of traditional Chinese medicine for the quality of life in patients with colorectal cancer: a systematic review and meta-analysis[J]. 1Traditional Medicine Research, 2018, 3(2): 95-105.
[2] Liu Ji-Ye, Chen Ying-Hua. Effects of acupuncture treatment for irritable bowel syndrome: a systematic review and meta-analysis[J]. 1Traditional Medicine Research, 2016, 1(4): 183-194.