1Traditional Medicine Research
is an international peer-reviewed, Open Access journal. It is dedicated to report the research progress in clinical efficacy, action mechanism and theoretical research on traditional medicine, including traditional Chinese medicine, traditional Indian medicine, Persian medicine and other traditional medicine around the world. In addition to the editorial, review, basic research and clinical research, letters, news and comment, the following topics are also welcome: comparative research, academic hypothesis, methodological research, traditional literature research, annual advances, standard and guideline. Researches of traditional medicine which have definite historical records, ethnic feature, and regional distribution are welcome especially. In order to focus on breakthrough research in a field, TMR insist on publishing special issues around a topic related to traditional medicine.
Compared with donepezil, the long-term treatment of kidney-nourishing (The the change of pathological state of kidney deficiency by means of traditional Chinese medicine (TCM) treatment and so on) formula in TCM can significantly improve the Alzheimer's disease assessment scale-cognitive subscale score and the activities of daily living score.
The description of dementia-related symptoms can be found in historical book entitled Zuo Zhuan (The Spring and Autumn Annals) (722 B.C.E.-–468 B.C.E.) in the Pre-Qin Dynasty, and the name of Chidai was first proposed by Sun Simiao in Huatuo Shenyi Mizhuan (Biography of Hua Tuo's Medicine) (618 B.C.E.-–907 C.E.), a Chinese medicine classical book published in the Tang Dynasty. The Chinese medicine classical book entitled Huangdi Neijing (The Yellow Emperor's Internal Classic) (221 B.C.E.-–220 C.E.) provides a theoretical basis for establishing a link between kidney and dementia. Therefore, nourishing kidney (the changes of pathological state of kidney deficiency by means of TCM treatment and so on) has become an important treatment for dementia by TCM clinicians nowadays.
Objective: Finding an effective therapy against Alzheimer’s disease (AD) has been associate increasingly pressing issue and traditional Chinese medicine (TCM) is widespread in the prevention and treatment of AD in China. The aim of this study was to judge the efficaciousness and safety of TCM kidney-nourishing (the changes of pathological state of kidney deficiency by means of TCM treatment and so on) formula (TKNF) for AD in comparison with donepezil. Methods: The retrieval period of seven databases was from the establishment of each database to April 2019. Two authors independently identified randomized controlled trials (RCTs), fetched data and assessed bias risk. Comprehensive analysis process was conducted with review manager for eligible and appropriate RCTs. Results: A complete of 981 AD patients from 13 studies were enclosed. Meta-analysis of RCTs showed that there was no significant difference in the improvement of Alzheimer's disease assessment scale-cognitive subscale score between 2 groups in short term, but the effect of long-term treatment may exceed donepezil; there was a significant difference in the improvement of activities of daily living score between 2 groups; there was a significant difference in TCM curative efficacy between 2 groups with long-term treatment. There was no significant difference in the incidence of adverse events between 2 groups. The quality of the evidence was high or moderate. Conclusion: Compared with donepezil, TKNF was an effective drug for AD patients and the clinical application of TKNF was safe. TKNF's long-term benefits need more evidence to verify.
Fei-Zhou Li, Yi-Ni Zhang, Tong Zhang, Ling Liu, Ping Wang
Kaempferol and quercetin are found to be the two main compounds of classical prescription of traditional Chinese medicine named Danggui Buxue decoction with the highest network regulation, which can inhibit the transformation of fibroblasts into myofibroblasts and reduce the expression of fibrosis markers α-smooth muscle actin, collagen 1, fibronectin.
decoction (DBD), a classical prescription in traditional Chinese medicine composed
of Huangqi (Radix Astragali) and Danggui (Radix Angelicae Sinensis)
in a ratio of 5:1, originates from the Chinese medicine ancient book entitled
Neiwai Shangbian Huolun written by the famous medical scientist Li Dongyuan in
1247 C.E. At present, there are many researchers who try to study the
biological activity of individual chemical components in DBD and the mechanism
of action of whole formula. Some studies have shown that DBD has effect on
fibrosis of heart, liver and kidney and has protective effect on
bleomycin-induced pulmonary fibrosis in rats by reducing alveolar inflammation
Backgroud: Danggui Buxue decoction
(DBD), a classical prescription in traditional Chinese medicine, has been found
to have protective effect on bleomycin-induced pulmonary fibrosis in rats by
reducing alveolar inflammation and fibrosis. However, the biological activity
of individual chemical components and mechanism of action of whole formula are
not clear. Methods: Potential targets of active ingredients of DBD were
collected through Traditional Chinese Medicine Systems Pharmacology Database
and Analysis Platform and SymMap database. Target genes related to idiopathic
pulmonary fibrosis were obtained from the Online Mendelian Inheritance in Man database,
Therapeutic Targets Database and Gkb database. Then, the common targets were
obtained by overlapping the potential targets of active ingredients in DBD and
diseases related targets. The selected targets were subjected to Kyoto
Encyclopedia of Genes and Genomes signaling pathway and Gene Ontology analysis,
and the network map of active component-target-pathway was established using
Cytoscape 3.7.1 software. The active components of DBD with most targets were
selected for fibrosis-related marker verification. The mRNA and protein
expression of fibrosis markers, α-smooth muscle actin, collagen 1 and
fibronectin, were detected in TGF-β1-induced fibroblast cell line after
treatment with the active components. Results: The 14 active
ingredients, such as quercetin and kaempferol, were screened from DBD. It acts
on 26 targets like estrogen receptor 2 and prostaglandin-endoperoxide synthase 2, and mainly involves 38
signaling pathways such as cell inflammation and autophagy. Kaempferol and
quercetin are the two compounds with the highest network regulation, which can
inhibit the transformation of fibroblasts into myofibroblasts and reduce the
expression of fibrosis markers α-smooth muscle actin, collagen 1 and
fibronectin. Conclusion: The integration mode of multi-component,
multi-target, multi-channel and mechanism of DBD in the treatment of idiopathic
pulmonary fibrosis are predicted by means of network pharmacology. Our study
could indicate the direction of further anti-fibrotic mechanism research.
Cai-Ping Zhao, Hang Li, Xiao-Hong Liu, Shuang Liang, Xue-Lei Liu, Xin-Rong Li, Yi Luo, Mei-Ling Zhu
According to a message posted by the official Weibo account of Chengguan Sub-bureau of the Lanzhou Public Security Bureau in Gansu Province of China, on the morning of October 22, 2019, a suspect named Yang (male, aged 54 years, a native of Lanzhou City of Gansu Province) attacked a doctor Feng (female, aged 42 years, a native of Lanzhou City) with a knife at Gansu Provincial Hospital. Unfortunately, despite all efforts to rescue her, Feng passed away. After the incident, Public Security Institutions immediately took control of suspect Yang. According to the preliminary investigation, Yang once underwent a surgery for rectal cancer at Gansu Provincial Hospital, in which Doctor Feng was his attending physician. The case is currently under further investigation .
History book entitled Shi Ji (the Grand Historian) combines the biographies of famous doctors Bian Que and Chunyu Yi into the Bian Que Cang Gong Lie Zhuan (Biography of Bian Que and Cang Gong) . According to the record of Shi Ji, as early as in the Zhou Dynasty (1046-256 B.C.E.) of China, Bian Que (407-310 B.C.E.) died from murder. When the chief physician of Qin State Li Xi—learned that his medical skills were not as good as Bian Que’s, he sent an assassin to kill him.
On September 27, 2019,
the Palace Museum and China Academy of Chinese Medical Sciences held a signing
ceremony of strategic cooperation at Jingsheng Zhai (The studio of esteemed
excellence) in the garden of Jianfu Gong (The palace of established happiness)
at the Palace Museum.
This cooperation will focus on the vast collection of cultural
relics on traditional Chinese medicine (TCM) in the Palace Museum and
represents a joint venture into the scientific study of TCM cultural relics
from the court of the Qing dynasty of China (1636 C.E.-1912 C.E.) .
Tai Yi Ling (Chief imperial physician) was recorded in the Records
of Shiji (the Grand Historian) (Figure 1a) [2, 3]. The famous doctor Bian Que died in 310 B.C.E, who’s exact death
details are unclear until now. But there is a thought that he was assassinated
by Li Xi, who was a chief imperial physician in the state of Qin, and the
reason of the murder was jealousy  .
The name of the Tai Yi Yuan (Imperial medical academy)
originated from the Jin dynasty of China (1115 C.E.-1234 C.E.), and was
inherited from the Tai Yi Shu (Imperial medical office) and Tai Yi Ju (Imperial medical bureau) of the Tang (618 C.E.-907 C.E.) and Song dynasties of
China (960 C.E.-1279 C.E.). Between 1078 C.E. and 1085 C.E. of the Song
dynasty, the imperial medical bureau collated and published its formula
blueprints under the title Taiyiju Fang (Formulary of the imperial medical
bureau). After several rounds of revision and supplementation, the text was
eventually finalized after final additions were made between 1225 C.E. and 1227
C.E. as well as 1241 C.E. and 1252 C.E., becoming the current popularized
version known as Taiping Huimin Hejiju Fang (Formulary to benefit the
people from the pharmaceutical
bureau of the Taiping reign) (Figure
1b) . The medical classics named Yuyaoyuan Fang (Formulary of
the imperial pharmacy) of the Yuan dynasty (1279 C.E.-1368 C.E.) was revised
and edited by Xu Guozhen and others using Yuyaoyuan Fang (Formulary of
the imperial pharmacy) (Figure 1c) of the Jin dynasty as base text. It was finalized in 1267 C.E. and
is an important material for studying the medical formulae of the courts of the
Jin and Yuan dynasties (1271
C.E.-1368 C.E.) .
Imperial medical academies
were established in all subsequent dynasties . The Imperial medical
academy of the Ming dynasty of China (1368 C.E.-1644 C.E.) was a central
institution that managed the diagnosis and pharmacy services of the court and
nobility . Li Shizhen, a famous medical scientist in
ancient China, was appointed an official at the imperial medical academy in
Beijing at 27 years old. In 1549 C.E., the 28th year of Jiajing emperor
of the Ming dyansty, Li Shizhen resigned from his position at the imperial medical
academy at the age of 32 and returned to Ganzhou city of China. He wrote the
medical classics named Bencao Gangmu (Compendium of materia medica) in
his later years (Figure 1d) .