1Traditional Medicine Research
is an international peer-reviewed, Open Access journal. It is dedicated to report the research progress in clinical efficacy, action mechanism and theoretical research on traditional medicine, including traditional Chinese medicine, traditional Indian medicine, Persian medicine, regional medicine, minority medicine and other traditional medicine research around the world. In addition to the editorial, review, basic research and clinical research, letters, news and comment, the following topics are also welcome: comparative research, academic hypothesis, methodological research, traditional literature research, annual advances, standard and guideline. Researches of traditional medicine which have definite historical records, ethnic feature, and regional distribution are welcome especially. In order to focus on breakthrough research in a field, TMR insist on publishing special issues around a topic related to traditional medicine.
The identification of syndrome conditions had different impacts on CRC prognosis, and which may be related with different mRNA expression levels. Our results prelimitarily uncovered that some oncogenes and pro-inflammatory cytokines were highly expressed in Dampness Heat group but not other syndrome types and CRC patients with Dampness Heat syndrome may might have a poor prognosis.
TCM Syndrome syndrome is a kind of pathological profiles that reflect signs and symptoms at a certain stage of a disease, which is the most essential guidelines for the prescription of Chinese herbal formulae and also an important classification for CRC TCM therapy. A clear understanding biological basis of TCM syndrome will help the clinical diagnosis and the treatment for CRC patients hopefully.
Background: Traditional Chinese medicine (TCM) syndrome, also named syndrome, are comprehensive and integral analyses of clinical information which helps to guide different individualized treatment prescriptions. Methods: Thirty healthy controls and 80 colorectal cancer (CRC) patients (including 33 Spleen Qi Deficiency syndrome, 23 Dampness heat Heat syndrome, 17 Blood stasis Stasis syndrome and 7 other syndrome) were enrolled into this study. Human mRNAs were extracted from peripheral blood mononuclear cells. The gene expression for CRC patients with different TCM syndrome was determined by microarray and qRT-PCR. Results: Spleen Qi Deficiency, Dampness Heat and Blood Stasis were the most common syndromes in CRC patients. There is a significant difference was found in mRNA expression levels (especially for PIK3CA, STAT3, SOX9 and KDM5C) among Spleen Qi Deficiency, Dampness Heat and Blood Stasis syndrome groups. The higher mRNA levels of JNK1, TP53, MLH1, MSH6, PMS2, SOCS3, TCF7L2, FAM123B, PSAP, FBXW7, SALL4 and the lower expression of inflammatory cytokine IL-6 were found in Spleen Qi Deficiency group but not other syndrome types. The higher mRNA levels of KRAS, MUC16, EGFR, GRASP65, PIK3CA, MAPK7, CD24, STAT3, SLC11A1, Bcl-2, TXNDC17 and some inflammatory cytokines (IL-6, IL-23, TNF-a, CXCR4) were found in Dampness Heat group but not other syndrome types. Blood Stasis syndrome showed higher expression of SOX9, MLH1, MSH6, KDM5C, PCDH11X, PSAP and SALL4, and lower mRNA levels of PIK3CA, CD24, STAT3, CXCR4, TXNDC17 and TP53. The CRC patients with Dampness Heat syndrome may might have a poor prognosis than other syndrome types. Conclusion: The identification of syndrome conditions had different impacts on CRC prognosis, and which may might be related with different mRNA expression levels. Some oncogenes and pro-inflammatory cytokines were highly expressed in Dampness Heat group but not other syndrome types, suggesting that the CRC patients with Dampness Heat syndrome may might have a poor prognosis. Our results prelimitarily uncovered the molecular basis of syndrome differences in CRC prognosis, a better understanding for TCM treatment of CRC.
This manuscript categorizes and concludes research results on the correlation between different natural products and pyroptosis in recent years.
The present review summarizes many natural products coming from traditional Chinese medicine that play the role in regulating pyroptosis, such as Chuanxinlian [Andrographis paniculata (Burm. f.) Nees.], Gancao (Glycyrrhiza uralensis Fisch.), Huanglian (Coptis chinensis Franch.), Tusizi (Cuscuta chinensis Lam.), Heizhima (Sesamum indicum L.), etc. The first record about Gancao (Glycyrrhiza uralensis Fisch.) and Huanglian (Coptis chinensis Franch) is in the ancient book of Chinese medicine named Shennongbencaojing (Donghan dynasty of China).
In recent years, large numbers of novel cell death types have been reported such as autophagic death, paraptosis, mitosis, oncosis and pyroptosis. As a new type of proinflammatory programmed cell death, pyroptosis has attracted increasing attentions gradually, and its morphological characteristics and molecular mechanisms are significantly different from other cell death types such as necrosis and apoptosis. Many research groups have demonstrated the association between pyroptosis and various human diseases including immunological disease, cancer, atherosclerosis, infectious disease, and cardiovascular and cerebrovascular disease. Natural products are small molecules synthetized in organisms including primary and secondary metabolites. Natural products are important sources of modern innovative drugs discovery and can be used as key tools to explore the molecular mechanism of cell fate. The aim of this study is to review the molecular mechanisms and pathways of pyroptosis, and to categorize and conclude research results on the correlation between different natural products and pyroptosis in recent years. In this study, a total of 39 papers were enrolled in analyses. The molecular pathways and mechanisms of pyroptosis were clearly described. Fourteen types of natural products, their sources, effects, mechanisms and therapeutic potentials are categorized and illuminated. It is showed that a variety of natural products and pyroptosis have close correlations. They negatively or positively affect or act on different positions of pyroptosis inflammatory pathways, indicating that they may have certain potential therapeutic effects on pyroptosis-related diseases. Pyroptosis, a relatively new way of cell death, is closely associated with a variety of diseases. Natural products can have obvious effects on the process of pyroptosis as potential sources of new drugs. In-depth studies using natural products to investigate pyroptosis will help to enhance our understandings of human diseases and establish effective prevention and treatment strategies.
Wound healing impairment and ulcers in the foot, with pain and disability, are common complications of diabetes. The present case report shows the effectiveness of leech therapy in combination with honey and curcumin dressing on disease progression in a patient with diabetic foot ulcer.
In Iranian traditional medicine, leeches are used to treat many diseases. Natural honey and curcumin are available for dressing all types of ulcers. Hakim Aghili reported several operative properties that make them appropriate for wounds. Medicinal leech therapy was first documented in a painting of an Egyptian tomb in 1500 B.C.E. Subsequently, the use of leech therapy for medicinal purposes increased dramatically in the 17th and 18th centuries in Europe and Asia. In 1960s, leeches were used in reconstructive surgery to eliminate intravenous congestion. In 1970s, leech therapy was used only in microsurgeries. The Food and Drug Administration legalized medicinal leech therapy in 2004.
Background: Diabetic foot ulcers (DFUs) are common in patients with diabetes. The mortality rate of DFUs is ranked the highest after cancer. With advancements in modern medicine, leech therapy, a traditional treatment method for chronic wounds in Iranian medicine, has proven effective in relieving venous congestion. Herein, we aimed to observe the curative effects of leech therapy in combination with honey and curcumin dressing in a 77-year-old patient with a diabetic foot ulcer (UFC). Methods: Two medium-sized medicinal leeches were placed surrounding a grade 2 wound, based on Wagner’s classification system, located on the right first toe. The patient reported a visual analogue scale (VAS) score of 8. After leech therapy, the wound was covered with honey and curcumin, followed by oral administration of ciprofloxacin for 10 days. Results: Pain increased immediately after leech therapy (VAS: 9-10) but decreased significantly (VAS: 6) 2 days after the therapy. At the end of the 2nd day, pain completely disappeared. After 3 weeks, there was no wound on the toe. After 12 weeks, there were no traces of the wound. Conclusion: Leech therapy in combination with honey and curcumin dressing is effective against disease progression in patients with DFUs.
(1) The use of complementary and alternative medicine (CAM) is growing rapidly especially among
younger female patients with cancer with higher education.
(2) Most patients with cancer consider CAM as a harmless option in their healing process, which is not
always the case.
(3) Clinical-based evidence for mind-body therapies has been established, and this type of CAM can be
recommended for patients with cancer during chemotherapy.
The use of complementary and alternative medicine (CAM) plays an important role in the prevention and treatment of diseases since the ancient times. In the 16th-11th century B.C.E., there were earliest notes of tumors and their treatment methods were described by traditional Chinese practitioners. It has been known that herbal medicine are used in Egypt and in traditional Chinese medicine since 4500 B.C.E. Since the early 1970s, the use of CAM in cancer treatment has expanded worldwide. Numerous studies point to the benefits of Ayurveda yoga in patients with cancer, improving quality of life. China acupuncture has been shown beneficial in controlling vomiting and pain in patients with cancer. Reflexology, which was practiced for years by followers of Chinese, Egyptian, and Indian medicine, has been successfully used to relieve pain in patients with cancer. Mushroom Agaricus blazei has been mostly used in Japan but is currently in the first phase of the clinical trial in patients with cancer.
Besides conventional medicine, many patients with cancer seek complementary and alternative medicine (CAM) as an additional treatment option. Since the early 1970s, the use of CAM in cancer treatment has expanded worldwide. CAM, as a tempting option, was used by patients with cancer mainly due to easy accessibility. Patients with cancer used CAM to achieve better quality of life or to find a cure. As physicians are mainly unaware of CAM use by patients, doctor-patient communication about CAM use should be brought to a higher level. To identify circumstances in which CAM are preferred, further investigations are needed especially in biologically based therapies. Clinical-based evidence for mind-body therapies have been established, so this type of CAM can be recommended for patients with cancer during chemotherapy. Future studies are necessary to fill the gaps so that CAM users, as well as medical experts, are in position to clearly determine all the benefits and disadvantages of the mentioned therapy.