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The Official Journal of China Anti-Cancer Association
Editor-in-Chief: XZ Wu, PhD
ISSN 2413-3973
1Traditional Medicine Research is an international peer-reviewed, Open Access journal. It is dedicated to report the research progress in clinical efficacy, action mechanism and theoretical research on traditional medicine, including traditional Chinese medicine, traditional Indian medicine, Persian medicine and other traditional medicine around the world. In addition to the editorial, review, basic research and clinical research, letters, news and comment, the following topics are also welcome: comparative research, academic hypothesis, methodological research, traditional literature research, annual advances, standard and guideline. Researches of traditional medicine which have definite historical records, ethnic feature, and regional distribution are welcome especially. In order to focus on breakthrough research in a field, TMR insist on publishing special issues around a topic related to traditional medicine. ... More

Traditional Medical Systems More

Traditional Therapies More


Acupuncture

Moxibustion

Cupping

Exercise Therapy

Food Therapy

Traditional Literatures More

Third century · Shang Han Lun
Third century · Jin Gui Yao Lue
284 A.D-354 A.D. · Zhou Hou Bei Ji Fang
652 A.D. · Qian Jin Fang
1025 A.D. · The Canon of Medicine
1078 A.D. · Tai Ping Hui Min He Ji Ju Fang
Twelfth century · rGyud bzhi (The Four Tantras)
1740 A.D. · Wai Ke Zheng Zhi Quan Sheng Ji

Current Issue     05 November 2019, Volume 4 Issue 6 Previous Issue   
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News
Tu Youyou:A scientist moving forward in controversy
Editor Group of Traditional Medicine Research
1Traditional Medicine Research. 2019, 4 (6): 288-289.   https://doi.org/10.12032/TMR20190922136
Abstract ( 129 )   HTML ( 0 )     PDF (305KB) ( 31 )  

The 13th National People's Congress Standing Committee was held in Beijing on Sept. 17, 2019. President of China Xi Jinping signed a presidential decree to award individuals, national medals and honorary titles. Tu Youyou, the winner of the 2015 Nobel Prize in physiology or medicine, was awarded the Medal of the Republic [1].

As the winner of the 2015 Nobel Prize in physiology or medicine, Tu Youyou and her team, discovered that artemisinin and dihydroartemisinin could be used to treat malaria [2]. Although Tu Youyou won the Nobel Prize in 2015, she didn’t have a Ph.D. degree. In 2017, she did not been admitted to the Chinese Academy of Sciences again [3].

As early as Oct. 9, 2015, <em>The New York Times</em> reported, “Q. and A.: Tu Youyou on Being Awarded the Nobel Prize”: “Q: Are you disappointed not to have been admitted to the Chinese Academy of Sciences? A: I applied many times, because people told me I should. I did receive a few awards for the discovery. At the National Science Conference in 1978, my team was given an award. As the team leader, I accepted on behalf of the team. The Minister of Public Health personally recommended me for academy membership. However, many factors must come into play. It’s complicated [4].”

Usually, the Nobel Prize is awarded to individuals only [5]. Research of artemisinins has been carried out since the early 1970s, by hundreds of scientists all together under the “whole nation" system. For example, Xu Liu of Guilin Pharmaceutical Company designed and synthesized dihydroartemisinin C10-monoesters of diacids [6]. “Tu was the first to show that this component, later called Artemisinin, was highly effective against the malaria parasite, both in infected animals and humans.”the Nobel Committee said [7].

In 2011, Tu Youyou was awarded by the Lasker Foundation. The Lasker Award is often seen as a precursor to the Nobel Prize. This event reignited a controversy over whether one person should be recognized for developing the drug. Some Chinese scientists even co-authored letters to the Nobel Committee, stating that "We would rather no-one have this Nobel Prize, rather than Tu Youyou have it alone [8, 9]." 

It is noted that Tu Youyou turned to ancient texts of Chinese medicine named <em>Zhouhou Beiji Fang</em> and discovered clues to identify and extract the active component of the Chinese herbal medicine Qinghao (<em>Artemisia carvifolia</em>&nbsp;Buch.-Ham. ex Roxb. Hort. Beng.). She then delivered her Nobel Lecture titled “Discovery of Artemisinin - A Gift from Traditional Chinese Medicine to the World” on Dec. 17, 2015 at Aula Medica, Karolinska Institutet in Stockholm [10]. This made traditional medical practitioners, especially Chinese medicine practitioners very excited as they hoped it would bring some positive publicity to usefulness of traditional medicine. However, the Prize motivation on official website is still just "for her discoveries concerning a novel therapy against Malaria [2]."

On May 30, 2019, the latest research results of the Tu Youyou team were published on <em>The New England Journal of Medicine</em> titled A Temporizing Solution to “Artemisinin Resistance" [11]. In addition, the application for the "Clinical trial of dihydroartemisinin tablet in the treatment of systemic lupus erythematosus and discoid systemic lupus erythematosus" submitted by the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, where the Tu Youyou team is located, has been approved. Kunming Pharmaceuticals, Inc. is the responsible party [12].

Comment
The research of acupuncture on the treatment of alcohol dependence: hope and challenge
Xue Yang
1Traditional Medicine Research. 2019, 4 (6): 290-292.   https://doi.org/10.12032/TMR20191009138
Abstract ( 95 )   HTML ( 3 )     PDF (295KB) ( 74 )  
Acupuncture, a well-known form of alternative therapy, has been used for treating various disorders including pain, certain drug addiction, and withdrawal syndromes [1-5]. Although there is not any histological or physiological evidence of traditional Chinese medical concepts such as Qi, meridians and acupoints, there is clear scientific evidence that acupuncture relates to endogenous opioid peptides release, and acupuncture can increase the activity of dopaminergic neuron in mesolimbic brain region through the endogenous opioid peptides [6-8]. Till today, there is no convincing evidence to illustrate the nature of acupoints and also no clear mechanism explaining how the signals transport to the central nervous system from the special acupoints. However, recent research have found that the afferent impulses induced by acupuncture can be transmitted by Aβ and AΔ fibers [9, 10], which sent the itch and tactile sensation to the brain; then the signals activate spinal cord, midbrain and pituitary-hypothalamus, which lead to the release of three endorphins and other monoamines [11-13]. These results suggest that acupuncture can indeed activate neurons in the brain to perform physiological functions.
Special Issue on Endocrine and Metabolism
A systematical review of traditional Ayurvedic and morden medical perspectives on Ghrita (clarified butter): a boon or bane
Vd. Varnika Singh, Vd. Shalini Rai, Vd. Vijay Kumar Rai
1Traditional Medicine Research. 2019, 4 (6): 293-304.   https://doi.org/10.12032/TMR20190325111
Abstract ( 323 )   HTML ( 4 )     PDF (435KB) ( 101 )  

Highlights

Ghrita (clarified butter), treated as the culprit of a number of diseases, has been depicted incorrectly for a long time. This review presents the complete picture in view of Ayurvedic perspective and recent researches on Ghrita to let the readers contemplate again on Ghrita.

Traditionality

Ghrita, also called as clarified butter in Sanskrita, has been used for more than 5, 000 years throughout the Indian subcontinent and has been an inevitable part of diet in the Indian cuisine. It has also been traditionally associated with a number of health benefits recorded in Charaka (the most ancient written text of Ayurveda dating to second century B.C.), such as promoting strength and longevity, promoting appetite and digestion, increasing cognition, etc.

Abstract

Background: For long dietary guidelines, it is recommended to avoid foods rich in saturated fatlike Ghrita, also named clarified butter or ghee, which is considered as the culprit of cardiovascular diseases, diabetes, stroke, etc. Contradictory to the modern medical science, Ayurveda advocated for numerous benefits of the usage of Ghrita in the judicious manner. This paper systematically reviews and analyses the scientific researches that carried out on the benefits and harms associated with the usage of Ghrita. Methods and Findings: A search over the various search engines like Pubmed, Google was made. The relevant articles and chapters from books retrieved in English language were saved to a folder and analysed for their utility relevant to the topic and the matter was presented in a systematic manner. Results: Ghrita consisted various fats (saturated, monosaturated and polyunsaturated), fatty acids, minerals, vitamins etc. And the composition of Ghrita varies along with the method of preparation. Scientific researches carried out on Ghrita plain as well as medicated have reported about the depressant effects of medicated Ghrita in gross behavioural tests, potentiated phentobarbitone sleeping time, analgesic effect and stimulatory effect on cognition. Further, studies conducted to evaluate the effect of Ghrita on the serum lipid levels showed a dose dependant decrease in the total cholesterol, low density lipoproteins, and very low density lipoproteins. Ghrita was also reported to have wound healing activity. Conclusion: The results of the study suggest the beneficial effects of plain as well as medicated Ghrita on the various components of health and break the myth associated to the exclusion of Ghrita in diet. These researches also substantiate the claims made by the classical texts of Ayurveda.


Traditionality
Ghrita, also called as clarified butter in Sanskrita, has been used for more than 5, 000 years throughout the Indian subcontinent and has been an inevitable part of diet in the Indian cuisine. It has also been traditionally associated with a number of health benefits recorded in Charaka (the most ancient written text of Ayurveda dating to second century B.C.), such as promoting strength and longevity, promoting appetite and digestion, increasing cognition, etc.
Effects of Siwei Yuganzi decoction on LXRα and CYP7A1 in hyperlipidemic rats
Ru-Yi Yang, Hong-Bin Wang, Pan-Pan Zhou
1Traditional Medicine Research. 2019, 4 (6): 305-313.   https://doi.org/10.12032/TMR20191024142
Abstract ( 194 )   HTML ( 1 )     PDF (1045KB) ( 35 )  

Highlights

A Tibetan (one of the ethnic minorities in China) compound preparation, Siwei Yuganzi decoction, can improve the serum levels of TC, TG, and LDL-C in the hyperlipidemic animal model via increasing the expression of both LXRα and CYP7A1 mRNA and proteins in the liver tissue.

Traditionality

Siwei Yuganzi decoction is an adaptation of a classical prescription of the Tibetan medicine called Sanguo decoction, which is recorded in the classic ancient book of Tibetan medicine entitled Sibu Jingdian, written by the famous Tibetan medical scientist named G.yuthog Rnyingma·Yontan Mgonpo in 800 C.E..

Abstract

Background: Hyperlipidemia (HLP) is a disorder in which lipids in the blood are disturbed due to abnormal lipid metabolism. Statins and fibrates lipid-regulating drugs prevent the generation of lipids and improves HLP, thereby reducing the likelihood of developing cardiovascular and cerebrovascular diseases. However, their adverse reactions and side effects limit a wide range of clinical applications. Tibetan medicine compound preparation Siwei Yuganzi decoction (SYD) is an adaptation of a classical prescription of the Tibetan medicine Sanguo decoction, that has been proved to have the effect of improving lipid metabolism; however, its possible mechanism remains unknown. Methods: Sixty specific-pathogen free grade Sprague Dawley rats were randomly divided into the blank control group, the HLP group, the Chinese patent medicine Xuezhikang positive control group, and the treatment groups with Tibetan SYD high-, middle-, and low-dosages respectively. Ten rats were assigned to each group. Every rat in these groups was fed with a high-fat emulsion to establish the hyperlipidemic animal model, except for those in the blank control group. Then the rats in the blank control and HLP groups were fed with 0.9% normal saline, those in Xuezhikang group were fed with Xuezhikang suspension at the dose of 0.11 g/kg/d, and those in SYD groups were fed with the SYD suspension at the dosage of 16.2 g/kg/d (high dosage), 10.8 g/kg/d (middle dosage), and 5.4 g/kg/d (low dosage), respectively. After 8 weeks, the levels of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were detected by the ELISA. The mRNA and protein expression levels of liver X receptor α (LXRα) and cholesterol 7α-hydroxylase 1 (CYP7A1) were detected using RT-PCR, western blotting, and immunohistochemistry. Results: The serum levels of TC, TG, and LDL-C in the HLP group were higher than those in the blank control group (P < 0.05), whereas the serum levels of HDL-C and the expression levels of both LXRα and CYP7A1 mRNA and proteins in the liver in the HLP group were lower than those in the control group (P < 0.05). After the treatment of the Xuezhikang and SYD, the serum levels of TG, TC, and LDL-C significantly decreased (P < 0.05), whereas the serum levels of HDL-C and the expression levels of both LXRα and CYP7A1 mRNA and proteins in the liver significantly increased compared with those in the HLP group (P < 0.05). Furthermore, The serum levels of TC, TG, and LDL-C in the SYD group at high dosage were lower (P < 0.05), the serum level of HDL-C was higher, and the expression levels of both LXRα and CYP7A1 mRNA and proteins in the liver tissue were higher than those in the Xuezhikang group (P < 0.05). Conclusion: SYD can improve the serum levels of TC, TG, and LDL-C in the hyperlipidemic animal model via increasing the expression of both LXRα and CYP7A1 mRNA and proteins in the liver tissue.


Traditionality 

Siwei Yuganzi decoction is an adaptation of a classical prescription of the Tibetan medicine called Sanguo decoction, which is recorded in the classic ancient book of Tibetan medicine entitled Sibu Jingdian, written by the famous Tibetan medical scientist named G.yuthog Rnyingma·Yontan Mgonpo in 800 C.E..

Effectiveness of health coaching on diabetic patients: A systematic review and meta-analysis
Nashwa Mohamed Radwan, Hisham Al Khashan, Fahad Alamri, Ahmed Tofek El Olemy
1Traditional Medicine Research. 2019, 4 (6): 314-325.   https://doi.org/10.12032/TMR20191024143
Abstract ( 77 )   HTML ( 1 )     PDF (802KB) ( 45 )  

Highlights

Health coaching intervention has a significant effect on hemoglobin A1c and high-density lipoprotein cholesterol of patients with diabetes mellitus.

Traditionality

The first use of the term "coach" arose around 1830 in Oxford University as a slang in relation with an instructor or trainer or tutor who "carried" a student through an exam. The term “coaching” thus refers to the process of transporting people from where they are to where they want to be. In 1915, the National Board of Medical Examiners was founded. In 2002, Wellcoaches partnered with the American College of Sports Medicine. In 2010, the National Consortium for Credentialing Health and Wellness Coaches was founded. In 2017, the International Consortium for Health and Wellness Coaching was established. Coaching as a method to improve healthy lifestyle behaviors has received special attention in recent years.

Abstract

Background: Using health coaching to improve the quality of life and health outcomes of the patients with diabetes mellitus, has emerged as a possible intervention. However, the few published randomized controlled trials using health coaching for patients with diabetes mellitus have reported mixed results. The present meta-analysis aimed to determine the effectiveness of health coaching on modifying health status and quality of life among diabetic patients and to clarify the characteristics of coaching delivery that make it most effective. Methods: This study searched for articles on randomized controlled trials of health coaching interventions targeting type 2 diabetic patients that were published in the English language from January 2005 through December 2018 in the Cochrane, Medline, PubMed, Trip, and Embase databases. Patients in the control group received usual diabetes mellitus care, and those in the experimental group received health coaching based on usual diabetes mellitus care. The primary outcomes included Hemoglobin A1c (HbA1c) and cardiovascular disease risk factors, including systolic blood pressure, diastolic blood pressure, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, total cholesterol, and body weight. The secondary outcomes included quality of life, self-efficacy, self-care skills, and psychological outcomes. Results: Health coaching intervention has a significant effect on HbA1c [mean difference (MD) = -0.35, confidence interval (CI) = -0.47, -0.22, I2 = 83%, P < 0.001] and HDL-C (MD = -0.50, CI = -0.93, -0.07, I2 = 10%, P = 0.02). The most effective strategy for health coaching delivery associated with improvement of HbA1c was decreasing the number of sessions and increasing the duration of each session. However, no significant difference was found for weight, SBP, diastolic blood pressure, triglyceride, low-density lipoprotein cholesterol, or total cholesterol. Mixed results were reported for the effect of health coaching on quality of life, self-efficacy, self-care skills, and depressive symptoms outcome. Conclusion: Health coaching intervention has a significant effect on HbA1c and HDL-C, and the most effective strategy is decreasing the number of sessions while increasing session duration. However, these results should be interpreted with caution as the evidence comes from studies at some risk of bias with considerable heterogeneity and imprecision.


Traditionality 

The first use of the term "coach" arose around 1830 in Oxford University as a slang in relation with an instructor or trainer or tutor who "carried" a student through an exam. The term “coaching” thus refers to the process of transporting people from where they are to where they want to be. In 1915, the National Board of Medical Examiners was founded. In 2002, Wellcoaches partnered with the American College of Sports Medicine. In 2010, the National Consortium for Credentialing Health and Wellness Coaches was founded. In 2017, the International Consortium for Health and Wellness Coaching was established. Coaching as a method to improve healthy lifestyle behaviors has received special attention in recent years.

Study on the relationship between the structure of bacterial flora on the tongue and types of tongue coating in patients with type 2 diabetes mellitus
Yu-Hong Ding, Xing-Yu Zheng, Wei-Wei Chen, Xin-Fu Lin, Xiao Yang, Jie-Wei Luo, Fang-Meng Huang, Yong-Xi Wu, Shi-Chao Wei
1Traditional Medicine Research. 2019, 4 (6): 326-337.   https://doi.org/10.12032/TMR20190530122
Abstract ( 240 )   HTML ( 3 )     PDF (1423KB) ( 100 )  

Highlights

The incidence of type 2 diabetes mellitus (T2DM) is related to the imbalance of oral microflora in the human body. The characteristic tongue coating flora structure, containing Prevotella, Fusobacterium, Streptococcus, Neisseria, etc., can influence the formation of yellow thick coating. However, the role of yellow thick coating in the incidence of T2DM needs further investigation.

Traditionality

Diabetes is called “Xiaoke” in traditional Chinese medicine. According to the record of Jin Kui Yao Lue (an ancient book of Chinese medicine published in the Han dynasty of China), the typical clinical symptoms of “Xiaoke” is thirsty for drinking water and dry mouth, suggesting that as early as Han dynasty, Chinese medicine associated the onset of diabetes with the mouth and tongue symptoms. Currently, it is believed that a two-way interaction exists between diabetes and periodontitis, a disease resulted from the imbalance oral microbial community. In 2015, “National Individual Microbiome Detection Project” was launched with the aim of finding biomarkers or risk factors for diseases in oral, skin, and intestinal microbial communities.

Abstract

Objective: To analyze the characteristics of bacterial flora on the tongue and types of tongue coating between healthy individuals and patients with type 2 diabetes mellitus (T2DM) via detecting 16S rDNA of oral tongue coating microbial group. Methods: A total of 42 patients with T2DM were recruited, including 6 with thin white coating, 9 with mirror-like coating, 27 with yellow thick coating (YTC), and 28 healthy individuals. The V4 region of 16S rDNA from the tongue coating microbiota was sequenced using the Linux ubuntu sequencing platform, and the structure of bacterial flora in the tongue was analyzed. Treeplot construction, principal coordinates analysis, redundancy analysis, and linear discriminant analysis were conducted using R software to analyze the differences of bacterial flora in the tongue coating in each group. Results: A total of 8131 different operational taxonomic units (OTUs) were obtained via sequencing, of which 719 OTU samples showed significant differences (P < 0.05). Comparing OTUs with the 16S rDNA database of known species and annotation of parallel species revealed 16 species with differences at the phylum level, 31 at the class level, 54 at the order level, 88 at the family level, and 161 at the genus level. The dominant bacteria found in patients with T2DM included Lactobacillus, Streptophyta, Chloroplast, Cyanobacteria-Chloroplast, and Bifidobacteriaceae, etc. Dominant bacteria in the control group belonged to Pasteurellales, Pasteurellaceae, Leptotrichiaceae, Lachnoanaerobaculum, and Ignavibacteria among other bacterial families. All samples were clustered into three groups, each group characterized by dominant bacteria. The order of dominant bacteria in group 1 were Prevotella > Neisseria > Veillonella > Streptococcus > Fusobacterium > Leptotrichia and so on. The order of dominant bacteria of group 2 were Neisseria > Prevotella > Fusobacterium > Streptococcus > porphyromonas and so on. The dominant bacteria of group 3 were Prevotella > Fusobacterium > Streptococcus > Neisseria > Leptotrichia > Rothia > Veillonella > porphyromonas > f_Pasteurellaceae > Capnocytophaga > Actinomyces > Alloprevotella and so on. Single factor risk estimation: with group 1 used as the reference (OR = 1), the risk of carrying group 2 and group 3 microflora with T2DM increased (OR values were 4.77 and 7.78, respectively). The proportion of group 1 microflora in the control group (25.9%) was higher than that in the T2DM group (5.4%) (χ2 = 3.873, P = 0.049). Compared with group 1 and group 2, group 3 had a significantly dominant microflora structure in YTC group (χ2 = 7.120, P = 0.008). RDA analysis indicated that Neisseria, Fusobacterium, and Prevotella were associated with HbA1c values > 10 mmol/L, whereas Rothia, Streptococcus, and Veillonella were more correlated with HbA1c ≤ 10 mmol/L. Conclusion: The incidence of T2DM is related to the imbalance of oral microflora in the human body. The tongue coating flora structure may influence the formation of different tongue coating types in this metabolic condition. Additionally, flora structures of Prevotella, Neisseria, and Fusobacterium were associated with elevated HbA1c.


Traditionality

Diabetes is called “Xiaoke” in traditional Chinese medicine. According to the record of Jin Kui Yao Lue (an ancient book of Chinese medicine published in the Han dynasty of China), the typical clinical symptoms of “Xiaoke” is thirsty for drinking water and dry mouth, suggesting that as early as Han dynasty, Chinese medicine associated the onset of diabetes with the mouth and tongue symptoms. Currently, it is believed that a two-way interaction exists between diabetes and periodontitis, a disease resulted from the imbalance oral microbial community. In 2015, “National Individual Microbiome Detection Project” was launched with the aim of finding biomarkers or risk factors for diseases in oral, skin, and intestinal microbial communities.

Treatment of diabetic foot ulcer with medicinal leech therapy and honey curcumin dressing: a case report
Shirbeigi Laila, Eghbalian Fatemeh, Bakhtyari Lida
1Traditional Medicine Research. 2019, 4 (6): 338-344.   https://doi.org/10.12032/TMR20190728128
Abstract ( 417 )   HTML ( 7 )     PDF (393KB) ( 179 )  

Highlights

Wound healing impairment and ulcers in the foot, with pain and disability, are common complications of diabetes. The present case report shows the effectiveness of leech therapy in combination with honey and curcumin dressing on disease progression in a patient with diabetic foot ulcer.

Traditionality

In Iranian traditional medicine, leeches are used to treat many diseases. Natural honey and curcumin are available for dressing all types of ulcers. Hakim Aghili reported several operative properties that make them appropriate for wounds. Medicinal leech therapy was first documented in a painting of an Egyptian tomb in 1500 B.C.E. Subsequently, the use of leech therapy for medicinal purposes increased dramatically in the 17th and 18th centuries in Europe and Asia. In 1960s, leeches were used in reconstructive surgery to eliminate intravenous congestion. In 1970s, leech therapy was used only in microsurgeries. The Food and Drug Administration legalized medicinal leech therapy in 2004.

Abstract

Background: Diabetic foot ulcers (DFUs) are common in patients with diabetes. The mortality rate of DFUs is ranked the highest after cancer. With advancements in modern medicine, leech therapy, a traditional treatment method for chronic wounds in Iranian medicine, has proven effective in relieving venous congestion. Herein, we aimed to observe the curative effects of leech therapy in combination with honey and curcumin dressing in a 77-year-old patient with a diabetic foot ulcer (UFC). Methods: Two medium-sized medicinal leeches were placed surrounding a grade 2 wound, based on Wagner’s classification system, located on the right first toe. The patient reported a visual analogue scale (VAS) score of 8. After leech therapy, the wound was covered with honey and curcumin, followed by oral administration of ciprofloxacin for 10 days. Results: Pain increased immediately after leech therapy (VAS: 9-10) but decreased significantly (VAS: 6) 2 days after the therapy. At the end of the 2nd day, pain completely disappeared. After 3 weeks, there was no wound on the toe. After 12 weeks, there were no traces of the wound. Conclusion: Leech therapy in combination with honey and curcumin dressing is effective against disease progression in patients with DFUs.


Traditionality 

Diabetes is called “Xiaoke” in traditional Chinese medicine. According to the record of Jin Kui Yao Lue (an ancient book of Chinese medicine published in the Han dynasty of China), the typical clinical symptoms of “Xiaoke” is thirsty for drinking water and dry mouth, suggesting that as early as Han dynasty, Chinese medicine associated the onset of diabetes with the mouth and tongue symptoms. Currently, it is believed that a two-way interaction exists between diabetes and periodontitis, a disease resulted from the imbalance oral microbial community. In 2015, “National Individual Microbiome Detection Project” was launched with the aim of finding biomarkers or risk factors for diseases in oral, skin, and intestinal microbial communities.

Errata Notice
Errata Notice
Editor Group of Traditional Medicine Research
1Traditional Medicine Research. 2019, 4 (6): 345-345.   https://doi.org/10.12032/TMR20191022140
Abstract ( 63 )     PDF (316KB) ( 24 )  

On page 177, “确认是和 DNM 还是 DN 比较?” was a text comment written by an editor for fact checking purposes. It should have been removed before publishing. 

We deeply apologize to the readers and the authors of this article for this publishing mistake.

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  • Efficacy and safety of traditional Chinese medicine kidney-nourishing formula for Alzheimer's disease in comparison with donepezil: a systematic review and meta-analysis 
    ...
    Highlights 
    Compared with donepezil, the long-term treatment of kidney-nourishing (The the change of pathological state of kidney deficiency by means of traditional Chinese medicine (TCM) treatment and so on) formula in TCM can significantly improve the Alzheimer's disease assessment scale-cognitive subscale score and the activities of daily living score. 
    Traditionality 
    The description of dementia-related symptoms can be found in historical book entitled Zuo Zhuan (The Spring and Autumn Annals) (722 B.C.E.-–468 B.C.E.) in the Pre-Qin Dynasty, and the name of Chidai was first proposed by Sun Simiao in Huatuo Shenyi Mizhuan (Biography of Hua Tuo's Medicine) (618 B.C.E.-–907 C.E.), a Chinese medicine classical book published in the Tang Dynasty. The Chinese medicine classical book entitled Huangdi Neijing (The Yellow Emperor's Internal Classic) (221 B.C.E.-–220 C.E.) provides a theoretical basis for establishing a link between kidney and dementia. Therefore, nourishing kidney (the changes of pathological state of kidney deficiency by means of TCM treatment and so on) has become an important treatment for dementia by TCM clinicians nowadays. 
    Abstract 
    Objective: Finding an effective therapy against Alzheimer’s disease (AD) has been associate increasingly pressing issue and traditional Chinese medicine (TCM) is widespread in the prevention and treatment of AD in China. The aim of this study was to judge the efficaciousness and safety of TCM kidney-nourishing (the changes of pathological state of kidney deficiency by means of TCM treatment and so on) formula (TKNF) for AD in comparison with donepezil. Methods: The retrieval period of seven databases was from the establishment of each database to April 2019. Two authors independently identified randomized controlled trials (RCTs), fetched data and assessed bias risk. Comprehensive analysis process was conducted with review manager for eligible and appropriate RCTs. Results: A complete of 981 AD patients from 13 studies were enclosed. Meta-analysis of RCTs showed that there was no significant difference in the improvement of Alzheimer's disease assessment scale-cognitive subscale score between 2 groups in short term, but the effect of long-term treatment may exceed donepezil; there was a significant difference in the improvement of activities of daily living score between 2 groups; there was a significant difference in TCM curative efficacy between 2 groups with long-term treatment. There was no significant difference in the incidence of adverse events between 2 groups. The quality of the evidence was high or moderate. Conclusion: Compared with donepezil, TKNF was an effective drug for AD patients and the clinical application of TKNF was safe. TKNF's long-term benefits need more evidence to verify.
    ...
    Fei-Zhou Li, Yi-Ni Zhang, Tong Zhang, Ling Liu, Ping Wang
  • Dissecting the underlying pharmaceutical mechanism of Danggui Buxue decoction acting on idiopathic pulmonary fibrosis with network pharmacology 
    ...
    Highlights
    Kaempferol and quercetin are found to be the two main compounds of classical prescription of traditional Chinese medicine named Danggui Buxue decoction with the highest network regulation, which can inhibit the transformation of fibroblasts into myofibroblasts and reduce the expression of fibrosis markers α-smooth muscle actin, collagen 1, fibronectin.

    Traditionality
    Danggui Buxue decoction (DBD), a classical prescription in traditional Chinese medicine composed of Huangqi (Radix Astragali) and Danggui (Radix Angelicae Sinensis) in a ratio of 5:1, originates from the Chinese medicine ancient book entitled Neiwai Shangbian Huolun written by the famous medical scientist Li Dongyuan in 1247 C.E. At present, there are many researchers who try to study the biological activity of individual chemical components in DBD and the mechanism of action of whole formula. Some studies have shown that DBD has effect on fibrosis of heart, liver and kidney and has protective effect on bleomycin-induced pulmonary fibrosis in rats by reducing alveolar inflammation and fibrosis.

    Abstract

    Backgroud: Danggui Buxue decoction (DBD), a classical prescription in traditional Chinese medicine, has been found to have protective effect on bleomycin-induced pulmonary fibrosis in rats by reducing alveolar inflammation and fibrosis. However, the biological activity of individual chemical components and mechanism of action of whole formula are not clear. Methods: Potential targets of active ingredients of DBD were collected through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and SymMap database. Target genes related to idiopathic pulmonary fibrosis were obtained from the Online Mendelian Inheritance in Man database, Therapeutic Targets Database and Gkb database. Then, the common targets were obtained by overlapping the potential targets of active ingredients in DBD and diseases related targets. The selected targets were subjected to Kyoto Encyclopedia of Genes and Genomes signaling pathway and Gene Ontology analysis, and the network map of active component-target-pathway was established using Cytoscape 3.7.1 software. The active components of DBD with most targets were selected for fibrosis-related marker verification. The mRNA and protein expression of fibrosis markers, α-smooth muscle actin, collagen 1 and fibronectin, were detected in TGF-β1-induced fibroblast cell line after treatment with the active components. Results: The 14 active ingredients, such as quercetin and kaempferol, were screened from DBD. It acts on 26 targets like estrogen receptor 2 and prostaglandin-endoperoxide synthase 2, and mainly involves 38 signaling pathways such as cell inflammation and autophagy. Kaempferol and quercetin are the two compounds with the highest network regulation, which can inhibit the transformation of fibroblasts into myofibroblasts and reduce the expression of fibrosis markers α-smooth muscle actin, collagen 1 and fibronectin. Conclusion: The integration mode of multi-component, multi-target, multi-channel and mechanism of DBD in the treatment of idiopathic pulmonary fibrosis are predicted by means of network pharmacology. Our study could indicate the direction of further anti-fibrotic mechanism research.
    ...
    Cai-Ping Zhao, Hang Li, Xiao-Hong Liu, Shuang Liang, Xue-Lei Liu, Xin-Rong Li, Yi Luo, Mei-Ling Zhu
  • Frequent attacks on health workers in China: social changes or historical origins? 
    ...

    According to a message posted by the official Weibo account of Chengguan Sub-bureau of the Lanzhou Public Security Bureau in Gansu Province of China, on the morning of October 22, 2019, a suspect named Yang (male, aged 54 years, a native of Lanzhou City of Gansu Province) attacked a doctor Feng (female, aged 42 years, a native of Lanzhou City) with a knife at Gansu Provincial Hospital. Unfortunately, despite all efforts to rescue her, Feng passed away. After the incident, Public Security Institutions immediately took control of suspect Yang. According to the preliminary investigation, Yang once underwent a surgery for rectal cancer at Gansu Provincial Hospital, in which Doctor Feng was his attending physician. The case is currently under further investigation [1]. 

    History book entitled Shi Ji (the Grand Historian) combines the biographies of famous doctors Bian Que and Chunyu Yi into the Bian Que Cang Gong Lie Zhuan (Biography of Bian Que and Cang Gong) [2]. According to the record of Shi Ji, as early as in the Zhou Dynasty (1046-256 B.C.E.) of China, Bian Que (407-310 B.C.E.) died from murder. When the chief physician of Qin State Li Xi—learned that his medical skills were not as good as Bian Que’s, he sent an assassin to kill him.

    ...
    Editor Group of Traditional Medicine Research
  • The marriage of Chinese Imperial Medicine and China Academy of Chinese Medical Sciences: privilege and benefits for the people 
    ...

    On September 27, 2019, the Palace Museum and China Academy of Chinese Medical Sciences held a signing ceremony of strategic cooperation at Jingsheng Zhai (The studio of esteemed excellence) in the garden of Jianfu Gong (The palace of established happiness) at the Palace Museum.

    This cooperation will focus on the vast collection of cultural relics on traditional Chinese medicine (TCM) in the Palace Museum and represents a joint venture into the scientific study of TCM cultural relics from the court of the Qing dynasty of China (1636 C.E.-1912 C.E.) [1].

    Tai Yi Ling (Chief imperial physician) was recorded in the Records of Shiji (the Grand Historian) (Figure 1a) [2, 3]. The famous doctor Bian Que died in 310 B.C.E, who’s exact death details are unclear until now. But there is a thought that he was assassinated by Li Xi, who was a chief imperial physician in the state of Qin, and the reason of the murder was jealousy [3] .

    The name of the Tai Yi Yuan (Imperial medical academy) originated from the Jin dynasty of China (1115 C.E.-1234 C.E.), and was inherited from the Tai Yi Shu (Imperial medical office) and Tai Yi Ju (Imperial medical bureau) of the Tang (618 C.E.-907 C.E.) and Song dynasties of China (960 C.E.-1279 C.E.). Between 1078 C.E. and 1085 C.E. of the Song dynasty, the imperial medical bureau collated and published its formula blueprints under the title Taiyiju Fang (Formulary of the imperial medical bureau). After several rounds of revision and supplementation, the text was eventually finalized after final additions were made between 1225 C.E. and 1227 C.E. as well as 1241 C.E. and 1252 C.E., becoming the current popularized version known as Taiping Huimin Hejiju Fang (Formulary to benefit the people from the pharmaceutical bureau of the Taiping reign) (Figure 1b) [4]. The medical classics named Yuyaoyuan Fang (Formulary of the imperial pharmacy) of the Yuan dynasty (1279 C.E.-1368 C.E.) was revised and edited by Xu Guozhen and others using Yuyaoyuan Fang (Formulary of the imperial pharmacy) (Figure 1c) of the Jin dynasty as base text. It was finalized in 1267 C.E. and is an important material for studying the medical formulae of the courts of the Jin and Yuan dynasties (1271 C.E.-1368 C.E.) [5].

    Imperial medical academies were established in all subsequent dynasties [2]. The Imperial medical academy of the Ming dynasty of China (1368 C.E.-1644 C.E.) was a central institution that managed the diagnosis and pharmacy services of the court and nobility [6]. Li Shizhen, a famous medical scientist in ancient China, was appointed an official at the imperial medical academy in Beijing at 27 years old. In 1549 C.E., the 28th year of Jiajing emperor of the Ming dyansty, Li Shizhen resigned from his position at the imperial medical academy at the age of 32 and returned to Ganzhou city of China. He wrote the medical classics named Bencao Gangmu (Compendium of materia medica) in his later years (Figure 1d) [7].
    ...
    Editor Group of Traditional Medicine Research

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