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1Traditional Medicine Research  2019, Vol. 4 Issue (4): 178-183    DOI: 10.12032/TMR20190306109
Special Issue on Integrative Surgery     
Acupuncture preconditioning protects against myocardial ischemia/reperfusion injury mediated apoptosis through miR-214/NCX1 activation: a hypothesis
Hai-Long Fan1,*(), Yu-Lan Ren2, Li-Zhen Yang1, Fei Wu2
1Hohhot Hospital of Mongolian Medicine and Traditional Chinese Medicine, Hohhot, China.
2School of Acupuncture Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
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Highlights

This review provides evidences for the recommendation of acupuncture preconditioning at Neiguan (PC6) point in coronary heart disease patients as a non-pharmacological therapeutic method to activate the miR-214/NCX1 pathway.

Traditionality

The concept of acupuncture preconditioning is described in the ancient book of Fan Wang Fang (Eastern Jin Dynasty of China). It refers to the application of acupuncture before the occurrence of disease or when the disease is relatively mild. According to the record of the ancient book of Huang Di Nei Jing (Qin Han Period of China, 475 B.C.-221 B.C.), acupuncture at Neiguan (PC6) point can prevent and treat angina pectoris in coronary heart disease (CHD). The WHO also recommends acupuncture as one of the alternative and complementary therapies for the prevention and treatment of angina pectoris in CHD.

Abstract

Early reperfusion of ischemic cardiac tissue is usually the best option to improve clinical outcome of angina pectoris, especially of acute myocardial infarction. However, myocardial reperfusion may cause an abnormal increase of intracellular Ca2+-mediated cardiomyocyte death and consequent loss of cardiac function, which is referred to myocardial ischemia/reperfusion (I/R) injury. Recently, the microRNA-214 (miR-214)/Na+/Ca2+ exchanger (NCX) 1 co-expression is a key factor in cellular protection against myocardial apoptosis for myocardial I/R injury. Once activated, miR-214/NCX1 axis can inhibit several Ca2+ downstream signaling effectors that mediate cell death simultaneously. Studies have shown that acupuncture preconditioning has a protective effect on myocardial I/R injury, but its mechanism deserves further research. It has been proved that acupuncture preconditioning for ischemic myocardium successfully inhibit multiple Ca2+ handling related microRNAs that mediate cell death pathways, and miR-214 is one of its targets. In terms of clinical practice, coronary heart disease (CHD) patients benefit a lot from this intervention. However, there is barely no study correlating acupuncture preconditioning to the miR-214/NCX1 co-expression in patients with CHD. This review aims to discuss whether there is some evidence to justify a recommendation of acupuncture preconditioning in CHD patients as a non-pharmacological therapeutic method to activate the miR-214/NCX1 co-expression network model.



Key wordsMiR-214/NCX1      Acupuncture preconditioning      Coronary heart disease      Myocardial ischemia      Reperfusion injury     
Published: 05 July 2019
Fund:  This study is supported fiancially by the Natural Science Foundation of Inner Mongolia Autonomous Region in China (Grant No.2018MS08043), the National Natural Science Foundation of China (Grant No.81573885), Project of Huhhot Science and Technology (Grant No.2018-Sociology-1-3) and Research Project of Health and Family Planning Commission of Inner Mongolia in China (Grant No.201703145). The funders will not have any impact on the trial and the publication of the results.
Corresponding Authors: Hai-Long Fan   
E-mail: zjfhl1977@163.com
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Cite this article:

Hai-Long Fan, Yu-Lan Ren, Li-Zhen Yang, Fei Wu. Acupuncture preconditioning protects against myocardial ischemia/reperfusion injury mediated apoptosis through miR-214/NCX1 activation: a hypothesis. 1Traditional Medicine Research, 2019, 4(4): 178-183. doi: 10.12032/TMR20190306109

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https://www.tmrjournals.com/tmr/EN/10.12032/TMR20190306109

Figure 1 A miRNA-214/NCX1 mRNA co-expression network model for blocking myocardial apoptosis
I/R, Ischemia/reperfusion; NCX1, Na+/Ca2+ exchanger 1; BCL2, B-cell leukemia/lymphoma 2; CaMKIIδ, Calmodulin-dependent protein kinase II δ.
Figure 2 Figue 2 A miRNA-214/NCX1 mRNA co-expression network model for blocking myocardial apoptosis: a novel hypothesis for acupuncture’s protective mechanism against myocardial I/R injury
I/R, Ischemia/reperfusion; NCX1, Na+/Ca2+ exchanger 1; BCL2, B-cell leukemia/lymphoma 2; CaMKIIδ, Calmodulin-dependent protein kinase II δ.
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