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1Traditional Medicine Research  2019, Vol. 4 Issue (4): 174-177    DOI: 10.12032/TMR20190415116
Is IL1R1 required for celastrol’s leptin-sensitization and antiobesity effects?
Yuan Yao1, Long Ma1,*()
1State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology (Ministry of Education), Tianjin Key Laboratory of Industry Microbiology, School of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
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The article by Xudong Feng et al. [1], published on 4 March 2019 in the journal of Nature Medicine, showed the relationship between natural product celastrol and obesity. The researchers demonstrated celastrol was able to sensitize leptin and displayed antiobesity effects through IL1R1 (Interleukin-1 receptor 1). It was proved that IL1R1 was a gatekeeper for celastrol’s metabolic actions.

Published: 05 July 2019
Corresponding Authors: Long Ma   
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Yuan Yao, Long Ma. Is IL1R1 required for celastrol’s leptin-sensitization and antiobesity effects?. 1Traditional Medicine Research, 2019, 4(4): 174-177. doi: 10.12032/TMR20190415116


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