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05 January 2017, Volume 2 Issue 1 Previous Issue    Next Issue
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Special Issue of Chinese Herbs
Metabonomics/metabolomics analysis technology and its application in quality control of traditional Chinese medicines
Yan Yu, Wang Shao-Hui, Wei Xu Dong, Ma Si-Bu, Liu Tong-Xiang
Traditional Medicine Research. 2017, 2 (1): 1-7.   https://doi.org/10.12032/TMR201705031
Abstract ( 567 )   HTML ( 8 )     PDF (271KB) ( 621 )  

Highlights:

This article systematically addresses metabolomics/metabonomics techniques and examples of their use in evaluation of traditional Chinese medicines. It provides a new reference for Chinese medicines and the identification and quality assessment of their products. In recent years, 1H-NMR metabonomics technology has matured. LC-MS and GC-MS metabonomics technologies have also evolved. These three analytical techniques have a good developing prospect on quality control and identification of species used in Chinese medicines, but this three techniques have their own advantages and disadvantages, Therefore, the future development should combine 1H-NMR technique with LC-MS, GC-MS techniques, and learn from each other in order to make greater contribution to the quality control of Chinese medicines.

Chinese medicines are an important part of traditional Chinese medicines, but their "safe, effective, stable and controllable" issue still remains to be solved. The rise of metabonomics in 20th century, consistent with the overall adjustment concept of multi-component, multi-level, multi-target, multi-metabolic pathways of traditional Chinese medicines, is conducive to solve basic problems in their quality control. This paper systematically describes recent application and development of 1H-NMR metabonomics techniques, LC-MS metabonomics techniques and GC-MS metabonomics techniques in the quality control of traditional Chinese medicines. It provides a new reference for Chinese medicines and the identification and quality assessment of their products.

Review
The effect of foot bath of Chinese medicine combined with acupoint injection for diabetic peripheral neuropathy: a meta analysis
Fan Yi-Hua, Zhang Qiang, Tian Rong, Jiang Jian-Hang
Traditional Medicine Research. 2017, 2 (1): 8-17.   https://doi.org/10.12032/TMR201705032
Abstract ( 598 )   HTML ( 4 )     PDF (817KB) ( 428 )  

Highlights:

Clinical trials have shown foot bath of Chinese medicine combined with acupoint injection may have significant therapeutic efficacy for the treatment of DPN. However, most of the researches were based on small samples. This study valuated the efficacy of FBCMCAI in the treatment of DPN by Meta analysis. It provided reference for clinicians seeking effective treatments for DPN.

Abstract

Objective:The aim of this systematic review was to assess the effect of foot bath of Chinese medicine combined with acupoint injection (FBCMCAI) on patients with diabetic peripheral neuropathy (DPN). Methods: Databases such as Cochrane Library, Pubmed, Web Of Science, China Biology Medicine (CBM),CNKI,VIP and WANFANG DATA were electronically searched to collect the randomized controlled trials (RCTs) (up to October 2016). According to the inclusion and exclusion criteria, literature about effects of FBCMCAI in the treatment of DPN were screened and data were extracted. Literature quality evaluation was appliced by Cochrane Reviewer Handbook 5.1.0. A random or a fixed effects model was used to analyze outcomes by RevMan 5.3 software. Subgroup analysis, sensitivity analysis, and orientation description were performed if necessary. Results: 11 randomized controlled trials with a total of 927 patients were included. Meta analysis results revealed that the efficacy of FBCMCAI for DPN was significantly superior to the control treatment (OR=5.07, 95%CI: 3.23-7.94, Z=7.08, P<0.00001). Besides, there was an increase in motor conduction velocity of peroneal nerve (SMD=1.08, 95%CI: 0.66 - 1.48,Z=5.30, P<0.00001) , motor conduction velocity of tibial nerve (SMD=1.08, 95%CI: 0.58-1.58, Z=4.22, P<0.0001) and motor conduction velocity of median nerve (SMD=0.46, 95%CI: 0.23-0.68, Z=3.96, P<0.0001) in FBCMCAI groups. For another, there was also an increase in sensory motor conduction velocity of the motor nerve (SMD=0.80,95%CI: 0.54 -1.05, Z=6.06, P<0.00001) and sensory motor conduction velocity of median nerve (SMD=0.66, 95%CI: 0.38-0.93, Z=4.73, P<0.00001) in the FBCMCAI groups. Symptoms score was significantly reduced after FBCMCAI treatment (WMD=-4.21, 95%CI[-4.95, -3.48], Z=11.25, P<0.00001). Conclusion:FBCMCAI may have significant therapeutic efficacy for the treatment of DPN. Diabetic neurologic symptoms and nerve conduction velocities can be improved under FBCMCAI treatment. In-depth research and high quality randomized controlled trials on the efficacy of FBCMCAI are necessary.

Basic Research
Investigation on the ecological suitable regionalization of Melicope ptelefolia
Wang Shao-Hui, Yan Yu, Cheng Zhe-Kang, Zeng Fan-Lin, Zhang Zong-Shen, Fan Ru-Han, Xie Cai-Xiang, Liu Tong-Xiang
Traditional Medicine Research. 2017, 2 (1): 18-26.   https://doi.org/10.12032/TMR201705033
Abstract ( 495 )   HTML ( 6 )     PDF (640KB) ( 429 )  

Highlights:

In addition, Chinese medicine pays attention to the genuineness of herbs. "Born of various drugs, all have their environment". That is to say, ecological environment in herbs’ growing has an important influence on the genuineness of medicinal herbs. The TCMGIS platform has exhibited several advantages to investigate the ecological suitable regionalization of traditional Chinese herbs. It has diversified data format, integrated with comprehensive ecological factors with various quantificational parameters. This article took the natural ecological niches of Melicope ptelefolia as basic point. The adaptable areas of Melicope ptelefolia was analyzed throughout the whole nation by using Geographic Information System for Traditional Chinese Medicine (TCMGIS). The results described in this paper provide a scientific foundation to determine the suitable areas for sustainable development and utilization of Melicope ptelefolia.

Abstract

Objective: The aim of paper is to find ecological suitable regionalization of Melicope ptelefolia planting and provide a reference for the rational planning of Good Agricultural Practices (GAP). Methods: The natural ecological niches of Melicope ptelefolia was taken as basic point. The adaptable areas of Melicope ptelefolia was analysed throughout the whole nation by using Geographic Information System for Traditional Chinese Medicine (TCMGIS). Results:Besides the original distribbution region of Guangxi, Guangdong, Hainan, Yunnan, Fujian, Jiangxi, Hunan, Guizhou, we further found that Zhejiang, Taiwan, Hong Kong, Chongqing, Sichuan are adaptable for the growth of Melicope ptelefolia. The most suitable region is Guangxi, and the followed is Guangdong. Conclusion: The ecological suitable area of Melicope ptelefolia mainly distributes in Lingnan Region, and TCMGIS is comparatively scientific and accurate to analyze suitable areas for the growth of Melicope ptelefolia. These findings have important reference value for the introduction, cultivation and scientific planning of Melicope ptelefolia.

Research on Xijiao Dihuang Decoction suppressing platelet apoptosis in immune-mediated aplastic anemia based on mitochondrial mediated pathway
Xia Le-Min, Cui Le-Le, Jiang Yi-Ling, Zheng Qin, Zhang Ai-Ping, Luo Mei-Hong
Traditional Medicine Research. 2017, 2 (1): 27-32.   https://doi.org/10.12032/TMR201705034
Abstract ( 531 )   HTML ( 5 )     PDF (285KB) ( 443 )  

Highlights:

Excessive platelet apoptosis is one of the pathogenic cause for immune-induced aplastic anemia. In the present study, we established an immune-induced aplastic anemia model and gave Xijiao Dihuang Decoction lavage daily. The results of this study indicated Xijiao Dihuang Decoction could increase platelet number and prevent its apoptosis through the mitochondrial pathway.

Abstract

The aplastic anemia mice model was established in this study. BALB/c mice shall be treated with whole body irradiation with 60 Co-γradiation (5.5Gy, 1.1Gy/min × 5 min). then within 4 h, DBA/2 mice were injected lymphocyte suspension 1 × 106 cells /mouse through caudal vein. Grouping of testing animals: Normal control mice were healthy C57BL/6 mice without AA modeling. AA control group mice were exposed to radiation and cell transfusion and had no treatment with either CSA or XDD. CSA group mice received daily lavage with 0.027g/kg (0.1ml/10g) of CSA whereas XDD group mice received daily lavage with 19.5g/kg of XDD. The experimental result indicated CSA and XDD lavage mice had significantly higher platelet count and ΔΨm than AA mice (P < 0.05). Levels of Cyt C, PS and Ca2+ were significantly lower in CSA and XDD groups compare with AA group. More specifically, compared to CSA group, XDD group also had lower level of ΔΨm and higher level of Cyt C and Ca2+ (both P < 0.05). Both CSA and XDD treatment reduced Bak and Bax levels significantly compared to AA mice. However, XDD treatment still showed higher expressions than CSA (P < 0.05). CSA and XDD treatment increased the levels of Pro-apoptotic protein expressions ( caspase-8, caspase-3, caspase-9). XDD showed less potent effect than CSA in increasing these protein expressions (all P < 0.05). Therefore, we hypothesized XDD was possible to increase platelet number and prevent its apoptosis in immune-induced AA via the mitochondrial pathway.

Anticancer effects of Xi Huang Capsule on breast cancer in vivo
Zhang Jie, Zhang Feng-Hua, Yang Sheng-Jun
Traditional Medicine Research. 2017, 2 (1): 33-40.   https://doi.org/10.12032/TMR201705035
Abstract ( 532 )   HTML ( 5 )     PDF (494KB) ( 340 )  

Highlights:

In the present study, Xi Huang Capsule (XH) was shown to be effective in reducing tumor weight, tumor volume and had a higher tumor inhibition rate in human and mice breast cancer tumor xenograft models. It also can improve the general condition of breast cancer tumor xenograft models. This study provides reference evidence for the clinical application of XH.

Abstract

Objective To investigate the anticancer effects of Xi Huang Capsule (XH) in vivo, thirty-two Nu/Nu mice inoculated with human breast cancer SKBR-3 cells and twenty-four Nu/Nu mice inoculated with murine breast cancer 4T1 cells were randomized into the control group, XH group, 5-FU group and combination of XH and 5-FU group in a 1:1:1:1 ratio. Method: The 5-FU group was injected with 5-FU at 30 mg/kg intraperitoneally every third day; XH group received doses of 0.25g/kg of XH by gastric perfusion each day; The control group was injected daily with normal saline (N.S.) intraperitoneally and the combination group was treated with 5-FU and XH on the same schedules as above. All treatments lasted for 15 days in human SKBR-3 breast cancer cells and 11 days in mice breast cancer 4T1 cells. Tumor volume, tumor weight, organ index, and change in body weight of nude mice were measured, respectively. PCNA and vimentin protein expression were examined by immunohistochemical assay. Results: In SKBR-3 cell xenograft tumor experiments, the XH group, 5-FU group and the combination group had significantly smaller tumor volumes (966.39±80.23mm3, 892.21±150.77mm3, 817.93±162.47 mm3, respectively), and lower tumor weights (0.90±0.14g, 0.84±0.32, 0.86±0.24g, respectively), as compared with the control group (all P<0.05). The combination group had the highest tumor inhibition rate (38.7%). The similar results emerged in 4T1 cell xenograft tumor. Only the combination group had the least body weight increase of SKBR-3 cells xenograft tumor (P<0.05 as compared with the control group). In SKBR-3 cell xenograft tumor experiments, the 5-FU group had a lower Liver index (43.02±5.00mg/g versus 50.95±4.59mg/g) as compared with the control group (P<0.05), whereas the combination group reversed the changes in the 5-FU group with Liver index of 49.69±4.81 mg/g (P<0.05). The combination group had a higher Spleen index (5.95±1.62 versus 4.72±0.66mg/g) as compared with the control group, and had a higher Spleen index as compared with the 5-FU group (4.54±0.79 mg/g, P<0.05). In 4T1 cell xenograft tumor experiments, the 5-FU group and the combination group had a lower Liver index (47.69±6.41, 49.87±5.96 versus 58.95±7.33), but Liver index of XH group had no significantly difference as compared with the control group. The Spleen index was the same to that in SKBR-3 cells xenograft tumor. PCNA and vimentin expression of XH group was significantly lower than that of the control group. Conclusion:The treatment of XH was equally effective in the inhibition of tumor growth, and may have potentially additional benefit in improving the general condition and immunity of the mice not only in human breast cancer cell but also in rat mammary carcinoma in vivo.

Clinical Research
Analysis on the principles of differentiation and prescription of traditional Chinese medicine in the treatment of cancerous fever
Xu Wei, Chai Ni, Cheng Yue-Lei, Yang Qiong, Zhu Hui-Rong
Traditional Medicine Research. 2017, 2 (1): 41-50.   https://doi.org/10.12032/TMR201705036
Abstract ( 660 )   HTML ( 3 )     PDF (286KB) ( 653 )  

Highlights:

Based on the published literatures of TCM treatment for cancerous fever, this study analyzed the principles of differentiation and prescription in treating cancerous fever by metrology statistics and Logistic regression analysis. It provided a reference for clinical treatment of cancerous fever.

Abstract

To investigate the principles of differentiation and prescription of traditional Chinese medicine (TCM) treatment for cancerous fever by logistic stepwise regression and literature investigation, the following databases were searched (from inception to June 30th 2016): CNKI, CSPD, CBM, PubMed, MEDLINE, EMBASE. According to the inclusion and exclusion criteria, literatures about TCM in the treatment of cancerous fever were screened. The frequency about cancerous fever of differential syndrome types, formulas and herbs were analyzed by logistic multiple regression analysis. The model about syndrome types and formula application of cancerous fever was established. The result showed formula prescriptions used most frequently were Qing-Hao-Bie-Jia decoction, Xiao-Chai-Hu decoction, Xue-Fu-Zhu-Yu decoction, Bai-Hu decoction, San-Ren decoction. The main syndrome types of cancerous fever were as follows: Toxic heat flourishing type, Yin deficiency type, Stagnation of damp-heat type, Qi-Yin deficiency type, Liver meridian depressed-heat type, Blood stasis type and Yang deficiency type. Based on regression equation of the syndrome types, the corresponding herbs of this seven syndrome types were Radix Bupleuri, Radix Paeoniae Alba and Scutellaria Baicalensis Georgi; Radix Bupleuri and Cortex Moutan; Radix Paeoniae Rubra and Radix Angelicae Sinensis; Rhizoma Pinelliae, Cortex Lycii Radicis and Radix Paeoniae Alba; Herba Artemisiae Annuae, Gypsum Fibrosum and Poria Cocos; Rhizoma Anemarrhenae, Scutellaria Baicalensis Georgi and Radix Codonopsis; Radix Bupleuri respectively. The results of Logistic regression analysis and frequency of herbs statistics can provide reference for differentiation and treatment of cancerous fever in clinical.

Safety evaluation on the clinical application of Tenghuangjiangu tablet for osteoarthritis: a hospital registration study
Clinical research collaboration group of Tenghuangjiangu tablet post-market study
Traditional Medicine Research. 2017, 2 (1): 51-57.   https://doi.org/10.12032/TMR201705037
Abstract ( 454 )   HTML ( 6 )     PDF (480KB) ( 141 )  

Highlights:

Tenghuangjiangu tablet is a Chinese medicinal formula preparation which no cutaneous anaphylaxis was found previously. In this paper, the author found two adverse reactions in combination therapy. The adverse reaction rate of the clinical application of Tenghuangjiangu tablet was 0.059%, belonged to the rare category.

Abstract:

To evaluate the treatment safety of Tenghuangjiangu tablet on osteoarthritis, 3365 osteoarthritis patients whose prescription included Tenghuangjiangu tablet from 15 hospitals were involved in the prospective and multi-center clinical trial. Tenghuangjiangu tablet dosage was decided by instruction or doctors’ experience. The course of treatment and observation was 4 weeks. The adverse drug reactions were observed in the treatment process. Results showed male and female patients were 1018(30.25%) and 2347(69.75%), respectively, and 528 patients had allergic history. The patients’ average age was 58.30 ± 8.99 years, and the average disease course was 33.29 ± 37.40 months. The average score of WOMAC scale was 95.07 ± 42.42, which indicated the light conditions. 2275 patients were treated with combined drug regimen. There were two adverse drug reactions in this research. One reaction was skin rashes with itching and the interventions were stopped original drugs and give antianaphylactic treatment. The other reaction was stomach discomfort with disgusting and the intervention was stopped the original drugs temporarily, then continued to take two drugs after 3 days and the reaction didn’t appear. The accident rate of adverse drug reaction was 0.059%. The safety of Tenghuangjiangu tablet clinical application was good, and the mechanism of adverse drug reaction should be researched in-depth.

Empirical Formula Research
Chen Shi Yang Xue An Shen Tang
Chen Nai-Li
Traditional Medicine Research. 2017, 2 (1): 58-59.   https://doi.org/10.12032/TMR201705038
Abstract ( 414 )   HTML ( 4 )     PDF (208KB) ( 363 )  
Composition

Sheng Long Chi (Apatite) 30g, Chao Suan Zao Ren (Semen Ziziphi Spinosae) 15g, Jiao Yuan Zhi (Radix Polygalae) 10g, Zhi Shou Wu (Radix Polygoni Multiflori Preparata) 10g, Gou Qi Zi (Lycium barbarum) 10g, Bai Shao (Radix Paeoniae Alba) 15g, Tian Ma (Rhizoma Gastrodiae) 10g, Sha Yuan Zi (Semen Astragali Complanati) 10g, Bai Ji Li (Fructus Tribuli) 10g, Gou Teng (Ramulus Uncariae Cum Uncis) 15g, Ju Hua (Flos Chrysanthemi ) 10g, Dan Shen (Radix Salviae Miltiorrhizae) 15g, He Huan Hua (Flos Albiziae) 10g, Chen Pi (Pericarpium Citri Reticulatae) 10g.

Indications

The vagetative nerve functional disturbance caused by dysfunction of heart and brain. Symptoms are as follows. Vertigo or dizziness, Palpitation, Insomnia, Dreaminess, Amnesia, Nocturnal emission, Inattention, Exhaustion, Irritability and dysphoria. TCM examination: Red tongue, Thin and yellow or white coating, thready, sink, rapid and small pulse.

Modified formula

Add Du Zhong (Cortex Eucommiae) for lower back pain, add ChangPu (Rhizoma Acori Tatarinowii) for dizziness, add Zhi Qiao (Fructus Aurantii) for stuffy feeling in chest, add Long Yan Rou (Arillus Longan) for palpitation, add Zhu Ye (Herba Lophatheri) for yellow urine, add Xing Ren (Semen Armeniacae Amarum) for constipation.

Contraindications

Avoid coffee and strong tea.

2019-nCoV

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