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05 April 2016, Volume 1 Issue 2 Previous Issue    Next Issue
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Orginal Article
Tradition and Modern: Public Debate between Traditional Medicine Researcher and Philosopher
Wang Ding-Ding, Wu Xiong-Zhi, Wu Xue-Jun
Traditional Medicine Research. 2016, 1 (2): 58-60.   https://doi.org/10.12032/TMR201602008
Abstract ( 320 )   HTML ( 3 )     PDF (149KB) ( 202 )  

There have been disputes about traditional and modern medicine in the past hundreds of years continually since the recent western medicine was introduced into the eastern countries. The differences between the two systems lead to the divergences in the knowledge of diseases and the ways of treatment. However, either traditional or modern medicine is a solution to treating diseases for human beings as its foothold. There are some advantages and disadvantages in both systems. What will the medical development tendency in the future be? On October 22th, 2015, the well-known philosopher Wang Dingding and the medical expert Wu Xiongzhi came across on Philosophical Forum of Traditional Medicine held by Wu Xuejun. The following is their wonderful debates on this issue.

Revaluation of Xihuang Pill on tumor treatment: from ancient literatures to modern studies
Yang Xue, Wu Xiong-Zhi
Traditional Medicine Research. 2016, 1 (2): 60-74.   https://doi.org/10.12032/TMR201602009
Abstract ( 423 )   HTML ( 4 )     PDF (544KB) ( 282 )  

Highlights:

1. In this review, we introduced the application of Xihuang Pill (XHP) on tumor therapy in ancient literatures and modern practice. 2. We also discussed the antitumor material basis and action mechanisms of Calculus Bovis, Moschus, Olibanum and Myrrha. 3. We put forward a new method to revaluate XHP on its application from ancient literatures to modern studies and from pharmacy to medicine.

Xihuang Pill (XHP), an old prescriptionsince the 18th century to treat various diseases, including breast cancer, is used widely for tumor therapy alone or in combination with chemotherapy and/or radiotherapy.XHP is composed of Niu Huang (Calculus bovis), She Xiang (Moschus),Ru Xiang (Olibanum), and Mo Yao (Myrrha).XHP was recorded to have effects on treating breast cancer, intestinal cancer, lymphomas, ovarian cancer. Modern studies indicate that XHP can inhibit tumor cells proliferation, migration, angiogenesis and regulate tumor microenvironment. In this review, we firstly introduced the application of XHP on tumor therapy in ancient literatures. Then, the antitumor studies of XHP in both clinical and basic aspects were summarized and we also discussed the antitumor material basis and mechanisms of Calculus Bovis, Moschus, Olibanum and Myrrha. In addition, with the development of time, the dosage form of XHP, source and dose of herbs and processing methods of Olibanum and Myrrha have been changed and we also evaluated the advantage and disadvantage of these changes of XHP. Taken together, XHP has various antitumor active ingredients, which is multi-target. Moreover, beneficial technology improvementhas been made in modern XHP compared to the ancient prescription. Here, we aimed to put forward a new method to revaluating XHP on its application from ancient literatures to modern studies and from pharmacy to medicine.

Epigenetic regulations of hematopoietic stem cells ageing and the regulation of traditional Chinese medicine
Yang Dao-Zheng, Luan Xin-Yuan, Wang Shu-Bin
1Traditional Medicine Research. 2016, 1 (2): 75-82.   https://doi.org/10.12032/TMR201602010
Abstract ( 323 )   HTML ( 3 )     PDF (361KB) ( 218 )  

# Equal contributors.

Highlights:

The current progress in the study of DNA methylation and histone modifications regulating HSCs ageing and the epigenetic role of TCM in the treatment of hematological malignancies were summarized.

Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Given the essential role of a stem cell to self-renew, differentiate, and proliferate, it is no wonder that they are critically important to an organism during development and to tissue self-healing and regeneration. Hematopoietic stem cells (HSCs), as one of adult stem cells, have been well characterized recently. However, the regulation mechanism of HSCs ageing remains unclear. Epigenetic alterations are now recognized as a hallmark of mammalian ageing and involved in HSCs ageing. In addition, recent studies showed that HSCs ageing is related to hematological malignancies. Therefore, epigenetic modifiers maybe novel targets for hematological malignancies therapy. Traditional Chinese medicine (TCM) has been used to treat hematological malignancies for centuries. Here, we aim to review the current progress in the study of epigenetic changes regulating HSCs ageing, particularly focusing on the epigenome and its regulators in ageing HSCs. Furthermore, we will talk about the potential of TCM in treating hematological malignancies by regulating epigenetic changes.

The regulation of method of tonifying Qi and activating blood circulation in the related gene expressions after spinal cord injury
Fan Xiao, Zhang Li
Traditional Medicine Research. 2016, 1 (2): 83-90.   https://doi.org/10.12032/TMR201602011
Abstract ( 291 )   HTML ( 3 )     PDF (291KB) ( 216 )  

Highlights:

The regulation of the genes including AQP4 gene, Bcl-2 gene, NF gene, Caspase gene, IL gene, NF-κB gene, TNF gene and HSP to treatment Spinal Cord Injury (SCI) by method of tonifying Qi and activating blood circulation was summary.

Spinal cord injury is a disease of high incidence and low cure rate without any ideal treatment. Among the complex pathological reactions, the post-injury abnormal expressions of many genes may be an important one. Method of tonifying Qi and activating blood circulation, which is one of the most important treatments of spinal cord injury in Traditional Chinese Medicine and has been used extensively in clinic, is proved to be effective in the treatment of spinal cord injury. Recently, many scholars have carried out a lot of studies in this filed and acquired notable achievements. The essay concludes mechanisms of the regulation of method of tonifying Qi and activating blood circulation in the related gene expressions after spinal cord injury to provide new thoughts and new methods for the treatment and study of spinal cord injury.

The mechanism of electro-acupuncture at Shu and Mu acupoints of lung and large intestine meridians for relieving acute gastrointestinal injury in rats with acute pancreatitis
Liu Zhen-Yan, Wu Jun, Li Si-Cheng, Su Hang, Yuan Ling, Guo Hui, Wan Mei-Hua, Tang Wen-Fu
Traditional Medicine Research. 2016, 1 (2): 91-96.   https://doi.org/10.12032/TMR201602012
Abstract ( 394 )   HTML ( 3 )     PDF (215KB) ( 205 )  

#The first three authors contribute equally to this work.

Highlights:

Based on the theory of exterior-interior relationship between the lung and the large intestine, the mechanism of electro-acupuncture at Shu and Mu acuacupoints for relieving gastrointestinal injury of AP rats was explored. We found that electro-acupuncture at shu and mu acupoints of lung and large intestine meridians (BL13, BL25, LU1, ST25) can relieve AP rats gastrointestinal injury by rebalancing inflammatory and anti-inflammatory cytokines, and making higher level of DAO, VIP, CCK.

Objectives: This study aims to explore the mechanism of alleviating gastrointestinal injury of rats with acute pancreatitis (AP) by electro-acupuncture at Shu and Mu acupoints of lung and large intestine meridians. Methods: All rats were randomly divided into 5 groups (n=40): group A [DaChengqi Decoction (DCQD), n=8], group B [Back Shu acupoints (BL13,BL25) and DCQD, n=8], group C [Front Mu acupoints (LU1,ST25) and DCQD, n=8], group D [Front Mu and Back Shu acupoints (BL13,BL25,LU1,ST25) and DCQD, n=8], and group E (the rat model of AP, n=8). The rat model of AP was established by retrograde infusion of 3% sodium taurocholate into biliary pancreatic duct. Excepting group E, all other groups were offered with DCQD by intragastric infusion within 24h after establishing models. In addition, group B, C and D received 3 times electro-acupuncture and 40 mins each time within 24 hours after establishing models, the heart blood, pancreatic tissue and intestinal tissue were took 12h after intragastric infusion to test the levels of tumor necrosis factor (TNF-α), interleukin 4 (IL-4), diamine oxidase (DAO), cholecystokinin (CCK), and vasoactive intestinal plypeptide (VIP). The pancreatic tissue and intestine tissue were taken for pathology observation.Results: Compared with group A, the level of TNF-α was lower and the level of IL-4 was higher in group B (P<0.05). Group B, C and D had higher CCK and DAO levels than group A (P<0.05). Group C had the highest CCK level of the three groups (P<0.05) and the level of DAO was better in group B, D (P<0.05). Group B, D had higher VIP level than group A and group B was the best of them (P<0.05).Conclusions: The mechanism of electro-acupuncture at Shu and Mu acuacupoints for relieving gastrointestinal injury of AP rats is associated with the rebalance between inflammatory and anti-inflammatary cytokines, and the increasing of DAO, VIP and CCK level.

Intestinal obstruction after radical surgery of cervical cancer in a patient with situs inversus
Sun Dan, Liu Yuan-Ying, Yu Tao, Zhang Zhi-Hua, Xu Sheng-Jun, Cao Yi
Traditional Medicine Research. 2016, 1 (2): 97-101.   https://doi.org/10.12032/TMR201602013
Abstract ( 327 )   HTML ( 3 )     PDF (295KB) ( 176 )  

Highlights:

1. The case of Situs Inversus (SI) patient who suffered intestinal obstruction after the radical surgery of cervical cancer is rare and complex. 2. Diagnostic and therapeutic technology were applied to the entire treatment period to assure the accuracy. 3. Further research is needed to study whether decoctions and acupuncture can help to reduce surgical complications or/and promote recovery.

Situs inversus (SI) is a rare congenital condition, which is characterized by inversion of the major visceral organs from their normal position. Although the estimated incidence of SI is low, there are still some cases have been reported recently. It is difficult for clinicians to make an appropriate diagnosis and treatment since their etiologies are not clear. With the Syndrome differentiation and treatment system, decoctions or acupuncture are often given to patients with intestinal obstruction in traditional Chinese medicine (TCM). This case study is about an SI patient who had been suffering intestinal obstruction after the radical surgery of cervical cancer.

Two Empirical Formula for Hemostasis
Li Jing, Aisin Gioro Heng-Shao
Traditional Medicine Research. 2016, 1 (2): 102-104.   https://doi.org/10.12032/TMR201602014
Abstract ( 235 )   HTML ( 3 )     PDF (205KB) ( 184 )  

Zhixue San Jin Yin Hua (Flos Lonicerae) 75g, Sheng Di (Radix Rehmanniae Recens) 75g,Bai Ji (Rhizoma Bletillae) 75g, Ma Bo (Lasiosphaera seu Calvatia) 75g, Er Cha (Catechu) 37g, Xue Jie (Sanguis Draconis)37g, Xue Yu Tan (Crinis Carbonisatus) 37g, Da Huang (Radix et Rhizoma Rhei) 30g, Chuan Lian (Rhizoma Coptidis) 30g, Huang Bai (Cortex Phellodendri) 30g, Zhi Zi (Fructus Gardeniae) 30g, Ru Xiang (Vinegar processed Olibanum) 30g, Cu Mo Yao (Vinegar processed Myrrha) 30g, Zi Ran Tong (Calcining Pyritum) 30g (Group1)

Bing Pian (Borneolum Syntheticum) 7.5g, She Xiang (Moschus) 1.5g (Group2). Grind Group1 and Group2 into powder separately, mix the powder of Group1 with Group2. Fengdao San Fang Feng (Radix Saposhnikovia) 50g, Bai Zhi (Radix Angelicae Dahuricae) 50g, Chi Shao (Radix Paeoniae Rubra) 30g, Qiang Huo (Rhizoma et Radix Notopterygii) 50g, Tian Nan Xing (Rhizoma Arisaematis) (Prepared by Ginger) 50g

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