In this review, the researchers summarized the characteristics and associated mechanisms of naringin, the pharmacologically active compound of the Chinese herb Huajuhong (Exocarpium Citri grandis, ECG) in alleviating multiple respiratory diseases, and discussed its potential application in the prevention and treatment of coronavirus disease 2019.
The Chinese herb Huajuhong is the dried epicarp of ECG, an herb that originated from Huazhou town in the Guangdong province of South China. It was first documented in an ancient book of traditional Chinese medicine, Bencao Gangmu Shiyi (Supplement to Compendium of Materia Medica), which was written in 1765 C.E. It has been used as folk herbal medicine in the treatment of respiratory diseases for hundreds of years in China. ECG was included in the Chinese Pharmacopoeia since 1977 and was a primary ingredient in many famous traditional Chinese medicine prescriptions. ECG contains flavonoids, and naringin is the primary active component.
Huajuhong (Exocarpium Citri grandis, ECG) is a traditional Chinese herbal medicine and has been used for the treatment of respiratory diseases for hundreds of years. Recently, ECG has been listed in a traditional Chinese medicine formula in the Guidelines for the Diagnosis and Treatment of Coronavirus Disease 2019 (sixth edition) in China. To date, the effect and mechanism of ECG against respiratory diseases have not been systematically reviewed. In this paper, the researchers summarized the effects of ECG and its pharmacologically active compound naringin in functioning as an antitussive and expectorant, improving lung function, alleviating acute lung injury, attenuating pulmonary fibrosis, and enhancing antiviral immune response, so as to provide a reference for its clinical application in the prevention and treatment of multiple respiratory diseases, including coronavirus disease 2019.
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