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Treating COVID-19 by traditional Chinese medicine: a charming strategy?
Yu-Liang Zhang, Wan-Ying Zhang, Xin-Zhe Zhao, Jia-Ming Xiong, Guo-Wei Zhang
1Traditional Medicine Research
Efficacy of Xuebijing injection for the treatment of coronavirus disease 2019 via network pharmacology
Yu-Liang Zhang, Qian Cui, Dou Zhang, Xin Ma, Guo-Wei Zhang
1Traditional Medicine Research
ATA Model of Health Emergency Science Popularization in China: A Pilot Study
Yi-Sen Zhao, Lin Tang, Zhe Song, Sheng-Yuan Wang, Yi-bo Wu
History & Philosophy of Medicine    2020, 2 (2): 36-40.
Abstract PDF (362KB)  
A recent novel coronavirus (COVID-19) outbreak has started since December 2019 in Wuhan, Hubei province, People’s Republic of China and has progressively expanded to various parts of China. Based on those practical problems of emergency science popularization works in the current epidemic situation, this article, from the perspective of accuracy, timeliness and acceptability of emergency science popularization, proposes that the professional science popularization knowledge should be popularized, rumor should be refuted in a timely manner, and accurate science popularization strategies should be taken for different science preference, so to provide countermeasures and guidance for problems in emergency science popularization.
Analysis on the compatibility rules and mechanism of formulae treatment for COVID-2019 based on the TCM inheritance assistance system and network pharmacology
Zi-Tong Fu, Jia-Xin Huang, Teng-Fei Bai, Guo-Wei Zhang
7Drug Combination Therapy    2020, 2 (2): 74-88.
Abstract PDF (1248KB)  
Background : On December 8, 2019, Wuhan City, Hubei Province, a new type of coronavirus disease 2019 (COVID-2019) was firstly discovered, and COVID-2019 spread rapidly in China. The number of confirmed cases in various provinces and cities rose sharply in China. In clinical treatment, Chinese medicine treatment showed significant efficacy. Since the outbreak, the National Health Commission (NHS) of China has issued seven editions of the “Pneumonitis Diagnosis and Treatment Program for COVID-2019”, at the same time, most provincial health boards and the Chinese Medicine Administration had also released information on the prevention and control scheme of COVID-2019 by Chinese medicine. The purpose of this study is to explore the compatibility rules of the main drugs in the prescription and the potential mechanism on COVID-2019 pneumonia, in order to provide reference for clinical research and new drug development of COVID-2019. Methods: This article uses the TCM inheritance assistance system and network pharmacology BATMAN-TCM online analysis system to collect and summarize the national “Pneumonitis Diagnosis and Treatment Program for COVID-2019 (trial version sixth)” and formulae for adult treatment from the TCM prevention program of 23 provinces and cities. Results: We found that the most formulae for the treatment of COVID-2019 were modified on the basis of Maxing Shigan decoction and the top 5 high-frequencyn drugs are Xingren (Armeniacae semen amarum), Mahuang (Ephedrae herba), Gancao (Glycyrrhizae radix et rhizoma), Shigao (Gypsum fibrosum), and Haungqin (Radix scutellariae). High frequency traditional Chinese medicines are mainly used for relieving the symptoms, clearing away heat, eliminating dampness, resolving phlegm, relieving cough and asthma, promoting water and dampness, and tonifying deficiency. Warm medicine and bitter medicine are the most frequently used drugs in four Qi attribute and five flavor attribute, respectively. Most of drugs are belong to lung, stomach and spleen channel. Mahuang (Ephedrae herba), Xingren (Armeniacae semen amarum), Gancao (Glycyrrhizae radix et rhizoma), Shigao (Gypsum fibrosum), Cangzhu (Atractylodis rhizama) and Huoxiang (Pogostemonis herba) are the core drugs for treating COVID-2019. The TTD disease enrichment, target and signal transduction pathways of the six drugs showed that pneumonia and asthma were most closely related to COVID-2019. And the inflammatory reaction-related pathways may be the main pathways through which these drugs function. Conclusions: The modified Maxing Shigan decoction is the main prescription for the treatment of COVID-2019. The Xingren (Armeniacae semen amarum), Gancao (Glycyrrhizae radix et rhizoma), Shigao (Gypsum fibrosum), Cangzhu (Atractylodis rhizama) and Huoxiang (Pogostemonis herba) have certain theoretical and experimental basis for the treatment of COVID-2019 through network pharmacology analysis, but further experiments are needed to verify the effects.
Mechanism prediction analysis of an epidemic prevention sachet in preventing new coronavirus pneumonia
Xin-Zhe Zhao, Zi-Qi Jin, Yao Yang, Guo-Wei Zhang
8Asian Toxicology Research    2020, 2 (2): 50-60.
Abstract PDF (937KB)  
Objective: To explore the prevention mechanism of an anti-epidemic sachet on the new coronavirus pneumonia (COVID-19) based on the network pharmacology and molecular docking method. Methods: The chemical constituents and action targets of wormwood leaves, white peony, borneol, Rhizoma atracylodis, and Herba pogostemonis in the epidemic-preventive sachet were retrieved in TCMSP database. Query the genes of targets through the Uniprot database, and then use Cytoscape 3.7.2 software to build a medicinal drugs-active ingredients-targets (genes) network for visualization. Then we used DAVID to perform gene ontology (GO) function enrichment analysis and genome encyclopedia (KEGG) pathway analysis to predict the mechanisms of action. Draw histograms and bubble charts for visualization with Excel software and Omicshare database. The crystal structure of ACE2 was searched in the RCSB PDB database, and the compounds and proteins were molecularly docked with the help of PyMOL, AutoDockTool, and Vina software. Results: Sixty-seven effective chemical components in the anti-epidemic sachet were screened and a drugs-chemical components-targets network was constructed to obtain 948 targets, and 18 core targets and 28 core target pathways were predicted. 6 compounds in Folium artemisiae argyi, 13 compounds in Radix angelicae dahuricae, 3 compounds in Rhizoma atracylodis, 4 compounds in Fructus tsaoko, 8 compounds in Herba pogostemonis, and 3 compounds in Rhizoma acori talarinowii have less binding energy with 1R42 than the ligand. Conclusion: It is predicted that the anti-epidemic sachet has prevention effects on new coronavirus pneumonia.
Clinical rational use of traditional Chinese medicine
Editor Group of Asian Toxicology Research
8Asian Toxicology Research    2020, 2 (2): 48-49.
Abstract PDF (192KB)  
Since the outbreak of COVID-19, more than 4,900 medical members of the national Chinese medicine teams stationed in Wuhan Jinyintan Hospital, Mobile Cabin Hosipital and Leishen Shan Hospital. The utilization rate of Traditional Chinese Medicine (TCM) in Hubei is 88.93% and it is 97.71% in the Chinese medicine hospital. The patients' fever, fatigue, coughing and other symptom were significantly improved. Along with the significant effects, slight adverse reaction and health concept, people pay more and more attention to the diagnostic and therapeutic approaches of TCM [1].
The potential application of the traditional Chinese herb Exocarpium Citri grandis in the prevention and treatment of COVID-19
Wei-Wei Su, Yong-Gang Wang, Pei-Bo Li, Hao Wu, Xuan Zeng, Rui Shi, Yu-Ying Zheng, Pan-Lin Li, Wei Peng
1Traditional Medicine Research    2020, 5 (3): 160-166.
Abstract HTML PDF (452KB)  


In this review, the researchers summarized the characteristics and associated mechanisms of naringin, the pharmacologically active compound of the Chinese herb Huajuhong (Exocarpium Citri grandis, ECG) in alleviating multiple respiratory diseases, and discussed its potential application in the prevention and treatment of coronavirus disease 2019.


The Chinese herb Huajuhong is the dried epicarp of ECG, an herb that originated from Huazhou town in the Guangdong province of South China. It was first documented in an ancient book of traditional Chinese medicine, Bencao Gangmu Shiyi (Supplement to Compendium of Materia Medica), which was written in 1765 C.E. It has been used as folk herbal medicine in the treatment of respiratory diseases for hundreds of years in China. ECG was included in the Chinese Pharmacopoeia since 1977 and was a primary ingredient in many famous traditional Chinese medicine prescriptions. ECG contains flavonoids, and naringin is the primary active component[9].


Huajuhong (Exocarpium Citri grandis, ECG) is a traditional Chinese herbal medicine and has been used for the treatment of respiratory diseases for hundreds of years. Recently, ECG has been listed in a traditional Chinese medicine formula in the Guidelines for the Diagnosis and Treatment of Coronavirus Disease 2019 (sixth edition) in China. To date, the effect and mechanism of ECG against respiratory diseases have not been systematically reviewed. In this paper, the researchers summarized the effects of ECG and its pharmacologically active compound naringin in functioning as an antitussive and expectorant, improving lung function, alleviating acute lung injury, attenuating pulmonary fibrosis, and enhancing antiviral immune response, so as to provide a reference for its clinical application in the prevention and treatment of multiple respiratory diseases, including coronavirus disease 2019.

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